A5074136047- Forensic Toxicology and Drug Analysis
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Poisoning and overdose treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Treatment of Major Depression
- Mass Spectrometry Techniques and Applications
- Anesthesia and Pain Management
- Analytical Chemistry and Chromatography
- Neuroscience and Neuropharmacology Research
- Pharmacology and Obesity Treatment
- Diabetes Treatment and Management
- Epilepsy research and treatment
- Advanced Chemical Sensor Technologies
- Nausea and vomiting management
- Opioid Use Disorder Treatment
- Functional Brain Connectivity Studies
- Alcohol Consumption and Health Effects
- Antibiotic Resistance in Bacteria
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Analytical chemistry methods development
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Lipoproteins and Cardiovascular Health
Medical University of Vienna
2015-2024
University of Leeds
2021
Orthopaedic Hospital Speising
2021
Statistics Austria
2020
University of Vienna
1995-2017
Universität Hamburg
2007-2008
University Medical Center Hamburg-Eppendorf
2007-2008
Asklepios Kliniken Hamburg
2008
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related (ALD) cannot reliably be distinguished by routine diagnostics, the role of alcohol consumption in metabolic dysfunction-associated (MAFLD) remains unclear. We investigated patients with presumed NAFLD ALD using novel objective markers.
Abstract Background Our recent drug interaction trial with clopidogrel shows that morphine decreases the concentrations and pharmacodynamic effects of clopidogrel, which could lead to treatment failure in susceptible individuals. We hypothesized consequences drug–drug interactions would be less between ticagrelor. Materials methods Twenty‐four healthy subjects received a loading dose 180 mg ticagrelor together placebo or 5 intravenously randomized, double‐blind, placebo‐controlled, crossover...
Morphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction. To clarify whether more potent P2Y12-inhibitors may provide an effective alternative, we examined drug–drug interactions between morphine prasugrel. Twelve healthy volunteers received 60 mg prasugrel with placebo or 5 intravenously a randomized, double-blind, placebo-controlled, cross-over trial. Pharmacokinetics were determined by liquid chromatography tandem...
Abstract Background Invasive aspergillosis is a severe fungal infection that affects multiple organ systems including the CNS and lungs. Isavuconazole, novel triazole antifungal agent, has demonstrated promising activity against Aspergillus spp. However, data on penetration of isavuconazole into ELF intracellular accumulation remain limited. Materials methods We conducted prospective single-centre pharmacokinetic (PK) study in 12 healthy volunteers. Subjects received seven doses 200 mg to...
Objective: To describe our experience with the use of percutaneous cardiopulmonary bypass as a therapy for cardiac arrest in an adult patient intoxicated verapamil. Design: Case report. Setting: Emergency department university hospital. Patient: A after severe verapamil intoxication. Interventions: Percutaneous and theophylline therapy. Report: 41-yr-old white male had taken 4800-6400 mg suicide attempt. On arrival ambulance physician, was conscious weak palpable pulses transported to nearby...
Converging evidence suggests that ketamine elicits antidepressant effects via enhanced neuroplasticity precipitated by a surge of glutamate and modulation GABA. Magnetic resonance spectroscopic imaging (MRSI) illustrates changes to cerebral GABA immediately following administration during dissociation. However, few studies assess subacute in the first hours application, when ketamine's emerge. Moreover, metabolites implicated its develop this timeframe. Thus, study aimed investigate Glx...
The present study was undertaken to investigate the pharmacokinetics of 1,8-cineol in human subjects during prolonged inhalation. results showed that is well absorbed from breathing air, with a peak plasma concentration after approximately 18 min. elimination this fragrance compound blood biphasic, mean distribution half-life 6.7 min and an 104.6
Abstract Background Histaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis rats, guinea pigs, and rabbits. Heparin released during mast cell degranulation the gastrointestinal tract might liberate DAO from heparin‐sensitive storage sites. release has not been demonstrated humans. Methods Plasma DAO, tryptase, histamine concentrations four events were determined at multiple serial time points two patients with systemic...
Abstract Schizophrenia is characterized by increased behavioral and neurochemical responses to dopamine-releasing drugs. This prompted the hypothesis of psychosis as a state “endogenous” sensitization dopamine system although exact basis dopaminergic disturbances possible role prefrontal cortical regulation have remained uncertain. To show that patients with first-episode release more upon amphetamine-stimulation than healthy volunteers, reveal for first time prospective induced repeated...
Comprehensive description of ketamine's molecular binding profile becomes increasingly pressing as use in real-life patient cohorts widens. Animal studies attribute a significant role the substance's antidepressant effects to serotonergic system. The serotonin transporter is highly relevant target this context, because it central depressive pathophysiology and treatment. This is, our knowledge, first study investigating vivo humans. Twelve healthy subjects were assessed twice using [11C]DASB...
Exposure to bioactive compounds from nutrition, pharmaceuticals, environmental contaminants or other lifestyle habits may affect the human organism. To gain insight into effects of these influences, as well fundamental biochemical mechanisms behind them, individual molecular profiling seems be a promising tool and support further development predictive, preventive personalised medicine.We developed an assay, called metabo-tip for analysis sweat, collected fingertips, using mass...
Combining mouse experiments with big data analysis of the Austrian population, we investigated association between high-dose statin treatment and bone quality.The microarchitecture femur vertebral body L4 was measured in male ovariectomized female mice on a high-fat diet containing simvastatin (1.2 g/kg). A sex-specific matched health insurance claims using multiple logistic regression models conducted (simvastatin 60-80 mg/day vs. controls; males: n = 138,666; females: 155,055).High-dose...
Only limited data are available regarding the treatment of critically ill patients with clopidogrel. This trial investigated effects and drug concentrations cytochrome P450 (CYP450) activated prodrug clopidogrel ( n = 43) half‐life similarly metabolized pantoprazole 16) in patients. ADP‐induced aggregometry whole blood classified 74% (95% confidence intervals 59–87%) as poor responders 43), 65% (49–79%) responded poorly according to vasodilator‐stimulated phosphoprotein phosphorylation...
Introduction: Gamma-hydroxybutyric acid (GHB, "liquid ecstasy") and its legal pro-drugs gamma-butyrolactone 1,4-butanediol are gaining in importance as recreational drugs Germany.The effects of these substances comparable with those alcohol or benzodiazepines.Because the wide availability GHB physicians increasingly being confronted cases intoxication.Methods: This review is based on a selective literature search well authors' own experience information provided by GIZ-Nord Poisons Centre,...
Summary Background Caudal blockade, although an important technique of pediatric regional anesthesia, is rarely used in children heavier than 30 kg. This reservation due to anatomical concerns and lack pharmacokinetic data. We therefore set out evaluate, patients weighing 30−50 kg, the feasibility ultrasound‐guided caudal blockade pharmacokinetics caudally administered ropivacaine. Methods Twenty consecutive were included. General anesthesia was ensure a secured airway. For punctures, we...
Telavancin is a novel lipoglycoprotein antibiotic with MRSA activity. To date, tissue pharmacokinetics (PK) and plasma protein binding of the drug are insufficiently described.To investigate PK telavancin in healthy volunteers.Eight male subjects received single dose 10 mg/kg body weight as an intravenous infusion over 1 h. At defined timepoints before up to 24 h after treatment, total concentrations were measured plasma. Additionally, unbound levels determined plasma, muscle subcutis by...
Carbon monoxide, a gaseous activator of soluble guanylyl cyclase formed by subtype the enzyme heme oxygenase designated oxygenase-2 in vascular endothelium, has been found to dilate blood vessels independently from nitric oxide. Because parallels between oxide and carbon we speculated that estrogen might affect monoxide production endothelium. Endothelial cells human origin (umbilical vein uterine artery) were incubated for 4 or 24 h with 10−12–10−6m 17β-estradiol. 17β-Estradiol, at...