A5041785050- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Radioactive element chemistry and processing
- Nuclear reactor physics and engineering
- Chemical Synthesis and Characterization
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Nuclear physics research studies
- Lanthanide and Transition Metal Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Medical Imaging and Pathology Studies
- Particle accelerators and beam dynamics
- Nuclear Materials and Properties
- Boron Compounds in Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Mesoporous Materials and Catalysis
- Radiation Detection and Scintillator Technologies
- Zeolite Catalysis and Synthesis
- Muon and positron interactions and applications
- Graphite, nuclear technology, radiation studies
- Metal-Catalyzed Oxygenation Mechanisms
- Crystallography and molecular interactions
- Phase Equilibria and Thermodynamics
- Neutrino Physics Research
Los Alamos National Laboratory
2012-2021
Los Alamos Medical Center
2005-2018
International Isotopes (United States)
2012
Scripps Research Institute
2002
California Institute of Technology
1995-1997
Abstract Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators medicinal applications has been hindered by limited understanding of actinium chemistry. This knowledge gap primarily associated with handling actinium, as it highly radioactive and short supply. Hence, Ac III reactivity often inferred from the lanthanides minor actinides (that is, Am, Cm), success. Here we overcome these challenges characterize HCl solutions using X-ray...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures, Electronic Properties, and Oxidation-Reduction Reactivity of Halogenated Iron PorphyrinsMark W. Grinstaff, Michael G. Hill, Eva R. Birnbaum, William P. Schaefer, Jay A. Labinger, Harry B. GrayCite this: Inorg. Chem. 1995, 34, 19, 4896–4902Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September...
Metal aquo ions occupy central roles in all equilibria that define metal complexation natural environments. These complexes are used to establish thermodynamic metrics (i.e., stability constants) for predicting binding, which essential defining critical parameters associated with aqueous speciation, chelation, vivo transport, and so on. As such, establishing the fundamental chemistry of actinium(III) ion (Ac-aquo ion, Ac(H2O)x3+) is current efforts develop 225Ac [t1/2 = 10.0(1) d] as a...
A major chemical challenge facing implementation of 225Ac in targeted alpha therapy—an emerging technology that has potential for treatment disease—is identifying an chelator is compatible with vivo applications. It unclear how to tailor a Ac binding because coordination chemistry poorly defined. Most inferred from radiochemical experiments carried out on microscopic scales. Of the few compounds have been characterized spectroscopically, success only reported simple inorganic ligands. Toward...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT19F NMR Spectra and Structures of Halogenated PorphyrinsEva R. Birnbaum, Julia A. Hodge, Mark W. Grinstaff, William P. Schaefer, Lawrence Henling, Jay Labinger, John E. Bercaw, Harry B. GrayCite this: Inorg. Chem. 1995, 34, 14, 3625–3632Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ic00118a010https://doi.org/10.1021/ic00118a010research-articleACS...
A new method has been developed for the isolation of 223,224,225Ra, in high yield and purity, from a proton irradiated 232Th matrix. Herein we report an all-aqueous process using multiple solid-supported adsorption steps including citrate chelation to remove >99.9% barium contaminants by activity final radium product. procedure involving use three columns succession was developed, separation 223,224,225Ra thorium matrix obtained with overall recovery 91 ± 3%, average radiochemical purity...
Nuclear formation cross sections are reported for 65 nuclides produced from 800-MeV proton irradiation of thorium foils. These data useful as benchmarks computational predictions in the ongoing process theoretical code development and also design spallation-based radioisotope production currently being considered multiple radiotherapeutic pharmaceutical agents. Measured compared with three mcnp6 event generators used to evaluate potential productions radioisotopes interest medical...
Abstract Accelerator production of 225 Ac addresses the global supply deficiency currently inhibiting clinical trials from establishing Ac's therapeutic utility, provided that accelerator product is sufficient radionuclidic purity for patient use. Two proton activation experiments utilizing stacked foil technique between 40 and 200 MeV were employed to study likely co-formation radionuclides expected be especially challenging separate Ac. Foils assayed by nondestructive γ -spectroscopy α...
Abstract Rhenium-186g ( T 1/2 = 89.2 h) is a β − emitter suitable for therapeutic applications. Current production methods rely on reactor via 185 Re( n , γ ) which results in low specific activities, thereby limiting its use. Production by p d activation of enriched 186 W 186g Re product with higher activity, allowing it to be used targeted therapy limited receptors. A test target consisting pressed, sintered nat WO 3 was proton irradiated at Los Alamos (LANL-IPF) evaluate yield and...