A5056826073- Treatment of Major Depression
- Schizophrenia research and treatment
- Psychiatric care and mental health services
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychology, Coaching, and Therapy
- Electroconvulsive Therapy Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neurotransmitter Receptor Influence on Behavior
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Health and Medical Studies
- Neuroscience and Neuropharmacology Research
- Mental Health Treatment and Access
- Dementia and Cognitive Impairment Research
- Psychoanalysis and Social Critique
- Obsessive-Compulsive Spectrum Disorders
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
Ludwig-Maximilians-Universität München
2014-2023
LMU Klinikum
1997-2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
1988-2011
Heinrich Heine University Düsseldorf
2011
Zimmer Biomet (Germany)
2010
Universität Ulm
2010
University of British Columbia Hospital
2007
Royal Victoria Infirmary
2007
Universitat de Barcelona
2007
University of Bonn
1989-2002
These updated guidelines are based on a first edition that was published in 2003, and have been edited with the available scientific evidence until end of 2008. Their purpose is to supply systematic overview all pertaining treatment acute mania adults. The data used for these extracted from MEDLINE EMBASE search, clinical trial database clinicaltrials.gov, recent proceedings key conferences, various national international guidelines. rigor categorised into six levels (A-F). As intended use,...
This is the third version of guideline World Federation Societies Biological Psychiatry (WFSBP) Task Force for Pharmacological Treatment Anxiety, Obsessive-Compulsive and Posttraumatic Stress Disorders (published in 2002, revised 2008).A consensus panel 33 international experts representing 22 countries developed recommendations based on efficacy acceptability available treatments. In total, 1007 RCTs treatment these disorders adults, adolescents, children with medications, psychotherapy...
Impairments in neuropsychological functioning have been described subjects clinically at high risk for psychosis, but the specific cognitive deficits different clinical high-risk groups remain to be elucidated. The German Research Network on Schizophrenia employs a heuristic 2-stage model: putatively late prodromal state (LPS), characterized by onset of attenuated positive or brief psychotic symptoms, and an early (EPS), mainly presence basic which are predictive psychosis within next 10 years.
This is the third version of guideline World Federation Societies Biological Psychiatry (WFSBP) Task Force for Pharmacological Treatment Anxiety, Obsessive-Compulsive and Posttraumatic Stress Disorders which was published in 2002 revised 2008.A consensus panel 34 international experts representing 22 countries developed recommendations based on efficacy acceptability treatments. In this version, not only medications but also psychotherapies other non-pharmacological interventions were...
Objective: To report the frequency of intra‐episode manic symptoms in depressive episodes, and to evaluate unipolar mixed state (DMS) as bipolar spectrum. Method: A total 958 (863 unipolar, 25 II, 70 I) in‐patients were assessed terms at admission, several clinical variables using standardized methods. Results: The (flight idea, logorrhea, aggression, excessive social contact, increased drive, irritability, racing thoughts, distractibility) was significantly higher depressives than...
OBJECTIVE: This study investigated the effect on brain morphology of an interleukin-1β genetic polymorphism (C→T transition at position –511) in patients with schizophrenia. METHOD: In vivo magnetic resonance imaging and genotype analysis were used examination 44 male schizophrenic 48 healthy comparison subjects. RESULTS: No association between schizophrenia was detected. Within patient group, bifrontal-temporal gray matter volume deficits generalized white tissue allele 2 carriers (genotype...
Abstract The serotonin 2C (HTR2C) and 1A (HTR1A) receptors have been involved in suicide‐related behaviors. We studied gene variants of both suicide attempters completers. sample was composed 167 German (affective spectrum n = 107, schizophrenia 35, borderline personality disorder 25), 92 Caucasian individuals who committed suicide, 312 healthy subjects, 152 Italian (major depression 68 bipolar 84), 131 volunteers. HTR2C (SNP: rs547536, rs2192372, rs6318, rs2428707, rs4272555, rs1801412)...
The aim of this study was to evaluate the efficacy and tolerability quetiapine combined with lithium or divalproex in treatment bipolar mania. Patients were randomized 6 weeks (up 800 mg/day) lithium/divalproex (Li/DVP) (target trough serum concentrations 0.7-1.0 mEq/L 50-100 microg/mL, respectively) placebo lithium/divalproex. Quetiapine+lithium/divalproex (n=104) showed a 2.0-point greater improvement on primary outcome (change from baseline Young Mania Rating Scale total score at day 21)...
Abstract Recent studies strongly support an association of the nicotinic acetylcholine receptor gene cluster CHRNA5 – CHRNA3 CHRNB4 with nicotine dependence (ND). However, precise genotype–phenotype relationship is still unknown. Clinical and epidemiological data on smoking behavior raise possibility that relevant variants may indirectly contribute to development ND by affecting cognitive performance in some smokers who consume for reasons “cognition enhancement.” Here, we tested seven...
First episode schizophrenia (FES) patients tend to be more responsive treatment. An adequate response has been associated with a favourable long-term course in FES patients. Yet, despite the generally very profile around one quarter of shows persisting symptoms psychosis. To improve outcome and psychosis great effort emerged identifying biological clinical variables non-response order identify non-responders as early possible adopt specific treatment strategies improving illness outcome....
Subtyping depression is important in order to further delineate biological causes of depressive syndromes. The aim this study was evaluate clinical and outcome characteristics distinct subtypes assess proportion features patients fulfilling criteria for more than one subtype. Melancholic, atypical anxious were assessed a naturalistic sample 833 inpatients using DSM-IV specifiers based on operationalized criteria. Baseline at discharge compared between their overlap. A substantial (16%)...
Paroxetine is a new compound in the group of selective serotonin-reuptake inhibitors. The results several open and double-blind control-group studies demonstrate clear antidepressive efficacy paroxetine. However, most data were collected samples outpatients. To overcome this restriction, six-week study, comparing 30 mg paroxetine with 150 amitriptyline per day, was performed sample inpatients suffering from major depression. Generally speaking, analysis 160 patients not able to statistically...