A5003531649- Obsessive-Compulsive Spectrum Disorders
- Treatment of Major Depression
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Neurotransmitter Receptor Influence on Behavior
- Posttraumatic Stress Disorder Research
- Autism Spectrum Disorder Research
- Body Image and Dysmorphia Studies
- Pharmacological Effects and Toxicity Studies
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Eating Disorders and Behaviors
- Neuroendocrine regulation and behavior
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Resilience and Mental Health
- Psychosomatic Disorders and Their Treatments
- Pharmaceutical studies and practices
- Functional Brain Connectivity Studies
Tel Aviv University
2016-2025
Sheba Medical Center
2016-2025
Ben-Gurion University of the Negev
2003-2022
Advanced Mental Health Care
2019-2022
University of California, Los Angeles
2019-2022
Herzliya Medical Center
2022
Universidade do Porto
2022
Arq Psychotrauma Expert Group
2020
Defence Research and Development Canada
2020
Academic College of Tel Aviv-Yafo
2020
In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002, World J Biol Psychiatry 3:171), recommendations for the pharmacological treatment anxiety disorder, obsessive-compulsive disorder (OCD) and post-traumatic stress (PTSD) are presented. Since publication first version guideline, substantial number new randomized controlled studies anxiolytics have been published. particular, more relapse prevention now available that show sustained efficacy anxiolytic...
As a response to the COVID-19 pandemic, many governments have introduced steps such as spatial distancing and "staying at home" curb its spread impact. The fear resulting from disease, 'lockdown' situation, high levels of uncertainty regarding future, financial insecurity raise level stress, anxiety, depression experienced by people all around world. Psychoactive substances other reinforcing behaviors (e.g., gambling, video gaming, watching pornography) are often used reduce stress anxiety...
Article Abstract Objectives: Very few studies have investigated clinical features associated with treatment-resistant depression (TRD) defined as failure of at least 2 consecutive antidepressant trials. The primary objective this multicenter study was to identify specific and demographic factors TRD in a large sample patients major depressive episodes that failed reach response or remission after adequate treatments. Method: A total 702 DSM-IV disorder, recruited from January 2000 February...
Objective. Anxiety disorders are frequently under-diagnosed conditions in primary care, although they can be managed effectively by general practitioners. Methods. This paper is a short and practical summary of the World Federation Biological Psychiatry (WFSBP) guidelines for pharmacological treatment anxiety disorders, obsessive–compulsive disorder (OCD) posttraumatic stress (PTSD) care. The recommendations were developed task force 30 international experts field based on randomized...
To examine the "serotonin hypothesis" of obsessive-compulsive disorder (OCD), we studied behavioral and neuroendocrine effects metachlorophenylpiperazine (mCPP), a serotonergic agonist, in patients with OCD healthy controls. Twelve 20 controls were given single dose 0.5 mg/kg mCPP, administered orally under double-blind, placebo-controlled, random-assignment conditions. Following but not following placebo, experienced transient marked exacerbation symptoms. Moreover, compared controls,...
Obsessive-compulsive disorder (OCD) is a chronic and disabling condition that often responds unsatisfactorily to pharmacological psychological treatments. Converging evidence suggests dysfunction of the cortical-striatal-thalamic-cortical circuit in OCD, previous feasibility study indicated beneficial effects deep transcranial magnetic stimulation (dTMS) targeting medial prefrontal cortex anterior cingulate cortex. The authors examined therapeutic effect dTMS multicenter double-blind...
The Internet is now all-pervasive across much of the globe. While it has positive uses (e.g. prompt access to information, rapid news dissemination), many individuals develop Problematic Use (PUI), an umbrella term incorporating a range repetitive impairing behaviours. can act as conduit for, and may contribute to, functionally behaviours including excessive compulsive video gaming, sexual behaviour, buying, gambling, streaming or social networks use. There growing public National health...
BackgroundObsessive Compulsive Disorder (OCD) is a chronic and disabling disorder with poor response to pharmacological treatments. Converging evidences suggest that OCD patients suffer from dysfunction of the cortico-striato-thalamo-cortical (CSTC) circuit, including in medial prefrontal cortex (mPFC) anterior cingulate (ACC).ObjectiveTo examine whether modulation mPFC-ACC activity by deep transcranial magnetic stimulation (DTMS) affects symptoms.MethodsTreatment resistant participants were...
The rapid advance of the coronavirus COVID-19 pandemic has significantly increased mortality but also demonstrated considerable potential to negatively impact mental health, including in young [1,2].From a public health perspective, guidelines for responding mass trauma and disaster emphasize importance focusing on resilience.In immediate ongoing response, consensus interventions that maintain calm, build community, sustain hope [3,4].
This is the third version of guideline World Federation Societies Biological Psychiatry (WFSBP) Task Force for Pharmacological Treatment Anxiety, Obsessive-Compulsive and Posttraumatic Stress Disorders (published in 2002, revised 2008).A consensus panel 33 international experts representing 22 countries developed recommendations based on efficacy acceptability available treatments. In total, 1007 RCTs treatment these disorders adults, adolescents, children with medications, psychotherapy...
Clomipramine is a potent serotonin reuptake blocker that decreases the symptoms of obsessive-compulsive disorder (OCD). To investigate whether clomipramine treatment in OCD affects brain serotonergic responsiveness, metachlorophenylpiperazine (mCPP), selective agonist, and placebo were given under double-blind conditions to nine patients with before after clomipramine. Unlike our previous observations marked transient increase obsessional anxiety following 0.5 mg/kg mCPP, readministration...
To evaluate the need for maintenance drug therapy in patients with obsessive-compulsive disorder, authors assessed 21 disorder who manifested sustained improvement during 5 to 27 months of clomipramine treatment and agreed participate a double-blind discontinuation study. Of 18 completed study, 16 had substantial recurrence symptoms by end 7-week placebo period. In addition, 11 significant increase depressive symptoms. Treatment duration before was not related frequency or severity symptom...