A5076035220- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Epilepsy research and treatment
- Adolescent and Pediatric Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Neuropharmacology Research
- Coordination Chemistry and Organometallics
- Tryptophan and brain disorders
- Pharmaceutical studies and practices
- Ion channel regulation and function
- Electrolyte and hormonal disorders
- Mental Health and Psychiatry
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Psychosomatic Disorders and Their Treatments
- Family Support in Illness
- Psychiatric care and mental health services
- Stuttering Research and Treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Health and Medical Studies
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
Paracelsus Medizinische Privatuniversität
2016-2024
The University of Texas Southwestern Medical Center
2003-2023
VA Greater Los Angeles Healthcare System
2023
University of California, Los Angeles
2007-2023
Klinikum am Weissenhof
2017-2022
Mental Health Research UK
2021
Centre for Mental Health
2021
Lancaster University
2021
Institute for Health Metrics and Evaluation
2021
Johns Hopkins University
2021
The British Association for Psychopharmacology guidelines specify the scope and target of treatment bipolar disorder. second version, like first, is based explicitly on available evidence presented, previous Clinical Practice guidelines, as recommendations to aid clinical decision making practitioners: they may also serve a source information patients carers. are presented together with more detailed but selective qualitative review evidence. A consensus meeting, involving experts in...
The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence lacking, expert consensus can guide treatment decisions. International Society for Bipolar Disorders (ISBD) convened a task force to seek recommendations on the use antidepressants disorders.An iteratively developed through serial consensus-based revisions using Delphi method. Initial survey items were based systematic review literature. Subsequent surveys included new or...
Article AbstractBackground: Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine treatment of bipolar I disorder in recently depressed or manic patients. Method: 1315 patients (DSM-IV) enrolled the initial open-label phase, 638 were stabilized randomly assigned to 18 months double-blind monotherapy with (N = 280; 50-400 mg/day fixed dose 100-400 flexible dose), lithium 167; serum level 0.8-1.1 mEq/L), placebo 191). The primary endpoint...
Whole-cell and extracellular recording techniques were used to examine local circuit inhibition in the CA1 region of rat hippocampus vitro. Activation, primarily recurrent inhibitory by alvear stimulation, elicited an IPSP pyramidal neurons that was dependent, part, on NMDA receptor activation. Application a tetanizing stimulus alveus evoked long-term potentiation (LTP) intracellularly recorded IPSPs. This LTP also NMDA- dependent more sensitive blockade antagonists 2-...
OBJECTIVE: The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials adjunctive antidepressant treatment bipolar depression. METHOD: One hundred fifty-nine patients with I disorder II participated a total 228 (10-week) randomized bupropion, sertraline, venlafaxine as an adjunct to stabilizer. Patients 87 these entered for up 1 year. Antidepressant response occurrence subthreshold brief (emergence [at least but <7...
Objectives. These guidelines are based on a first edition that was published in 2004, and have been edited updated with the available scientific evidence up to October 2012. Their purpose is supply systematic overview of all pertaining long-term treatment bipolar disorder adults. Methods. Material used for these literature search using various data bases. rigor categorised into six levels (A–F) different grades recommendation ensure practicability were assigned. Results. Maintenance trial...
Objectives. These guidelines are based on a first edition that was published in 2002, and have been edited updated with the available scientific evidence until September 2009. Their purpose is to supply systematic overview of all pertaining treatment acute bipolar depression adults. Methods. The data used for these extracted from MEDLINE EMBASE search, clinical trial database clinicaltrials.gov, recent proceedings key conferences, various national international guidelines. rigor categorised...
Article AbstractObjective: To evaluate the efficacy and tolerability of quetiapine monotherapy versus placebo for treatment mania associated with bipolar disorder. Method: In an international, multicenter, double-blind, parallel-group, 12-week study, patients a DSM-IV diagnosis I disorder (manic episode) were randomly assigned to (flexibly dosed up 800 mg/day), placebo, or lithium. The primary measure was change from baseline in Young Mania Rating Scale (YMRS) score at day 21. Data gathered...
Objectives: To assess the proportion of time spent in mania, depression and euthymia a large cohort bipolar subjects studied longitudinally, to investigate depression/mania ratios patients with I versus II disorder. Methods: Clinician‐adjusted self‐ratings mood were completed daily for one year naturalistically treated outpatients (n = 405) or 102) Ratings analyzed mean euthymic, depressed, manic, hypomanic, cycling, percentages ill compared between two groups. Results: Percentages were:...
OBJECTIVE: The authors compared the efficacy of olanzapine and lithium in prevention mood episode relapse/recurrence. METHOD: Patients with a diagnosis bipolar disorder (manic/mixed), history two or more manic mixed episodes within 6 years, Young Mania Rating Scale total score ≥20 entered study received open-label cotreatment for 6–12 weeks. Those meeting symptomatic remission criteria (Young ≤12; 21-item Hamilton depression scale ≤8) were randomly assigned to 52 weeks double-blind...
These updated guidelines are based on a first edition that was published in 2003, and have been edited with the available scientific evidence until end of 2008. Their purpose is to supply systematic overview all pertaining treatment acute mania adults. The data used for these extracted from MEDLINE EMBASE search, clinical trial database clinicaltrials.gov, recent proceedings key conferences, various national international guidelines. rigor categorised into six levels (A-F). As intended use,...
Article Abstract Objective: We examined the influence of age at onset illness and delay in time to first treatment on morbidity adulthood. Method: 529 adult outpatients with a mean 42 years, who entered our research network from 1996 through 2001 were diagnosed bipolar disorder according DSM-IV criteria, rated prospectively daily basis National Institute Mental Health-Life Chart Method during naturalistic for up 4 years. Results: Fifty percent patients had childhood (< 13 years age) or...
Background Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression. Aims To examine acute effects bupropion, sertraline and venlafaxine as adjuncts to mood stabilisers. Method In a 10-week trial, participants receiving out-patient treatment for disorder (stratified rapid cycling) were randomly treated flexible dose one antidepressants, their respective matching placebos, Results A total 174...
Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to treatment. Despite evidence for the efficacy of multimodal-ity interventions, majority persons affected by this do not achieve sustain full syndromal recovery. It eagerly anticipated that combining datasets across various information sources (e.g., hierarchical "multi-omic" measures, electronic health records), analyzed using advanced computational methods machine learning), will inform future diagnosis...
Article Abstract Background: Clinical factors related to suicide and attempts have been studied much more extensively in unipolar depression compared with bipolar disorder. We investigated demographic course-of-illness variables better understand the incidence potential clinical correlates of serious 648 outpatients Method: Patients I or II disorder (DSM-IV criteria) diagnosed structured interviews were evaluated using self-rated clinician- rated questionnaires assess prior study entry....
Increased discharge activity of mesopontine cholinergic neurons participates in the production electroencephalographic (EEG) arousal; such arousal diminishes as a function duration prior wakefulness or brain hyperthermia. Whole-cell and extracellular recordings brainstem slice show that are under tonic inhibitory control endogenous adenosine, neuromodulator released during metabolism. This tone is mediated postsynaptically by an inwardly rectifying potassium conductance inhibition...
Psychiatric disorders or drug addiction are often regarded as contraindications against the use of interferon alfa (IFN-α) in patients with chronic hepatitis C. Our aim was to obtain prospective data on adherence well efficacy and mental side effects treatment IFN-α different psychiatric risk groups compared controls. In a trial, 81 C (positive virus[HCV] RNA elevated alanine aminotransferase[ALT] level) (n = 16), methadone substitution 21), former controls without history 23) were treated...
Article Abstract Objective: Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed prevalence correlates overweight, obesity, extreme 644 patients. Method: outpatients with DSM-IV disorder Stanley Foundation Bipolar Treatment Outcomes Network were evaluated structured diagnostic interviews clinician- self-administered questionnaires to determine diagnoses, demographic historical illness characteristics, comorbid Axis I...
While guidelines for treating patients with bipolar depression recommend discontinuing antidepressants within 6 months after remission, few studies have assessed the implications of this strategy on risk depressive relapse. This study examined effect antidepressant discontinuation or continuation relapse among subjects successfully treated an acute episode.Eighty-four disorder who achieved remission from a episode addition to ongoing mood stabilizer regimen were followed prospectively 1...
Objective: Modafinil is approved by the U.S. Food and Drug Administration for improving wakefulness in patients with excessive sleepiness associated narcolepsy, obstructive sleep apnea, shift-work disorder. This study was conducted to evaluate efficacy safety of adjunctive modafinil bipolar depression, which often characterized fatigue. Method: Eighty-five depression that inadequately responsive a mood stabilizer or without concomitant antidepressant therapy were randomly assigned receive...