A5049255725- Autism Spectrum Disorder Research
- Child Development and Digital Technology
- Virology and Viral Diseases
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Family and Disability Support Research
- Language Development and Disorders
- Obsessive-Compulsive Spectrum Disorders
- Behavioral and Psychological Studies
- Child Nutrition and Feeding Issues
- Neuroscience and Music Perception
- Attention Deficit Hyperactivity Disorder
- Child and Animal Learning Development
- EEG and Brain-Computer Interfaces
- Infant Development and Preterm Care
- Tactile and Sensory Interactions
- Multisensory perception and integration
- Congenital heart defects research
- Infant Health and Development
- Hearing Loss and Rehabilitation
- Assistive Technology in Communication and Mobility
- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neural Engineering
University of Geneva
2017-2025
University Hospital of Geneva
2025
Geneva College
2024
Center for Autism and Related Disorders
2022
Office Médico Pédagogique
2020
Sensory processing issues have been frequently reported in individuals with Autism Spectrum Disorders (ASD), but their relationship social and overall adaptive functioning has not extensively characterized to date. Here, we investigate how sensory atypicalities relate deficits skills, impaired cognition, general a group of preschoolers ASD. Sixty-four children ASD aged 3 6 were included this study, along 36 age-matched typically-developing (TD) peers. Parent-reported measures processing,...
Abstract Clinical research in autism has recently witnessed promising digital phenotyping results, mainly focused on single feature extraction, such as gaze, head turn name-calling or visual tracking of the moving object. The main drawback these studies is focus relatively isolated behaviors elicited by largely controlled prompts. We recognize that while diagnosis process understands indexing specific behaviors, ASD also comes with broad impairments often transcend behavioral acts. For...
Abstract Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction and repetitive behaviors. A key characteristic of ASD a decreased interest interactions, which affects individuals’ ability to engage with their environment. This study explores the neurobiological basis these deficits, focusing on pathway between Superior Colliculus (SC) Ventral Tegmental Area (VTA). Adopting translational approach, our research used Shank3 knockout mice ( −/ − ), parallel clinical...
In preschoolers with autism spectrum disorder (ASD) symptom, severity has a negative impact on the development of adaptive functioning, critical consequences quality life those children. Developmental features such as reduced social interest or presence behavioral problems can further impede daily learning experiences. The first aim this study is to confirm high symptom functioning trajectories in ASD. second objective intends explore whether and severe negatively affect developmental young...
Social impairments are a hallmark of Autism Spectrum Disorders (ASD), but empirical evidence for early brain network alterations in response to social stimuli is scant ASD. We recorded the gaze patterns and activity toddlers with ASD their typically developing peers while they explored dynamic scenes. Directed functional connectivity analyses based on electrical source imaging revealed frequency specific atypicalities theta alpha bands, manifesting as both driving connections from key nodes...
Abstract Autism spectrum disorders (ASD) are associated with disruption of large-scale brain network. Recently, we found that directed functional connectivity alterations social networks a core component atypical development at early developmental stages in ASD. Here, investigated the spatio-temporal dynamics whole-brain neuronal subsecond scale 113 toddlers and preschoolers (66 ASD) using an EEG microstate approach. We first determined predominant microstates established clustering methods....
Abstract Background Imitation skills play a crucial role in social cognitive development from early childhood. Many studies have shown deficit imitation children with autism spectrum disorders (ASD). Little is known about the of behaviors ASD. This study aims to measure trajectories preschoolers ASD and how these impact other areas development. Methods For this purpose, we assessed imitation, language, cognition 177 43 typically developing (TD) aged 2 5 years old, 126 which were followed...
Atypical deployment of social gaze is present early on in toddlers with autism spectrum disorders (ASDs). Yet, studies characterizing the developmental dynamic behind it are scarce. Here, we used a data-driven method to delineate change visual exploration interaction over childhood years autism. Longitudinal eye-tracking data were acquired as children ASD and their typically developing (TD) peers freely explored short cartoon movie. We found divergent moment-to-moment patterns compared TD...
Abstract The temporal variability of the thalamus in functional networks may provide valuable insights into pathophysiology schizophrenia. To address complexity role thalamic nuclei psychosis, we introduced micro‐co‐activation patterns (μCAPs) and employed this method on human genetic model schizophrenia 22q11.2 deletion syndrome (22q11.2DS). Participants underwent resting‐state MRI a data‐driven iterative process resulting identification six whole‐brain μCAPs with specific activity within...
Evidence-based, early intervention significantly improves developmental outcome in young children with autism. Nonetheless, there is high interindividual heterogeneity trajectories during the therapy. It established that starting as possible results better outcomes. But except for younger age at start, no clear consensus about behavioral characteristics could provide a reliable individual prediction of child's after receiving an intervention. In this study, we analyze preschoolers autism who...
The beneficial effect of early intervention is well described for children with autism spectrum disorder (ASD). Response to is, however, highly heterogeneous in affected children, and there currently only scarce information about predictors response intervention. Based on the hypothesis that impaired social orienting hinders subsequent development communication interactions ASD, we sought examine whether level modulates treatment outcome young ASD. We used eye-tracking technology measure a...
Both expressive and receptive language difficulties in autism emerge early significantly have an impact on social functioning quality of life. Despite their wide heterogeneity, autistic abilities can be stratified into three distinct profiles. Language unimpaired exhibit near-typical verbal performance, impaired show significant alterations structure, minimally display limited abilities. However, little is known about the trajectories moderators specific to each profile. Here, we used a...
Background: Recent epidemiological evidence links early-life obesity and metabolic dysregulation to adult psychosis vulnerability, though a causal relationship remains unclear. Establishing causality in highly heritable psychotic disorders requires: 1) demonstrating that factors mediate between genetic vulnerability trajectory, 2) dissecting mechanisms leading genetically vulnerable individuals, 3) clarifying downstream neurodevelopmental pathways linking symptoms. Methods: To address these...
Abstract Background Children with Autism Spectrum disorder (ASD) often exhibit communication difficulties that may stem from basic auditory temporal integration impairment but also be aggravated by an audio-visual deficit, resulting in a lack of interest face-to-face communication. This study addresses whether speech processing anomalies young autistic children (mean age 3.09-year-old) are associated alterations integration. Methods We used high-density electroencephalography (HD-EEG) and...
Selon l’une des théories les plus dominantes, l’autisme est caractérisé par une diminution de l’orientation sociale. Cette réduction l’intérêt pour le monde social apparaît dès premiers mois vie chez jeunes enfants avec un trouble du spectre autistique (TSA). Ainsi, au lieu suivre la trajectoire typique développement et d’apprendre en étant complètement immergé dans contexte social, l’enfant autiste emprunte chemin particulier. De plus, chaque enfant suit unique, car marqué grande...
Einer der führenden theoretischen Ansätze geht davon, dass Autismus durch eine verringerte Orientierung an sozialen Umwelt gekennzeichnet ist. Dieses reduzierte Interesse Welt macht sich bei Kleinkindern mit einer Autismus-Spektrum-Störung (ASS) bereits in den ersten Lebensmonaten bemerkbar. Das Kind also nicht typischen Entwicklungsweg und lernt unter vollständiger Einbeziehung des Kontexts. Es zeigt stattdessen andersartige Entwicklungstrajektorie. Diese Entwicklung verläuft zudem jedem...
Autism early intervention meta-analyses have provided initial answers to questions such as ' what types of interventions work and for outcomes '? However, we also want know whom is most effective for? Mega-analysis can offer up complementary insights regarding the works ', while offering unique into question. Here conduct a mega-analysis with linear mixed effect modeling on AEIR consortium datasets totaling n=645 children spanning several countries (e.g., USA, Switzerland, Italy, Israel,...
The brain's ability to regulate blood flow is fundamental both its function and development. In the context of neurodevelopmental disorders such as schizophrenia, understanding complex interactions between cerebrovascular health brain crucial for unraveling pathophysiology psychosis. This study investigates developmental trajectory reactivity (CVR) in 22q11 deletion syndrome (22q11.2DS) compared healthy controls, association with psychosis susceptibility. Using a longitudinal data-set...
Background: Atypical neural processing of social visual information contributes to impaired cognition in autism spectrum disorder. However, evidence for early developmental alterations contingencies is scarce. Most studies the literature have been conducted older children and adults. Here, we aimed investigate with disorder compared age-matched typically developing peers. Methods: We used a combination 129-channel electroencephalography high-resolution eye-tracking study differences dynamic...
Atypical prosody in speech production is a core feature of Autism Spectrum Disorder (ASD) that can impact everyday life communication. Because the ability to modulate develops around age acquisition, it might be affected by ASD symptoms and developmental delays emerge at same period. Here, we investigated existence prosodic signature level symptom severity sample 74 autistic preschoolers. We first developed an original diarization pipeline extract preschoolers' vocalizations from recordings...
Communication difficulties are one of the core criteria in diagnosing autism spectrum disorder (ASD), and often characterized by speech reception difficulties, whose biological underpinnings not yet identified. This deficit could denote atypical neuronal ensemble activity, as reflected neural oscillations. Atypical cross-frequency oscillation coupling, particular, disrupt joint tracking prediction dynamic acoustic stimuli, a dual process that is essential for comprehension. Whether such...
Most studies in children with autism spectrum disorder (ASD) support a decrement imitation performance. Factors related to visual attention and motor execution have been proposed explain this phenomenon ASD. However, investigated various methods, leading inconsistent findings. Here, we examine performance execution. We focused on the of meaningful meaningless gestures, consistently reported as more affected than actions objects The eye-tracking task consisted video an actor demonstrating...
Nowadays, 1 in 36 children is diagnosed with autism spectrum disorder (ASD) according to the Centers for Disease Control and Prevention (CDC) [52], which makes this condition one of most prevalent neurodevelopmental disorders. For on who face substantial developmental delays, trajectory their cognitive growth can be markedly improved by interventions if identified early. Therefore, there a critical need more scalable screening diagnostic tools, as well improve phenotyping refine estimates...