A5050910401- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Autism Spectrum Disorder Research
- Virus-based gene therapy research
Emory University
2013-2022
Emory National Primate Research Center
2007-2019
Oregon National Primate Research Center
2018
Center for Neurosciences
2007-2008
Harvard University
1995-2001
Harvard University Press
1995-2000
Signature Healthcare Brockton Hospital
1994-1999
The University of Texas Medical Branch at Galveston
1991-1994
University of Edinburgh
1989-1991
Whole-cell and extracellular recording techniques were used to examine local circuit inhibition in the CA1 region of rat hippocampus vitro. Activation, primarily recurrent inhibitory by alvear stimulation, elicited an IPSP pyramidal neurons that was dependent, part, on NMDA receptor activation. Application a tetanizing stimulus alveus evoked long-term potentiation (LTP) intracellularly recorded IPSPs. This LTP also NMDA- dependent more sensitive blockade antagonists 2-...
Increased discharge activity of mesopontine cholinergic neurons participates in the production electroencephalographic (EEG) arousal; such arousal diminishes as a function duration prior wakefulness or brain hyperthermia. Whole-cell and extracellular recordings brainstem slice show that are under tonic inhibitory control endogenous adenosine, neuromodulator released during metabolism. This tone is mediated postsynaptically by an inwardly rectifying potassium conductance inhibition...
Whole cell patch-clamp recordings were obtained from projection neurons and interneurons of the rat basolateral amygdala (BLA) to understand local network interactions in morphologically identified their modulation by serotonin. Projection characterized electrophysiologically according intrinsic membrane properties synaptic characteristics. Synaptic activity was dominated spontaneous inhibitory postsynaptic currents (IPSCs) that multiphasic, reached 181 ± 38 pA amplitude, lasted 296 27 mS,...
The amygdala is involved in the associative processes for both appetitive and aversive emotions, its function modulated by stress hormones. neuropeptide corticotrophin releasing factor (CRF) released during has been linked to many stress-related behavioral, autonomic, endocrine responses. In present study, nonanxiety-inducing doses of a potent CRF type 1 2 receptor agonist, urocortin (Ucn), was infused locally into basolateral (BLA) rats. After 5 daily injections Ucn, animals developed...
Mice deficient for the gene encoding α-calcium-calmodulin-dependent kinase II (α-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with specific molecular lesion. The heterozygous mouse exhibited well-circumscribed syndrome of abnormalities, consisting primarily decreased fear response an increase in defensive aggression, absence any measured cognitive deficits. Unlike heterozygote, homozygote displayed abnormal behavior all paradigms tested. At...
1. Intracellular recording techniques were used to characterize synaptic inhibitory postsynaptic potentials (IPSPs) recorded from neurons of the basolateral nucleus amygdala (BLA). Bipolar electrodes positioned in stria terminalis (ST) or lateral (LA) evoke responses at a frequency 0.25 Hz. 2. Two waveforms having IPSP components could be evoked by electrical stimulation either pathway: biphasic, excitatory potential (EPSP), fast-IPSP (f-IPSP) waveform, and multiphasic, EPSP, f-IPSP,...
1. Intracellular current-clamp recordings were made from neurons of the basolateral nucleus amygdala (BLA) rat in vitro slice preparation. Neurons identified morphologically after intracellular injection biocytin, and electrophysiological properties morphological characteristics correlated. 2. Three distinct subtypes identified: Class I pyramidal neurons, stellate II neurons. Each subtype could also be distinguished according to its characteristic properties. 3. typically had perikarya...
In vivo microdialysis was used to analyze the role of dorsal raphe nucleus (DRN) neurons in regulating sleep-waking cycle. Measurements extracellular serotonin (5-HT) were made DRN freely moving adult cats before and during perfusion 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist, artificial CSF. Behavioral state alterations measured by simultaneous polygraphic recordings. During waking CSF probes histologically localized DRN, 5-HT 4 fmol/7.5 micro L...
Corticotrophin-releasing factor (CRF) plays a key role in initiating many of the endocrine, autonomic, and behavioral responses to stress. CRF-containing neurons paraventricular nucleus hypothalamus (PVN) are classically involved regulating endocrine function through activation stress axis. However, CRF is also thought play critical mediating anxiety-like environmental stressors, dysfunction system extra-hypothalamic brain regions, like bed stria terminalis (BNST), has been linked etiology...
Nicotine is reported to increase arousal and attention elevate mood, effects that are most often associated with changes in the function of monoaminergic neuromodulatory systems (Feldman et al., 1997). Recent studies have shown a nicotinic receptor-mediated presynaptic enhancement fast glutamatergic (McGehee 1995;Gray 1996) GABAergic (Léna Changeux, 1997) transmission. However, mechanism on metabotropic-mediated transmission general, particular, less well understood. We examined dorsal raphe...
1. Intracellular current-clamp recordings obtained from neurons of the basolateral nucleus amygdala (BLA) were used to characterize postsynaptic potentials elicited through stimulation stria terminalis (ST) or lateral (LA). The contribution glutamatergic receptor subtypes excitatory (EPSPs) analyzed by use non N-methyl-D-aspartate (non-NMDA) antagonist, 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX), and NMDA (DL)-2-amino-5-phosphonovaleric acid (APV). 2. Basic membrane properties BLA...
Abstract The basolateral amygdala (BLA) is critical for the generation of emotional behavior and formation memory. Understanding neuronal mechanisms that contribute to information processing in BLA will ultimately require knowledge anatomy physiology its constituent neurons. Two major cell classes exist BLA, pyramidal projection neurons nonpyramidal interneurons. Although properties have been studied detail, little known about We used whole‐cell patch clamp recording techniques examine...
The anterolateral group of the bed nucleus stria terminalis (BNST(ALG)) plays a critical role in diverse array behaviors, although little is known physiological properties neurons this region. Using whole cell patch-clamp recordings from rat BNST(ALG) slices vitro, we describe three distinct types. Type I were characterized by presence depolarizing sag response to hyperpolarizing current injection that resembled activation hyperpolarization-activated cation I(h) and regular firing pattern...