A5051651052- Schizophrenia research and treatment
- Treatment of Major Depression
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Electroconvulsive Therapy Studies
- Mental Health Treatment and Access
- Mental Health Research Topics
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Long-Term Effects of COVID-19
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Toxicity Studies
- Medical Imaging Techniques and Applications
- Mental Health and Psychiatry
- Pluripotent Stem Cells Research
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Congenital heart defects research
- Paranormal Experiences and Beliefs
- Heart Rate Variability and Autonomic Control
Medical University of Vienna
2016-2025
Douglas College
2024
McGill University
2024
University of Campania "Luigi Vanvitelli"
2019
Abstract Schizophrenia is characterized by increased behavioral and neurochemical responses to dopamine-releasing drugs. This prompted the hypothesis of psychosis as a state “endogenous” sensitization dopamine system although exact basis dopaminergic disturbances possible role prefrontal cortical regulation have remained uncertain. To show that patients with first-episode release more upon amphetamine-stimulation than healthy volunteers, reveal for first time prospective induced repeated...
Sex-related effects on the evolution and phenotype of major depressive disorder (MDD) were reported previously.This European multicenter cross-sectional study compared sociodemographic, clinical, treatment patterns between males females in a real-world sample 1410 in- outpatients with current MDD.Male MDD patients (33.1%) rather inpatients, suffered from moderate to high suicidality levels, received noradrenergic specific serotonergic antidepressants (ADs) as first-line AD treatment,...
DiGeorge syndrome or 22q11.2 deletion is one of the most common genetic microdeletion syndromes in humans. In addition to physical manifestations, associated with a high prevalence psychiatric disorders, such as intellectual disability, schizophrenia and attention-deficit/hyperactivity disorder. Usually, diagnosis made early childhood. This article reports on late patient panic disorder comorbid major depression at age 51. Since testing was not available before 1990s, there might be many...
Background Cardio-pulmonary-resuscitation (CPR) training starting at the age of 12 years is recommended internationally. Training younger children not because young lack physical ability to perform adequate CPR and discouragement later apprehended. The aim this study was answer following questions: Are discouraged after training? Is caused by their in chest compressions on a standard manikin would use manikins with reduced resistance affect motivation or performance? Methods We investigated...
The clinical phenotype of the so-called late-onset depression (LOD) affecting up to 30% older adults and yielding heterogeneous manifestations concerning symptoms, severity course has not been fully elucidated yet. This European, cross-sectional, non-interventional, naturalistic multicenter study systematically investigated socio-demographic correlates early-onset (EOD) LOD (age onset ≥ 50 years) in 1410 adult in- outpatients both sexes receiving adequate psychopharmacotherapy. In a total...
The dopamine theory of schizophrenia suggests that antipsychotics alleviate symptoms by blocking D2/3 receptors, yet a significant subset patients does not respond adequately to treatment. To investigate potential predictors, we evaluated d-amphetamine-induced release and 1-year clinical outcomes in 21 antipsychotic-naive with first-episode schizophrenia.
Open access post-mortem transcriptome atlases such as the Allen Human Brain Atlas (AHBA) can inform us about mRNA expression of numerous proteins interest across whole brain, while in vivo protein binding human brain be quantified by means neuroreceptor positron emission tomography (PET). By combining both modalities, association between regional gene and receptor distribution living approximated. Here, we compare characteristics D2 D3 dopamine applying D2/3 agonist radioligand...
Evidence of elevated peripheral Neurofilament light-chain (NfL) as a biomarker neuronal injury can be utilized to reveal nonspecific axonal damage, which could reflect altered neuroimmune function. To date, only few studies have investigated NfL fluid in schizophrenia primarily, though none its putative prodrome (Clinical High-Risk, CHR) or untreated first-episode psychosis (FEP). Further, it is unknown whether associated with 18 kDa translocator protein (TSPO), validated marker. In this...
An elemental function of brain dopamine is to coordinate cognitive and motor resources for successful exploitation environmental energy sources. Dopamine transmission, goal-directed behavior, glucose homeostasis are altered in schizophrenia patients prior after initiation pharmacological treatment. Thus, we investigated the relationship between blood levels signaling drug-naïve with first-episode psychosis. We quantified binding D2/3 receptor agonist radioligand (+)-[11C]-PHNO 15...
Serotonin-norepinephrine reuptake inhibitors (SNRIs) are among the most frequently prescribed antidepressants (ADs) for major depressive disorder (MDD), with an increasing trend in last decade. Given relative dearth of information regarding rationales their preferred use as first-line ADs broad clinical routine, present study systematically investigated real-world characteristics MDD patients either SNRIs or other AD substances across different countries and treatment settings.In secondary...
The second-generation anticonvulsant lamotrigine is widely used in the psychiatric field as a mood stabilizer or antidepressant augmentation therapy. Although particularly older anticonvulsants are known for their potential to cause hypersensitivity syndromes, newer antiepileptic drugs do hold certain risk well. Presenting case of 32-year-old male inpatient African ethnicity suffering from primary severe depressive episode course recurrent major disorder, we report occurrence rapid-onset...
Valproic acid (VPA) has been increasingly shown to trigger hyperammonemic encephalopathies in patients suffering from urea cycle defects and those receiving polypharmacy. We report on two cases of psychiatric inpatients with regular VPA intake who showed severe cognitive impairment due non-cirrhotic hyperammonaemia without overdosing. In the first case, OTC deficiency appeared be underlying cause a comatose state middle-aged bipolar female patient. Besides hyperammonemia, we identified...
Several multivariate prognostic models have been published to predict outcomes in patients with first episode psychosis (FEP), but it remains unclear whether those predictions generalize independent populations. Using a subset of demographic and clinical baseline predictors, we aimed develop externally validate different predicting functional outcome after FEP the context schizophrenia-spectrum disorder (FES), based on previously cross-validation machine learning pipeline. A crossover...
Background Stress and traumatic experiences are well-established risk factors for psychiatric disorders. Stressful events can induce symptoms of anxiety depression may lead to overt psychosis, especially when there is an innate biological vulnerability. This study explores the role stress-regulating endocannabinoid system, specifically activity enzyme fatty acid amid hydrolase (FAAH), a key regulatory endocannabinoids, in association with stress by analysing data from healthy individuals...