A5110850258- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Heart Rate Variability and Autonomic Control
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Advanced Neuroimaging Techniques and Applications
- Mental Health and Psychiatry
- Complex Systems and Time Series Analysis
- Memory and Neural Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Dermatology and Skin Diseases
- Attention Deficit Hyperactivity Disorder
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Mental Health Treatment and Access
- Digital Mental Health Interventions
- Body Image and Dysmorphia Studies
- Vestibular and auditory disorders
- Technology and Human Factors in Education and Health
- Neuroscience of respiration and sleep
- Obsessive-Compulsive Spectrum Disorders
- Cognitive and psychological constructs research
- Genetic Associations and Epidemiology
University Medical Center Utrecht
2012-2024
Utrecht University
2020-2022
Hersenstichting
2018-2022
Heidelberg University
2021
University Hospital Heidelberg
2021
Wellcome Centre for Human Neuroimaging
2020
King's College London
2020
Eli Lilly (Netherlands)
2012
ABSTRACT BACKGROUND Predicting outcomes in schizophrenia spectrum disorders is challenging due to the variability of individual trajectories. While machine learning (ML) shows promise outcome prediction, has not yet been integrated into clinical practice. Understanding how ML models (MLMs) can complement psychiatrists’ predictions and bridge gap between MLM capabilities practical use key. OBJECTIVE This study aims compare performance psychiatrists MLMs predicting short-term symptomatic...
Background COVID-19 has seriously affected physical and mental health world-wide,both due to spreading of the virus socially restrictive measures most governments have enforced. Increased anxiety, stress depressive symptoms been widely reported in general population. The current study investigated effects COVID Netherlands on stress, anxiety loneliness patients with a pre-existing psychiatric disorder. Methods 189 disorder treated at University Medical Center Utrecht (UMCU) provided consent...
Negative symptoms are one of the most incapacitating features Schizophrenia but their pathophysiology remains unclear. They have been linked to alterations in grey matter several brain regions, findings inconsistent. This may reflect investigation relatively small patient samples, and confounding effects chronic illness exposure antipsychotic medication. We sought address these issues by investigating concurrently volumes (GMV) cortical thickness (CTh) a large sample antipsychotic-naïve or...
Background Social functioning is often impaired in schizophrenia (SZ) and Alzheimer’s disease (AD). However, commonalities differences social dysfunction among these patient groups remain elusive. Materials methods Using data from the PRISM study, behavioral (all subscales total score of Functioning Scale) affective (perceived disability loneliness) indicators were measured patients with SZ ( N = 56), probable AD 50) age-matched healthy controls (HC, 29 28). We examined to what extent...
Social dysfunction is commonly present in neuropsychiatric disorders of schizophrenia (SZ) and Alzheimer's disease (AD). Theory Mind (ToM) deficits have been linked to social disease-specific studies. Nevertheless, it remains unclear how ToM related functioning across these disorders, which factors contribute this relationship. We investigated transdiagnostic associations between among SZ/AD patients healthy controls, explored what extent relate information processing speed or facial emotion...
An insight into preferences, satisfaction and treatment goals of patients is important for reaching alliance may increase the success initiated treatment. Participants from Netherlands, with at least one psychotic episode, were asked to fill in an online questionnaire. ranked their priorities content, stated whether they satisfied on these items a list goals. 462 respondents preferences regarding content (mean age: 40.3 years; mean duration illness: 13.5 years). Items most important: "prompt...
Individuals with psychoses have brain alterations, particularly in frontal and temporal cortices, that may be prominent, already at illness onset, those more likely to poorer symptom remission following treatment the first antipsychotic. The identification of strong neuroanatomical markers could thus facilitate stratification individualized patients schizophrenia. We used magnetic resonance imaging baseline examine regional network correlates subsequent symptomatic 167 medication-naïve or...
The symptom severity of a substantial group schizophrenia patients (30-40%) does not improve through pharmacotherapy with antipsychotic medication, indicating clear need for new treatment options to outcome. Meta-analyses, genetic studies, randomized controlled trials, and post-mortem studies suggest that immune dysregulation plays role in the pathophysiology schizophrenia. Some anti-inflammatory drugs have shown beneficial effects on patients. Corticosteroids are effective various chronic...
Several multivariate prognostic models have been published to predict outcomes in patients with first episode psychosis (FEP), but it remains unclear whether those predictions generalize independent populations. Using a subset of demographic and clinical baseline predictors, we aimed develop externally validate different predicting functional outcome after FEP the context schizophrenia-spectrum disorder (FES), based on previously cross-validation machine learning pipeline. A crossover...
Persistent negative symptoms are associated with worse outcome in both first-episode and chronic subjects schizophrenia. The identification of these recent-onset is still controversial as retrospective data often unavailable. prospective assessment persistence might represent a valid alternative but the length to be established. present study investigated prevalence moderate severity, unconfounded by depression extrapyramidal at baseline large cohort patients early stage...