A5002969658- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Receptor Mechanisms and Signaling
- Substance Abuse Treatment and Outcomes
- Opioid Use Disorder Treatment
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Regulation of Appetite and Obesity
- Treatment of Major Depression
- Forensic Toxicology and Drug Analysis
- Prenatal Substance Exposure Effects
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Eating Disorders and Behaviors
- Parkinson's Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Pain Management and Opioid Use
- Schizophrenia research and treatment
National Institute on Drug Abuse
2016-2025
National Institutes of Health
2016-2025
National Institute on Alcohol Abuse and Alcoholism
2016-2025
University of Copenhagen
2024
Rigshospitalet
2024
Frederiksberg Hospital
2024
AID Atlanta
2024
Columbia University
2005-2023
Case Western Reserve University
2023
Office of the Director
2006-2022
The distribution volume ratio (DVR), which is a linear function of receptor availability, widely used as model parameter in imaging studies. DVR corresponds to the DV receptor-containing region nonreceptor and generally requires measurement an arterial input function. Here we propose graphical method for determining that does not require blood sampling. This uses data from with average tissue-to-plasma efflux constant k 2 approximate plasma integral. Data positron emission tomography studies...
A graphical method of analysis applicable to ligands that bind reversibly receptors or enzymes requiring the simultaneous measurement plasma and tissue radioactivities for multiple times after injection a radiolabeled tracer is presented. It shown there time t† which plot f t 0 ROI( t') dt'/ROI( t) versus C p ( (where ROI are functions describing variation radioactivity radioactivity, respectively) linear with slope corresponds steady-state space ligand plus volume, V . For two-compartment...
The ability of drugs abuse to increase dopamine in nucleus accumbens underlies their reinforcing effects. However, preclinical studies have shown that with repeated drug exposure neutral stimuli paired the (conditioned stimuli) start by themselves, which is an effect could underlie drug-seeking behavior. Here we test whether increases occur conditioned human subjects addicted cocaine and this associated craving. We tested eighteen cocaine-addicted using positron emission tomography...
T he rate of death from over- doses prescription opioids in the United States more than quadrupled between 1999 and 2010 (see graph), far exceeding combined toll cocaine heroin overdoses. 1In alone, were involved 16,651 overdose deaths, whereas was implicated 3036.Some 82% deaths due to An audio interview with Dr.
Drugs and food exert their reinforcing effects in part by increasing dopamine (DA) limbic regions, which has generated interest understanding how drug abuse/addiction relates to obesity. Here, we integrate findings from positron emission tomography imaging studies on DA's role obesity propose a common model for these two conditions. Both obesity, there is an enhanced value of one type reinforcer (drugs food, respectively) at the expense other reinforcers, consequence conditioned learning...
ing data at all or pooling using network meta-analysis, we chose the latter; indeed meta-analysis has been shown to potentially give more reliable results because of integration additional information. 5,6Although studies included in our review were from different sources, they randomized controlled trials and hence contrasts between treatment groups within each study should be comparable.In addition, focused only on CP/CPPS categories IIIA IIIB reduce heterogeneity due disease severity...