A5089555188- Sleep and Wakefulness Research
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Sleep and Work-Related Fatigue
- Obstructive Sleep Apnea Research
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Neuroscience, Education and Cognitive Function
- Ion channel regulation and function
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neural Engineering
- Olfactory and Sensory Function Studies
- Cholinesterase and Neurodegenerative Diseases
Harvard University
2015-2025
VA Boston Healthcare System
2014-2023
Boston VA Research Institute
2018-2021
Versar (United States)
2012
Stonehill College
2011-2012
Beth Israel Deaconess Medical Center
2004
Boston University
2004
Signature Healthcare Brockton Hospital
1997-2002
Stony Brook University
1991-1998
University of Helsinki
1997
Both subjective and electroencephalographic arousal diminish as a function of the duration prior wakefulness. Data reported here suggest that major criteria for neural sleep factor mediating somnogenic effects prolonged wakefulness are satisfied by adenosine, neuromodulator whose extracellular concentration increases with brain metabolism which, in vitro, inhibits basal forebrain cholinergic neurons. In vivo microdialysis measurements freely behaving cats showed adenosine concentrations...
Significance When we are awake, purposeful thinking and behavior require the synchronization of brain cells involved in different aspects same task. Cerebral cortex electrical oscillations gamma (30–80 Hz) range particularly important such synchronization. In this report identify a particular subcortical cell type which has increased activity during waking is activating cerebral generating oscillations, enabling active cortical processing. Abnormalities mechanisms controlling disordered...
Although mammals of different species have sleep patterns, brief sleep-wake transitions commonly are observed across and appear to occur randomly throughout the sleeping period. The dynamical patterns functions these awakenings from not well understood, they often viewed as disruptions (random or pathologic) process. In this article, we hypothesize that may reflect aspects endogenous control mechanism thus exhibit certain robust species. We analyze recordings mice, rats, cats, humans,...
Abstract: Extracellular levels of endogenous serotonin (5‐HT) and its major metabolite, 5‐hydroxyindoleacetic acid (5‐HIAA), were measured in the caudate‐putamen anesthetized awake rats using intracerebral microdialysis coupled to HPLC with fluorimetric detection. A dialysis probe (of loop type) was perfused Ringer solution at 2 μl/min, samples collected every 30 or 60 min. Basal indole followed for up 4 days both intact 5,7‐dihydroxytryptamine (5,7‐DHT) lesioned animals. Immediately after...
Abstract Sleep fragmentation, a symptom in many clinical disorders, leads to cognitive impairments. To investigate the mechanisms by which sleep fragmentation results memory impairments, rats were awakened once every 2 min via 30 s of slow movement on an automated treadmill. Within 1 h this interruption (SI) schedule, began 90‐s periods without treadmill movement. Total non‐rapid eye (NREM) time did not change over 24 SI, although there was significant decline rapid (REM) and corresponding...
Cholinergic neurons of the mesopontine nuclei are strongly implicated in behavioral state regulation. One population cholinergic zone laterodorsal tegmentum and pedunculopontine nuclei, referred to as rapid eye movement (REM)-on neurons, shows preferential discharge activity during REM sleep, extensive data indicate a key role production this state. Another neuronal group present same Wake/REM-on both wakefulness sleep is electroencephalographic activation these states. To test hypothesis...
Improving our understanding of sleep physiology and pathophysiology is an important goal for both medical general wellness reasons. Although the gold standard assessing remains laboratory polysomnogram, there increasing interest in portable monitoring devices that provide opportunity real-world environments such as home. Portable allow repeated measurements, evaluation temporal patterns, self-experimentation. We review recent developments designed to monitor sleep-wake activity, well...