A5073544981- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2016-2025
Molecular Oncology (United States)
1997-2018
Universitätsklinik für Frauenheilkunde und Geburtshilfe
1994-2018
Comprehensive Blood & Cancer Center
2018
Ludwig Boltzmann Gesellschaft
2010-2017
Ludwig Boltzmann Institute Applied Diagnostics
2017
Ludwig Boltzmann Cluster for Cardiovascular Research
2009-2016
Johns Hopkins University
2015
Charité - Universitätsmedizin Berlin
2006-2013
Circular RNAs are a recently (re-)discovered abundant RNA species with presumed function as miRNA sponges, thus part of the competing endogenous network. We analysed expression circular and linear proliferation in matched normal colon mucosa tumour tissues. predicted >1,800 proved existence five randomly chosen examples using RT-qPCR. Interestingly, ratio to isoforms was always lower compared samples even colorectal cancer cell lines. Furthermore, this correlated negatively index. The...
Background. Immunomagnetic EpCAM based methods are used to enrich circulating tumor cells (CTCs) in metastatic breast cancer (mBC) patients. negative CTCs may be missed. We addressed the question of reliability an dependent assay CTCs. Methods. To elucidate this issue, our study has been designed assess two different CTC enrichment technologies (i) positive (+) and cell lines (ii) mBC patients dependency on their respective expression. These encompass one anti-EpCAM immunomagnetic...
C Schneeberger, P Speiser, F Kury, and R Zeillinger Department of Obstetrics Gynecology, University Vienna, Austria.
Abstract Purpose: To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC). Experimental Design: In a multicenter study, preoperative CRP was evaluated 623 EOC. Results were correlated clinical data. Results: Mean (SD) 3.6 (4.8) mg/dL. Serum significantly associated International Federation of Gynecologists and Obstetricians stage (P < 0.001) postoperative residual tumor mass but not histologic grade = 0.1) type 0.7), patients'...
Type II ovarian cancer (OC) and endometrial (EC) are generally diagnosed at an advanced stage, translating into a poor survival rate. There is increasing evidence that Müllerian duct cancers may exfoliate cells. We have established approach for lavage of the uterine cavity to detect shed cells.Lavage was used obtain samples from 65 patients, including 30 with OC, five EC, three other malignancies, 27 benign lesions involving gynecologic organs. These samples, as well corresponding tumor...
High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant molecules minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian using ultra-accurate Duplex Sequencing to identify TP53 mutations uterine lavage. However, addition tumor DNA, we also detect low-frequency nearly all lavages from women with and without cancer. These increase age share selection traits clonal commonly found human...
Evidence of the involvement cyclin genes in genetic alterations human cancer is growing. In present study, we investigated amplification, breast and ovarian cancer, 5 genes; A, D1, D2, D3 E. For this purpose, a series 1,171 237 tumors tested for DNA amplification by Southern blotting subset 132 22 cancers were analyzed RNA expression levels slot-blot Northern blotting. tumors, only D1 was found to be activated sizeable fraction (amplification 12.6%, overexpression 19%). Cyclin D3, E never,...
Studies have shown that microvessel density influences breast-cancer prognosis. Since tumor angiogenesis is considered to be substantially affected by the excretion of vascular endothelial growth factor (VEGF) from cells, we examined whether VEGF concentration different in malignant and non-malignant breast tissue. It was also interest discover intratumoral disease-free survival (DFS) patients. Analysis based on 120 tissue specimens taken fibromas (n = 23), normal epithelial adjacent 8)...
Abstract Dysregulation of apoptosis may support tumorigenesis by allowing cells to live beyond their normally intended life span. The various receptors for tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) are located on chromosome 8p21.2, a region frequently deleted in ovarian cancer. Lack expression TRAIL receptor 1 (death 4, DR4) correlates with resistance TRAIL-induced cancer cells. Reconstitution DR4 the TRAIL-resistant A2780 cell line was investigated demethylating agent...
Abstract Despite strong homology, the roles of TP53 and TP73 in tumorigenesis seem to be fundamentally different. In contrast TP53, tumor-associated overexpression many different cancers, combined with virtual absence inactivating mutations lack a cancer phenotype null mouse are inconsistent suppressor function but instead support an oncogenic function. The discovery NH2-terminally truncated p73 isoforms, collectively called ΔTAp73, is now focus intense interest because they act as potent...
Abstract Purpose: Genetic polymorphisms of cytokine-encoding genes are known to predispose malignant disease. Interleukin (IL)-1 and IL-6 crucially involved in breast carcinogenesis. Whether the encoding IL-1 (IL1) (IL6) also influence cancer risk is unknown. Experimental Design: In present case-control study, we ascertained three IL1 gene cluster [−889 C/T polymorphism IL1α (IL1A), −511 IL1β promoter (IL1B promoter), a exon 5 5)], an 86-bp repeat intron 2 receptor antagonist (IL1RN), −174...
Abstract Ovarian carcinoma has the highest mortality rate among gynaecological malignancies. In this project, we investigated hypothesis that molecular markers are able to predict outcome of ovarian cancer independently classical clinical predictors, and these can be validated using independent data sets. We applied a semi‐supervised method for prediction patient survival. Microarrays from cohort 80 carcinomas (TOC cohort) were used development predictive model, which was then evaluated in...
The presence of circulating tumor cells (CTC) in the peripheral blood cancer patients has been described for various solid tumors and their clinical relevance shown. CTC detection based on analysis epithelial antigens might be hampered by genetic heterogeneity primary loss antigens. Therefore, we aimed to identify new gene markers PCR-based female patients.Gene expression 38 cell lines (breast, ovarian, cervical endometrial) 10 mononuclear (PBMC) samples from healthy donors was measured...
<h3>Objective</h3> The objective of the study was to evaluate prognostic impact residual tumor size after cytoreductive surgery in patients with epithelial ovarian cancer. <h3>Methods</h3> In this prospective, multicenter study, 226 cancer (International Federation Gynecology and Obstetrics stages IIA–IV) were included. Patients treated adjuvant platinum-based chemotherapy. Univariate multivariable survival analyses performed investigate on progression-free overall survival. <h3>Results</h3>...
Small cell lung cancer (SCLC) represents 15% of cancers and is characterized by early dissemination, development chemoresistance a poor prognosis. A host diverse drugs failed invariably its mechanisms global have not been so far. SCLC the prototype an aggressive highly metastatic tumor which ultimately refractory to any treatment. High numbers circulating cells (CTCs) allowed us establish 5 CTC lines (BHGc7, 10, 16, 26 UHGc5) from patients with recurrent SCLC. These exhibit typical markers...