A5016959035- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Anesthesia and Neurotoxicity Research
- Chemical Reactions and Isotopes
- Neurological disorders and treatments
- Health, Environment, Cognitive Aging
- Obsessive-Compulsive Spectrum Disorders
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2025
Seoul National University
2016
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2016
Innsbruck Medical University
2015
Universität Innsbruck
2015
Background:Schizophrenia has been associated with disturbances of thalamic functioning. In light recent evidence suggesting a significant impact the glutamatergic system on key symptoms schizophrenia, we assessed whether modulation via blockage N-methyl-d-aspartate (NMDA)-receptor might lead to changes functional connectivity.
Article Abstract Objective: The study objective was to generate a prediction model for treatment-resistant depression (TRD) using machine learning featuring large set of 47 clinical and sociodemographic predictors treatment outcome. Method: 552 Patients diagnosed with major depressive disorder (MDD) according DSM-IV criteria were enrolled between 2011 2016. TRD defined as failure reach response antidepressant treatment, characterized by Montgomery-Asberg Depression Rating Scale (MADRS) score...
Background Electroconvulsive therapy (ECT) is the treatment of choice for severe mental illness including treatment-resistant depression (TRD). Increases in volume hippocampus and amygdala following ECT have consistently been reported. Aims To investigate neuroplastic changes after specific hippocampal subfields nuclei using high-resolution structural magnetic resonance imaging (MRI) (trial registration: clinicaltrials.gov – NCT02379767). Method MRI scans were carried out 14 patients (11...
The ability to solve cognitive tasks depends upon adaptive changes in the organization of whole-brain functional networks. However, link between task-induced network reconfigurations and their underlying energy demands is poorly understood. We address this by multimodal analyses integrating molecular neuroimaging acquired concurrently during a complex task. Task engagement elicited marked increase association glucose consumption brain reorganization. This convergence metabolic neural...
The investigation of cerebral metabolic rate glucose (CMRGlu) at baseline and during specific tasks previously required separate scans with the drawback high intrasubject variability. We aimed to validate a novel approach assessing metabolism task-specific changes in single measurement constant infusion <sup>18</sup>F-FDG. <b>Methods:</b> Fifteen healthy subjects underwent two PET measurements arterial blood sampling. As reference, CMRGlu was quantified from 60-min scan after...
Article Abstract Objective: Despite a broad arsenal of antidepressants, about third patients suffering from major depressive disorder (MDD) do not respond sufficiently to adequate treatment. Using the data pool Group for Study Resistant Depression and machine learning, we intended draw new insights featuring 48 clinical, sociodemographic, psychosocial predictors treatment outcome. Method: Patients were enrolled starting January 2000 diagnosed according DSM-IV. Treatment-resistant depression...
Abstract Serotonin neurotransmission may impact the etiology and pathology of attention-deficit hyperactivity disorder (ADHD), partly mediated through single nucleotide polymorphisms (SNPs). We propose a multivariate, genetic positron emission tomography (PET) imaging classification model for ADHD healthy controls (HC). Sixteen patients with 22 HC were scanned by PET to measure serotonin transporter (SERT‘) binding potential [ 11 C]DASB. All subjects genotyped thirty SNPs within HTR1A,...
Previous studies suggest that transcranial magnetic stimulation exerts antidepressant effects by altering functional connectivity (FC). However, knowledge about this mechanism is still limited. Here, we aimed to investigate the effect of bilateral sequential theta-burst (TBS) on FC in treatment-resistant depression (TRD) a sham-controlled longitudinal study. TRD patients (n = 20) underwent three-week treatment intermittent TBS left and continuous right dorsolateral prefrontal cortex (DLPFC)....
Selective serotonin reuptake inhibitors (SSRIs) modulate serotonergic neurotransmission by blocking of from the extracellular space. Up to now, it has been unclear how SSRIs achieve their antidepressant effect. However, task-based and resting state functional MRI studies, have demonstrated connectivity changes between brain regions. Here, we use positron emission tomography (PET) quantify SSRI's main target, transporter (SERT), assess treatment-induced molecular in interregional relation...
Abstract Background Major threatening life events can impact the functionality of brain networks as revealed by neuroimaging studies [1]. The COVID-19 pandemic was an unprecedented global event that associated with extensive restrictions to daily life. These measures greatly challenged whole population including specific subgroups such patients depression. Here, we investigated pandemic-associated lockdowns on functional connectivity (FC) major networks. Aims and objectives We hypothesized...
Attention-deficit/hyperactivity disorder (ADHD) research has long focused on the dopaminergic system's contribution to pathogenesis, although results have been inconclusive. However, a case made for involvement of noradrenergic system, which modulates cognitive processes, such as arousal, working memory, and response inhibition, all are typically affected in ADHD. Furthermore, norepinephrine transporter (NET) is an important target frequently prescribed medication Therefore, NET suggested...
Abstract Although the sex steroid hormone testosterone is integrally involved in development of language processing, ethical considerations mostly limit investigations to single administrations. To circumvent this issue we assessed influence continuous high‐dose application adult female‐to‐male transsexuals. Subjects underwent magnetic resonance imaging before and after 4 weeks treatment, with each scan including structural, diffusion weighted functional imaging. Voxel‐based morphometry...
Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking neuronal activity yields important insight how responds to stimulation. We specifically investigated changes in glucose metabolism, connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening eyes right finger tapping had elicited an increased metabolism primary visual motor...
Neural plasticity is a complex process dependent on neurochemical underpinnings. Next to the glutamatergic system which contributes memory formation via long-term potentiation (LTP) and depression (LTD), main inhibitory neurotransmitter, GABA crucially involved in neuroplastic processes. Hence, we investigated changes glutamate levels brain healthy participants performing an associative learning paradigm. Twenty (10 female, 25 ± 5 years) underwent paired multi-voxel magnetic resonance...
Impaired cognitive flexibility represents a widespread symptom in psychiatric disorders, including major depressive disorder (MDD), disease, characterized by an imbalance of neurotransmitter concentrations. While memory formation is mostly associated with glutamate, also gamma-Aminobutyric acid (GABA) and serotonin show attributions complex interplay between systems. Treatment selective reuptake inhibitors (SSRIs) does not solely affect the serotonergic system but shows downstream effects on...
Abstract Attention deficit hyperactivity disorder (ADHD) is a heterogeneous with strong genetic component. The norepinephrine transporter (NET) key target for ADHD treatment and the NET gene has been of high interest as possible modulator pathophysiology. Therefore, we conducted an imaging genetics study to examine effects single nucleotide polymorphisms (SNPs) within on nondisplaceable binding potential (BP ND ) in patients healthy controls (HCs). Twenty adult 20 HCs underwent ( S,S ‐ [ 18...
Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well increased motor activity, all exemplifying key symptoms of ADHD.The main objectives this positron emission tomography (PET) study were investigate the serotonin transporter binding potential (SERT BP ND ) in patients with ADHD assess associations SERT between brain regions.25 medication-free (age 6 SD; 32.39 10.15; 10 females) without any psychiatric comorbidity 25 age sex matched...
Regional differences in posttranscriptional mechanisms may influence vivo protein densities. The association of positron emission tomography (PET) imaging data from 112 healthy controls and gene expression values the Allen Human Brain Atlas, based on post-mortem brains, was investigated for key serotonergic proteins. PET binding intensities were correlated main inhibitory (5-HT1A) excitatory (5-HT2A) serotonin receptor, transporter (SERT) as well monoamine oxidase-A (MAO-A), using Spearman's...
Animal studies using selective serotonin reuptake inhibitors (SSRIs) and learning paradigms have demonstrated that is important for flexibility in executive functions learning. SSRIs might facilitate relearning through neuroplastic processes thus exert their clinical effects psychiatric diseases where cognitive functioning affected. However, translation of these mechanisms to humans missing. In this randomized placebo-controlled trial, we assessed functional brain activation during memory...
Theta-burst stimulation (TBS) represents a brain technique effective for treatment-resistant depression (TRD) as underlined by meta-analyses. While the methodology undergoes constant refinement, bilateral of dorsolateral prefrontal cortex (DLPFC) appears promising to restore left DLPFC hypoactivity and right hyperactivity found in depression. The post-synaptic inhibitory serotonin-1A (5-HT1A) receptor, also occurring DLPFC, might be involved this mechanism action. To test hypothesis, we...