A5081953842- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Polysaccharides and Plant Cell Walls
- Galectins and Cancer Biology
- Advanced Cellulose Research Studies
- Cancer, Lipids, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Biofuel production and bioconversion
- Monoclonal and Polyclonal Antibodies Research
- Schizophrenia research and treatment
- Prostate Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Metal complexes synthesis and properties
- Diet and metabolism studies
- Sarcoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Prenatal Substance Exposure Effects
- Crystallization and Solubility Studies
Pennsylvania State University
2022-2024
Medical University of Vienna
2015-2021
University of Vienna
2016-2018
Primary staging of prostate cancer relies on modalities, which are limited. We evaluate simultaneous [68Ga]Ga-PSMA-11 PET (PSMA-PET)/MRI as a new diagnostic method for primary tumor-node-metastasis compared with histology and its impact therapeutic decisions.We investigated 122 patients PSMA-PET/MRI prior to planned radical prostatectomy (RP). endpoint was the accuracy in tumor staging-relevant histology. In addition, multidisciplinary team reassessed initial approach management.PSMA-PET/MRI...
The first aim of this study was to evaluate 68Ga-PSMAHBED-CC conjugate 11 positron emission tomography (PSMA PET) parameters for assessment response 177Lu-PSMA-617 radioligand therapy (RLT) in patients with metastatic castration-resistant prostate cancer (mCRPC). second investigate factors associated overall survival (OS). We retrospectively assessed mean standardized uptake values (SUVmean) and total tumor volumes (TTV) on PSMA PET 38 55 mCRPC before after RLT. PSA testing PET/CT(MRI)...
To evaluate the diagnostic performance of [68Ga]Ga-PSMAHBED-CC conjugate 11 positron emission tomography (PSMA-PET) in early detection metastases patients with biochemical recurrence (BCR) after radical prostatectomy (RP) for clinically non-metastatic prostate cancer, to compare it CT/MRI alone and assess its impact on further therapeutic decisions. We retrospectively assessed 117 consecutive hormone-naïve BCR who had 68Ga-PSMA PET/CT (n = 46) or PET/MRI 71) between May 2014 January 2017....
Abstract Background To assess which parameters of [ 68 Ga]Ga‐PSMA‐11 positron emission tomography (PSMA‐PET) predict response to systemic therapies in metastatic (m) castration‐resistant prostate cancer (CRPC). In addition, investigate these factors are associated with overall survival (OS). Methods We retrospectively assessed the following PSMA‐PET 43 patients before and after for mCRPC: PSMA total tumor volume (TTV), mean standardized uptake value (SUVmean), SUVmax, SUVpeak....
MALT lymphomas express the chemokine receptor CXCR4 on a regular basis, and [68Ga]Ga-Pentixafor-PET has been shown to quantify expression non-invasively. We, therefore, aimed evaluate [68Ga]Ga-Pentixafor-PET/MRI for non-invasive assessment of lymphomas.We included 36 lymphoma patients, who had not undergone previous systemic or radiation therapy, in our prospective, IRB-approved, proof-of-concept study. Involved anatomic regions were orbit (n=14), stomach (n=10), lungs (n=5), other sites...
Objectives This prospective proof-of-principle study aimed to determine whether [ 68 Ga]Ga-Pentixafor uptake, which reflects CXCR4 expression, is higher in the bone marrow of chronic lymphocytic leukemia (CLL) than other oncological diseases without infiltration and can therefore be used for CLL imaging. Materials Methods Thirteen patients 20 controls (10 with pancreatic adenocarcinoma 10 mucosa-associated lymphoid tissue lymphoma) histologically proven cancer underwent positron emission...
One of the most promising classes iron chelators are α-N-heterocyclic thiosemicarbazones with Triapine as prominent representative. In several clinical trials showed anticancer activity against hematological diseases, however, studies on solid tumors failed due to widely unknown reasons. Some years ago, it was recognized that "terminal dimethylation" can lead a more than 100-fold increased activity, probably interactions cellular copper depots. To better understand structural requirements...
Lignification waterproofs and strengthens the secondary plant cell wall, while increasing energy cost associated with releasing sugars for biofuel production. The physical association between lignin carbohydrate scaffold that accommodates polymerization, as well temporally distinct roles of different units partners during lignification, remain largely unclear. Here we map lignin-carbohydrate interactions by solid-state NMR in 13C-labeled Arabidopsis inflorescence stems walls are formed....
99mTc-PHC-102 is a 99mTc-labeled derivative of acetazolamide, high-affinity small organic ligand carbonic anhydrase IX (CAIX). has previously shown favorable in vivo biodistribution properties mouse models CAIX-positive clear cell renal carcinoma (ccRCC) and colorectal cancer. In this study, we aimed to explore the targeting performance SPECT patients with while also assessing safety tolerability radiotracer. Methods: We studied 5 localized or metastatic ccRCC microdosing regimen, after...
For PET imaging of mantle cell lymphoma (MCL), [18F]FDG (2-deoxy-2-[18F]fluoro-D-glucose) is the currently recommended radiotracer, although uptake variable and bone marrow evaluation limited. In this prospective study, we evaluated novel CXCR4 (G-protein-coupled C-X-C chemokine receptor type 4) tracer [68Ga]Pentixafor in MCL patients, compared it to [18F]FDG. Methods: patients underwent [68Ga]Pentixafor-PET/MRI, and, if required for routine purposes, also [18F]FDG-PET/MRI, before treatment....
To assess the accuracy of [68Ga]-PSMA-11 PET/CT or PET/MRI (PSMA-11 PET/CT(MRI)) for lymph node (LN) staging using salvage LN dissection (SLND) in patients with biochemical recurrence (BCR) after radical prostatectomy (RP). In a prospective study, 65 consecutive who developed BCR RP underwent SLND PSMA-11 PET/CT(MRI) between 2014 and 2018. Extended up to inferior mesenteric artery was performed all patients. Regional template-based correlations presence metastases on histopathology...
Abstract Schizophrenia is characterized by increased behavioral and neurochemical responses to dopamine-releasing drugs. This prompted the hypothesis of psychosis as a state “endogenous” sensitization dopamine system although exact basis dopaminergic disturbances possible role prefrontal cortical regulation have remained uncertain. To show that patients with first-episode release more upon amphetamine-stimulation than healthy volunteers, reveal for first time prospective induced repeated...
Degrading cellulose is a key step in the processing of lignocellulosic biomass into bioethanol. Cellobiose, disaccharide product degradation, has been shown to inhibit cellulase activity, but mechanisms underlying inhibition are not clear. We combined single-molecule imaging and biochemical investigations with goal revealing mechanism by which cellobiose inhibits activity Trichoderma reesei Cel7A, well-characterized exo-cellulase. find that slows processive velocity Cel7A shortens distance...
Abstract Xylem tracheary elements (TEs) synthesize patterned secondary cell walls (SCWs) to reinforce against the negative pressure of water transport. VASCULAR-RELATED NAC-DOMAIN 7 (VND7) induces differentiation, accompanied by cellulose, xylan, and lignin deposition into banded domains. To investigate effect polymer biosynthesis mutations on SCW patterning, we developed a method induce element transdifferentiation isolated protoplasts, transient transformation with VND7. Our data showed...
Abstract Bruton tyrosine kinase inhibitor ibrutinib is effective in treating chronic lymphocytic leukemia (CLL). However, after treatment initiation, patients frequently experience an increase of CLL blood cell count. This phenomenon clinical practice thought to reflect a “compartment shift” cells from lymph nodes the peripheral blood, but actual shifting has not yet been demonstrated. Using [68Ga]Pentixafor-PET/MRI for vivo CXCR4 visualization, we here provide images topical changes upon...
HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this its prescribed limit 200 μg per recommended application volume the final formulation. Currently, TLC test according to European Pharmacopoeia (Ph. Eur.) has be performed quantification, but analysis suffers from low reliability and reproducibility based on subjective, semi-quantitative visual evaluation. In study, method Ph. Eur. two literature-known HPLC assays quantification were...
Positron emission tomography (PET) as a tool for molecular imaging of cancer has gained huge interest in the last few years. Gallium-68 is popular PET nuclide due to its favorable characteristics, like advantageous half-life (68 min) and independency cyclotron on-site production. Accordingly, several 68Ga-complexes via have been made available during In this work, 68Ga-labeled compounds were synthesized applying commercially microfluidic device first time. Therefore, proof principle study...
An elemental function of brain dopamine is to coordinate cognitive and motor resources for successful exploitation environmental energy sources. Dopamine transmission, goal-directed behavior, glucose homeostasis are altered in schizophrenia patients prior after initiation pharmacological treatment. Thus, we investigated the relationship between blood levels signaling drug-naïve with first-episode psychosis. We quantified binding D2/3 receptor agonist radioligand (+)-[11C]-PHNO 15...
OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets V. Radchenko, J.W. Engle, C. Roy, J. Griswold, M.F. Nortier, E.R. Birnbaum, M. Brugh, S. Mirzadeh, K. D. John, M.E. Fassbender OP04 Comparison [68Ga]FSC(succ-RGD)3 and [68Ga]NODAGA-RGD for PET imaging αvβ3 integrin expression Chuangyan Zhai, Gerben Franssen, Milos Petrik, Peter Laverman, Clemens Decristoforo OP05 A new NPY-Y1R targeting peptide breast cancer Ait-Mohand Samia, Dumulon-Perreault...