A5076995446- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Traumatic Brain Injury Research
- Motor Control and Adaptation
- Visual perception and processing mechanisms
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Gut microbiota and health
- Diet and metabolism studies
- Neuroscience and Music Perception
QIMR Berghofer Medical Research Institute
2016-2025
The University of Queensland
2015-2025
Brain (Germany)
2019-2023
Enel (Italy)
2023
Allen Institute for Brain Science
2013-2017
Queens University
2017
Columbia University
2016
The University of Melbourne
2008-2012
Melbourne Health
2009-2012
University of Lausanne
2007-2009
Significance Large-scale organizational properties of brain networks mapped with functional magnetic resonance imaging have been studied in a time-averaged sense. This is an oversimplification. We demonstrate that activity between multiple pairs spatially distributed regions spontaneously fluctuates and out correlation over time globally coordinated manner, giving rise to sporadic intervals during which information can be efficiently exchanged neuronal populations. argue dynamic fluctuations...
Intelligence is a fundamental ability that sets humans apart from other animal species. Despite its importance in defining human behaviour, the neural networks responsible for intelligence are not well understood. The dominant view neuroimaging work suggests intelligent performance on range of tasks underpinned by segregated interactions fronto-parietal network brain regions. Here we asked whether associated with ubiquitous, or emerge more widespread associations task-free context. First...
Our capacity for higher cognitive reasoning has a measurable limit. This limit is thought to arise from the brain's flexibly reconfigure interactions between spatially distributed networks. Recent work, however, suggested that reconfigurations of task-related networks are modest when compared with intrinsic "resting-state" network architecture. Here we combined resting-state and task-driven functional magnetic resonance imaging examine how flexible, task-specific associated increasing...
Adaptive brain function requires that sensory impressions of the social and natural milieu are dynamically incorporated into intrinsic activity. While dynamic switches between states have been well characterised in resting state acquisitions, remodelling these transitions by engagement naturalistic stimuli remains poorly understood. Here, we show temporal dynamics states, as measured fMRI, reshaped from predominantly bistable two relatively indistinct at rest, toward a sequence well-defined...
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory depression, however, therapeutic outcomes vary. Mounting evidence suggests that clinical response relates to functional connectivity with subgenual cingulate (SGC) at precise DLPFC site. Critically, SGC-related network architecture shows considerable interindividual variation across spatial extent DLPFC, indicating connectivity-based target...
Background Internet addiction has become increasingly recognized as a mental disorder, though its neurobiological basis is unknown. This study used functional neuroimaging to investigate whole-brain connectivity in adolescents diagnosed with internet addiction. Based on changes seen other related disorders, it was predicted that disruptions would be most prominent cortico-striatal circuitry. Methods Participants were 12 and 11 healthy comparison subjects. Resting-state magnetic resonance...
Attention-deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention and hyperactivity/impulsivity that often persist in adulthood. There a growing consensus ADHD associated with abnormal function diffuse brain networks, but such alterations remain poorly characterized. Using resting-state functional magnetic resonance imaging, we multivariate (complex network measures), bivariate (network-based statistic), univariate (regional homogeneity) properties networks...
Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functional and structural brain networks. However, relationship between deficits remains unclear. To answer this question, patients with established matched healthy controls underwent resting-state diffusion weighted imaging. The network-based statistic was used to characterize between-group differences whole-brain connectivity. Indices white matter integrity were then...
ABSTRACT Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter secondary to chronic opiate use. However, few studies have quantitavely examined deficits (OA). Here, we investigated microstructure OA using diffusion tensor imaging (DTI). We performed voxel‐wise analysis of fractional anisotropy (FA) 24 participants 29 healthy controls. The group showed reduced FA...
White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across studies is moderate. In this study, neuroimaging was used to investigate white pathology and its impact on whole-brain connectivity in one largest samples patients schizophrenia. Fractional anisotropy (FA) mean diffusivity (MD) were compared between or schizoaffective disorder (n = 326) age-matched healthy controls 197). Between-group differences FA MD assessed...
Within the primate visual system, areas at lower levels of cortical hierarchy process basic features, whereas those higher levels, such as frontal eye fields (FEF), are thought to modulate sensory processes via feedback connections. Despite these functional exchanges during perception, there is little shared activity between early and late regions rest. How interactions emerge encompassing distinct remains unknown. Here we combined neuroimaging, non-invasive stimulation computational...
Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain networks. This study aims to model the dynamics in individuals with schizophrenia and investigate whether attributes these associate disorder's behavioral cognitive deficits. A hidden Markov (HMM) was inferred resting-state functional magnetic resonance imaging (fMRI) data temporally concatenated across (n = 41) healthy comparison 41). Under HMM, fluctuations fMRI...
Although different aspects of neuroplasticity can be quantified with behavioral probes, brain stimulation, and imaging assessments, no study to date has combined all these approaches into one comprehensive assessment plasticity. Here, 24 healthy right-handed participants practiced a sequence finger-thumb opposition movements for 10 min each day their left hand. After 4 weeks, performance the improved significantly (P < 0.05 FWE) relative matched control sequence, both (mean increase: 53.0%...