A5062882785- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neurological disorders and treatments
- Diet and metabolism studies
- Treatment of Major Depression
- Cannabis and Cannabinoid Research
- Bipolar Disorder and Treatment
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- Mental Health Research Topics
- Epilepsy research and treatment
- Mental Health and Psychiatry
- Medical Imaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Electroconvulsive Therapy Studies
- Advanced NMR Techniques and Applications
- Neural and Behavioral Psychology Studies
- Epigenetics and DNA Methylation
- Complement system in diseases
King's College London
2016-2025
Wellcome Centre for Human Neuroimaging
2024
South London and Maudsley NHS Foundation Trust
2020-2024
National Institute for Health Research
2020-2023
Campbell Collaboration
2022
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2020
Kings Health Partners
2012-2020
Institute of Physics
2020
King's College School
2018
University of Roehampton
2015
Alterations in glutamatergic neurotransmission may be fundamental to the pathophysiology of schizophrenia, and system is a target for novel therapeutic interventions disorder.To investigate nature brain glutamate alterations schizophrenia by conducting meta-analysis proton magnetic resonance (MRS) spectroscopy studies.The MEDLINE database was searched studies published from January 1, 1980, April 2015. Search terms included spectroscopy, psychosis, clinical or genetic high risk,...
Objective: While there is robust evidence of elevated dopamine synthesis capacity once a psychotic disorder has developed, little known about whether it altered prior to the first episode frank illness. The authors addressed this issue by measuring in individuals at ultra-high risk psychosis and then following them determine their clinical outcome. Method: This prospective study included 30 patients who met standard criteria for being 29 healthy volunteers. Participants were scanned using...
Resistance to antipsychotic treatment is a significant clinical problem in patients with schizophrenia approximately 1 3 showing limited or no response repeated treatments medication. The neurobiological basis for resistance unknown but recent evidence implicates glutamatergic function the anterior cingulate cortex. We examined glutamate levels of chronically ill treatment-resistant directly compared treatment-responsive patients.We acquired proton magnetic resonance spectroscopy (1H-MRS) at...
<h3>Importance</h3> Previous in vitro and postmortem research suggests that inflammation may lead to structural brain changes via activation of microglia and/or astrocytic dysfunction a range neuropsychiatric disorders. <h3>Objective</h3> To investigate the relationship between structures vivo explore transcriptome-driven functional basis with relevance mental illness. <h3>Design, Setting, Participants</h3> This study used multistage linked analyses, including mendelian randomization (MR),...
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal D2/D3 receptor availability has been reported in drug addiction, may constitute premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess PG, its association trait impulsivity. Males PG (n = 9) male healthy controls underwent [11C]-raclopride positron emission tomography imaging completed UPPS-P scale. There...
Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent finding schizophrenia, and include large effect size elevation synthesis capacity. However, it is not known if the dopaminergic dysfunction limited to terminals neurons, or also evident neuron cell bodies, which mostly originate substantia nigra. The aim our studies was therefore determine whether capacity altered nigra people with how this relates symptoms. In post-mortem study, semi-quantitative...
Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated responders unaltered non-responders. We therefore aimed test a prospective cohort, nested case-control comparison. 40 volunteers (26 patients first-episode psychosis 14 controls)...
Background: People at ultra high risk (UHR) of psychosis have an elevated developing a psychotic disorder, but it is difficult to predict which individuals will make transition frank illness. We investigated whether functional magnetic resonance imaging (fMRI) in conjunction with phonological fluency task presentation could distinguish subjects who subsequently developed from those did not. Methods: Sixty-five (41 UHR and 24 healthy controls) were assessed clinical using fMRI, verbal task....
Objective: Animal models suggest that the development of psychosis involves hyperactivity in hippocampus drives increased activity midbrain and basal ganglia. The authors examined this hypothesis by measuring resting perfusion hippocampus, ganglia, people at high risk psychosis. Method: Pseudo-continuous arterial spin labeling imaging was used to measure regional cerebral blood flow (rCBF) 52 individuals ultra-high for 27 healthy volunteers. severity psychotic symptoms assessed using...
The pathophysiology of psychosis is incompletely understood. Disruption in cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity a proposed model for psychosis, but has not been tested vivo. We therefore aimed to test the relationship between glutamate concentrations and capacity, psychotic symptoms.In this cross-sectional multimodal imaging study, 28 individuals with first-episode healthy controls underwent 18F-DOPA PET (measuring capacity), proton magnetic...
Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective study was to examine relationship between childhood function early Secondary objectives were compare exposure young people at ultra high (UHR) healthy volunteers. Sixty-seven adults, comprising 47 individuals UHR for 20 volunteers recruited from same geographic area matched age, gender...