A5016717006- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Ion channel regulation and function
- Stress Responses and Cortisol
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
- Parkinson's Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Amino Acid Enzymes and Metabolism
- Psychedelics and Drug Studies
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Pharmacological Receptor Mechanisms and Effects
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Electroconvulsive Therapy Studies
- Diet and metabolism studies
University of Oxford
2016-2025
University of Kansas
2025
Berenson Allen Center for Noninvasive Brain Stimulation
2020
Beth Israel Deaconess Medical Center
2020
Queen Mary University of London
2016
Mansfield University
2001-2012
Maastricht University
2010
Mansfield Community Hospital
2009
Indiana University – Purdue University Indianapolis
2000-2005
Fundación Juan March
2005
Abstract: By using a new technique, intracerebral dialysis, in combination with high performance liquid chromatography and electrochemical detection, it was possible to recover measure endogenous extracellular dopamine, together its metabolites dihydroxyphenylacetic acid (DOPAC) homovanillic (HVA) from the striatum nucleus accumbens of anaesthetized or freely moving rats. In addition, measurements 5‐hydroxyindoleacetic acid, ascorbic uric were made. Basal concentrations dopamine DOPAC...
An intracerebral perfusion method, brain microdialysis, was used to assess changes of 5‐hydroxytryptamine (5‐HT) release in the ventral hippocampus chloral hydrate‐anaesthetized rat response systemic administration a variety 5‐HT 1 receptor agonists. A stable output reliably detectable endogenous measured dialysates collected from with reuptake inhibitor, citalopram, present medium. Under these conditions putative 1A agonist 8‐hydroxy‐2‐(di‐n‐propylamino)tetralin (8‐OH‐DPAT) caused...
The acute inhibitory effect of selective 5‐hydroxytryptamine (serotonin) reuptake inhibitors (SSRIs) on 5‐HT neuronal activity may offset their ability to increase synaptic in the forebrain. 2Here, we determined effects SSRI, paroxetine, and a novel 1A receptor antagonist, WAY 100635, cell firing dorsal raphe nucleus (DRN), extracellular both DRN frontal cortex (FCx). Extracellular electrophysiological recording brain microdialysis were used parallel experiments, anaesthetized rats....
Abstract Intracerebral dialysis was used with a specifically designed HPLC electrochemical detection assay to monitor extracellular levels of endogenous 3,4‐dihydroxyphenylethylamine (dopamine, DA) and its major metabolites, dihydroxyphenylacetic acid (DOPAC) homovanillic (HVA), in brain regions the halo‐thane‐anesthetized rat. Significant amounts DA, DOPAC, HVA were detected control perfusates collected from striatum n. accumbens whereas medial prefrontal cortex showed lower monoamine...
Abstract: The effect of manipulating the activity central 5‐hydroxytryptamine (5‐HT) neurones on extracellular 5‐HT in ventral hippocampus chloral hydrate‐anaesthetized rat was studied using brain perfusion method, microdialysis. Basal levels dialysates were close to detection limits our assay HPLC with electrochemical detection. However, addition selective reuptake inhibitor citalopram (10 −6 M ) medium produced readily measurable amounts dialysate 5‐HT. Citalopram, therefore, used...
Bilateral, high-frequency stimulation (HFS) of the subthalamic nucleus (STN) is surgical therapy choice for movement disability in advanced Parkinson's disease (PD), but this procedure evokes debilitating psychiatric effects, including depressed mood, unknown neural origin. Here, we report unexpected finding that HFS STN inhibits midbrain 5-hydroxytryptamine (5-HT) neurons to evoke depression-related behavioral changes. We found bilateral consistently inhibited (40-50%) firing rate 5-HT...
1. We examined the involvement of frontal cortex in 5-HT2A receptor-induced inhibition 5-HT neurones dorsal raphe nucleus (DRN) anaesthetized rat using single-unit recordings complemented by Fos-immunocytochemistry. 2. Both transection as well ablation medial region prefrontal (mPFC) significantly attenuated induced systemic administration 5-HT1A receptor agonist, 8-OH-DPAT (0.5-16 microg kg(-1), i.v.). In comparison, response to was not altered parietal cortex. The inhibitory effect...
Recent neurochemical studies of the properties 5-hydroxytryptamine (5-HT) pathways arising from dorsal raphe nucleus (DRN) and median (MRN) have measured extracellular 5-HT in brain regions with reported preferential DRN or MRN inputs. Here, we tested whether electrical stimulation releases rat forebrain a pattern that fits distribution DRN/MRN pathways. The effect on (5 Hz, 300 microA, 20 min) DRN, then MRN, was determined six anaesthetised rat. Stimulation evoked short-lasting but...
The serotonin (5-HT) system and the amygdala are key regulators of emotional behavior. Several lines evidence suggest that 5-HT transmission in is implicated susceptibility drug treatment mood disorders. Therefore, elucidating physiological mechanisms through which midbrain neurons modulate circuits could be pivotal understanding regulation health disease. To shed light on these mechanisms, we performed patch-clamp recordings from basal (BA) brain slices mice with channelrhodopsin...