A5029660812- Cardiac and Coronary Surgery Techniques
- Blood transfusion and management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Estrogen and related hormone effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Blood donation and transfusion practices
- Intramuscular injections and effects
- Pelvic floor disorders treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Endometriosis Research and Treatment
- Platelet Disorders and Treatments
- Acute Myocardial Infarction Research
- Blood properties and coagulation
- Atrial Fibrillation Management and Outcomes
- Menopause: Health Impacts and Treatments
- Cardiac Valve Diseases and Treatments
- Hormonal and reproductive studies
- Simulation-Based Education in Healthcare
- Iron Metabolism and Disorders
Karl Landsteiner University of Health Sciences
2021-2024
Universitätsklinikum Tulln
2021
Nuremberg Hospital
2012
Medical University of Vienna
2004-2011
Karl Landsteiner Society
2011
Deutsches Herzzentrum München
1997-2010
University of Vienna
1999-2009
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2009
Ludwig-Maximilians-Universität München
2006
Deutsches Herzzentrum der Charité
1987-2004
Intraoperative administration of the proteinase inhibitor aprotinin causes reduction in blood loss and homologous requirement patients undergoing cardiac surgery. To ascertain blood-saving effect to obtain further information about mode action, 40 primary myocardial revascularization were randomly assigned receive either or placebo treatment. Aprotinin was given as a bolus 2 x 10(6) kallikrein inactivator units (KIU) before surgery followed by continuous infusion 5 10(5) KIU/h during...
The activity of heme oxygenase enzymes (HOs) is responsible for the endogenous source carbon monoxide (CO). Their activities can be inhibited by tin protoporphyrin-IX (SnPPIX). Recent data indicate involvement HOs in regulation angiogenesis. Here, we investigated role HO pathway production and angiogenic vascular endothelial growth factor (VEGF) cells treated with SnPPIX, or cultured presence a CO-releasing molecule (CO-RM). Addition CO-RM induction HO-1 hemin resulted threefold elevation CO...
Background Aprotinin causes a prolongation of the celite-activated clotting time (CACT), but not kaolin-activated (KACT). Therefore, concern has been raised regarding reliability CACT to monitor anticoagulation in presence aprotinin. The current study was designed test efficacy aprotinin improve anticoagulation, and investigate whether reflects true or is an vitro artifact. To elucidate this antithrombotic effect aprotinin, done patients prone reduced intraoperative heparin sensitivity....
The protease inhibitor aprotinin interacts with plasmin and kallikrein, which are generated in cardiac surgery during cardiopulmonary bypass (CPB). influence of high-dose application (2 million kallikrein inactivator units given i. v. at the beginning anaesthesia followed by a 500 000 KIU/h infusion throughout operation additional 2 millions KIU added to priming oxygenator) on perioperative blood loss donor requirement was studied 152 adult surgical patients. This group compared 317 patients...
To determine whether women with extremely low-serum anti-Mullerian hormone (AMH) levels (<0.1-0.4 ng/ml) still demonstrate live birth potential assisted reproduction and such is age dependent.Between January 2006 October 2009, 128 consecutive infertility patients AMH ≤0.4 ng/ml were retrospectively evaluated for pregnancy chances rates after IVF.Patients presented at a mean (±SD) of 40.8 ± 4.1 years, baseline FSH 15.7 11.1 mIU/ml 0.2 0.1 ng/ml. One hundred twenty-eight underwent total 254...
Estrogen, largely produced in testis and adrenal gland, may play important roles male reproduction. Most of the effects estrogens are mediated by binding estrogen to one or both two receptor (ER) subtypes alpha beta. Recently, they have been described testis, prostate, efferent ducts, mostly rodents. The goal this study was prove evidence ERs human corpus cavernosum urethra, exploring protein expression these receptors immunohistochemistry. Corpus spongiosum smooth muscle immunoreactive for...
Mesenchymal stem cells (MSCs) are primary candidates in tissue engineering and cell therapies due to their intriguing regenerative immunomodulatory potential. Their ability self-assemble into three-dimensional (3D) aggregates further improves some of therapeutic properties, e.g., differentiation potential, secretion cytokines, homing capacity after administration. However, high hydrodynamic shear forces the resulting mechanical stresses within commercially available dynamic cultivation...
Mesenchymal stem cells (MSCs) are the most prominent type of adult for clinical applications. Three-dimensional (3D) cultivation MSCs in biomimetic hydrogels provides a more physiologically relevant microenvironment vitro testing and modeling, thus overcoming limitations traditional planar methods. Cellulose nanofibers an excellent candidate biomaterial synthesis this application, due to their biocompatibility, tunable properties, availability, low cost. Herein, we demonstrate capacity...
Estrogen-induced loss of estrogen receptor (ER) α expression limits responsiveness in many target cells. However, whether such a mechanism contributes to changes vascular endothelial ERα and/or ERβ levels is unclear. Using RT-PCR assays, we did not find any regulation or mRNA human uterine artery cell (HUAEC) nuclear extracts on stimulation with 17β-estradiol for 1 2 h. By contrast, Western analysis HUAEC revealed that was capable down-regulating both and protein starting h after treatment,...
AMH's reported stability during periods of hormonal change makes it a practical tool in assessing ovarian reserve. However, AMH declines with age and age-specific cut-offs remain to be established women proven fertility. This study aims determine ranges Two hundred-ten fertile women, aged 18-40 years, were prospectively recruited for measurements within 14 days after delivery stratified into 3 groups (18-30, 31-36 37-40 years). Eligibility required spontaneous conception maximal period six...
Carbon monoxide, a gaseous activator of soluble guanylyl cyclase formed by subtype the enzyme heme oxygenase designated oxygenase-2 in vascular endothelium, has been found to dilate blood vessels independently from nitric oxide. Because parallels between oxide and carbon we speculated that estrogen might affect monoxide production endothelium. Endothelial cells human origin (umbilical vein uterine artery) were incubated for 4 or 24 h with 10−12–10−6m 17β-estradiol. 17β-Estradiol, at...
To evaluate whether locally applied vaginal estrogen affects prolapse-associated complaints compared with placebo treatment in postmenopausal women prior to surgical prolapse repair.Randomised, double-masked, placebo-controlled, multicentre study.Urogynaecology unit at the Medical University of Vienna and Hospital Tulln.Postmenopausal symptomatic pelvic organ planned repair.Women were randomly assigned local cream or 6 weeks preoperatively.The primary outcome was differences subjective after...