A5101641502- Bipolar Disorder and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Sedative Agents
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Streptococcal Infections and Treatments
- Schizophrenia research and treatment
- Hemodynamic Monitoring and Therapy
- Bartonella species infections research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Viral-associated cancers and disorders
- Personality Disorders and Psychopathology
- Wireless Power Transfer Systems
- Obsessive-Compulsive Spectrum Disorders
- Cardiovascular Conditions and Treatments
- Electroconvulsive Therapy Studies
- Parvovirus B19 Infection Studies
- Dysphagia Assessment and Management
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Blood Pressure and Hypertension Studies
Fukushima Medical University
2023-2025
University of Ulster
2015
Belfast City Hospital
2015
MRC Laboratory of Molecular Biology
2015
Kōchi University
2008
Ludwig-Maximilians-Universität München
2002-2003
Juntendo University
1991-1996
Okayama University
1993
Yamagata City Hospital Saiseikan
1993
Objective: To report the frequency of intra‐episode manic symptoms in depressive episodes, and to evaluate unipolar mixed state (DMS) as bipolar spectrum. Method: A total 958 (863 unipolar, 25 II, 70 I) in‐patients were assessed terms at admission, several clinical variables using standardized methods. Results: The (flight idea, logorrhea, aggression, excessive social contact, increased drive, irritability, racing thoughts, distractibility) was significantly higher depressives than...
BACKGROUND: The immune systems and chronic inflammation are implicated in the pathogenesis of dilated cardiomyopathy (DCM) heart failure. However, significance neutrophil extracellular traps (NETs) failure remains to be elucidated. METHODS: We enrolled consecutive 62 patients with idiopathic DCM who underwent endomyocardial biopsy. Biopsy specimens were subjected fluorescent immunostaining detect NETs, clinical outcome data collected. Ex vivo experiments conducted. RESULTS: numbers NETs per...
This study attempted to identify a specific personality disorder (PD) or PD cluster that independently worsens the 4‐month treatment outcome of major depression under adequate antidepressant. The material was 96 consecutive outpatients with depression. For Axis I and II diagnoses, Structured Clinical Interview for DSM‐III‐R (SCID) used. In material, presence any significantly worsened outcome. discriminant function analysis, conducted influences outcome, found number from only A criteria met...
Background It has been reported that the hepatic vein waveforms determined by abdominal ultrasonography can assess congestion in patients with heart failure (HF). However, parameter quantifies not established. We suggest venous stasis index (HVSI) as novel indicator to evaluate quantitatively. To examine clinical significance of HVSI HF, we aimed clarify associations parameters cardiac function and right catheterization, well prognosis, HF. Methods Results performed ultrasonography,...
The aim of this study is to establish a monitoring method prevent Epstein-Barr virus (EBV)-associated symptoms including post-transplant lymphoproliferative disorder (PTLD) that occur after pediatric renal transplantation.Circulating EBV loads were quantified by real-time PCR every 1 - 3 months grafting in 22 recipients (13 EBV-seronegative [R(-)] and 9 EBV-seropositive [R(+)] before grafting). peripheral blood cell populations non-specific activated killer cells (CD8+HLA-DR+ phenotype) 13...
Exercise intolerance in heart failure arises from multifactorial pathophysiological mechanisms. Hepatokines, liver-synthesized molecules, regulate systemic metabolisms peripheral tissues. We previously identified the hepatokine fetuin-A as being linked to liver hypoperfusion failure. Here, we investigated role of connecting cardiac-hepatic-peripheral interaction.
Objective: To explore the stability of diverse manic presentations across recurrences. Method: A total 253 bipolar patients who experienced two or more hospitalizations, because consecutive (or mixed) episodes, during a 20‐year period were included. All had second hospitalizations with an mean interval 773 days, while 126 and 91 third fourth intervals 1559 2237 days from index hospitalization, respectively. Seven symptom scores, previously factor‐validated, calculated. Results: Depressive...
What is known and objective Antibiotic resistance has become a global public health issue. Most antibiotics are prescribed in the community, although there less stewardship of such agents community compared to secondary tertiary care. Few studies have attempted examine prescribing practices General Practice its impact on antibiotic and, therefore, study was performed order compare susceptibilities commensal viridans group streptococci (VGS) obtained from patient cohorts Practices (GP), who...
Objective: To investigate the boundary between ICD‐10 mixed and manic episodes, which has apparently remained understudied. Method: In‐patients with ( n =36) episodes =145) were compared in terms of demographic, clinical, therapeutical outcome variables. Results: Of in‐patients episode, 26 (18%) had several depressive symptoms at admission. These patients (dysphoric patients) very similar to episode current symptomatic presentations clinical therapeutic variables, significantly different...
Introduction: It has been reported that day-to-day blood pressure (BP) variability (BPV) is associated with major adverse cardiac and cerebrovascular events (MACCE) in patients heart failure (HF). However, the clinical significance of beat-to-beat BPV unclear. Methods Results: We recruited data on HF who underwent nighttime pulse transit time (PTT)-based continuous BP measurement (n = 379, median age 71, male sex 53.6%). Standard deviation (SD) PTT-based was considered as BPV. The primary...
Background: We have previously demonstrated that neutrophil extracellular traps (NETs) in myocardial tissue are associated with cardiac dysfunction and adverse outcomes patients heart failure reduced ejection fraction. Here, we aimed to elucidate the underlying mechanisms clarify whether inhibiting NETs could rescue phenotype using ex vivo models. Methods Results: Given peptidyl arginine deiminase 4 (PAD4) is essential for formation of NETs, PAD4 knockout mice were used this study. First,...
SUMMARY The effects of propranolol on arterial blood pressure, heart rate, and cardiac rhythm during ventricular arrhythmias initiated by hypercarbia were investigated in thirteen subjects 1 per cent halothane anaesthesia. Propranolol was consistently effective the treatment arrhythmia induced all subjects. successful use suggests that mechanism for produced respiratory acidosis anaesthesia related to beta adrenergic receptors. Blockade these receptors agents decreased markedly sensitization...
Abstract Der Dichlorokobalt(III)‐Komplex des Titelliganden reagiert mit Carbonat‐ oder Hydrogencarbonat‐Ionen zu dem Carbonato‐Co(III)‐tetraamin‐Komplex, A‐cis‐β‐Konfiguration zugeordnet wird.