A5056925093- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Neural dynamics and brain function
Medical University of Vienna
2021-2022
Increases in the volume of amygdala and hippocampus after electroconvulsive therapy (ECT) are among most robust effects known to brain-imaging field. Recent advances segmentation substructures these regions allow for novel insights on relationship between brain structure clinical outcomes ECT.We aimed provide a comprehensive synthesis evidence available changes ECT, including recently published data hippocampal subfields.A meta-analysis studies was carried out using random-effects models...
Impaired cognitive flexibility represents a widespread symptom in psychiatric disorders, including major depressive disorder (MDD), disease, characterized by an imbalance of neurotransmitter concentrations. While memory formation is mostly associated with glutamate, also gamma-Aminobutyric acid (GABA) and serotonin show attributions complex interplay between systems. Treatment selective reuptake inhibitors (SSRIs) does not solely affect the serotonergic system but shows downstream effects on...
Abstract Strategies to personalize psychopharmacological treatment promise improve efficacy and tolerability. We measured serotonin transporter occupancy immediately after infusion of the widely prescribed P-glycoprotein substrate citalopram assessed what extent variants ABCB1 gene affect drug target engagement in brain vivo. A total 79 participants (39 female) including 31 patients with major depression 48 healthy volunteers underwent two PET/MRI scans tracer [ 11 C]DASB placebo-controlled...
Abstract Background The brain-derived neurotrophic factor (BDNF) has been implicated in processes essential for neuroplasticity. Learning and serotonin reuptake inhibitors (SSRI) foster neuronal reorganization, a mechanism potentially related to BDNF. This study aims assess the effects of associative learning escitalopram on serum BDNF (sBDNF) levels, gain further knowledge their dynamic interplay. Methods For three weeks, 37 participants performed one two paradigms with either emotional or...