A5061537286- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Hypothalamic control of reproductive hormones
- Sexual function and dysfunction studies
- Neurological disorders and treatments
- Neural dynamics and brain function
- Bipolar Disorder and Treatment
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Regulation of Appetite and Obesity
- Parkinson's Disease Mechanisms and Treatments
- Evolutionary Psychology and Human Behavior
- Electroconvulsive Therapy Studies
- Birth, Development, and Health
- Sexuality, Behavior, and Technology
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- Treatment of Major Depression
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
Boehringer Ingelheim (Germany)
2010-2023
Boehringer Ingelheim (Australia)
2021-2022
Pfizer (United Kingdom)
2006-2018
Lothian Sexual Health
2018
Pfizer (United States)
2010
University of Oxford
2004-2007
National Institutes of Health
2000-2004
Mansfield University
2003
National Institute of Neurological Disorders and Stroke
2000-2002
Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i were observed in the striatum of both control 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP)-treated monkeys; cell counts, however, 3.5-fold higher MPTP-lesioned monkeys. To establish nature cells, sections double-labeled with antibodies dopamine transporter...
Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a role in depression pathophysiology. Studies comparing TRYCATs levels depressed subjects and controls provided mixed findings. We examined association of with 1) presence Major Depressive Disorder (MDD), 2) depressive symptom profiles 3) inflammatory markers.The sample from Netherlands Study Depression Anxiety included participants current (n = 1100) or remitted 753) MDD DSM-IV diagnosis healthy 642). Plasma...
Abstract Recent electrophysiological studies have discovered evidence of heterogeneity 5‐hydroxytryptamine (5‐HT) neurons in the mesencephalic raphe nuclei. Of particular interest is a subpopulation putative 5‐HT that display many properties presumed 5‐HT‐containing (regular and slow firing single spikes with broad waveform) but fire short, stereotyped bursts. In present study we investigated chemical identity these rats utilizing vivo juxtacellular labelling methods. ten dorsal nucleus...
Systemic administration of phenethylamine‐derived, 5‐hydroxytryptamine 2 (5‐HT ) receptor agonists inhibits the firing midbrain 5‐HT neurones, but receptors involved are poorly defined, and contribution peripheral mechanisms is uncertain. This study addresses these issues using extracellular recordings neurones in dorsal raphe nucleus anaesthetised rats. The DOI ((±)‐2,5‐dimethoxy‐4‐iodoamphetamine hydrochloride) DOB ((±)‐2,5‐dimethoxy‐4‐bromoamphetamine hydrobromide), caused a dose‐related...
Objectives Kynurenine, kynurenic and quinolinic acid are important metabolites in tryptophan metabolism. Due to an involvement glutamatergic neurotransmission immune response, previous studies have investigated this pathway mental disorders such as major depressive disorder (MDD), bipolar (BD) or schizophrenia (SCZ). Tryptophan kynurenine been shown be decreased across disorders, hinting at the missing link how inflammation causes neurotoxicity psychiatric symptoms. The main aim of our study...
The brain is a central hub for integration of internal and external conditions and, thus, regulator the stress response. Glucocorticoids are essential communicators this Aberrations in glucocorticoid signaling common symptom patients with psychiatric disorders. gene FKBP5 encodes chaperone protein that functionally inhibits contributes to regulation stress. In context childhood trauma, differential expression has been found compared controls. These variations levels were reported be...
Multisecond oscillations in firing rate with periods the range of 2–60 s (mean, 20–35 s) are present 50–90% spike trains from basal ganglia neurons recorded locally anesthetized, immobilized rats. To determine whether these periodic associated similar periodicities cortical activity, transcortical electroencephalographic (EEG) activity was conjunction single- or dual-unit neuronal subthalamic nucleus (STN) globus pallidus (GP), and data were analyzed spectral wavelet analyses. rates 31% STN...
A growing body of research has indicated a role for B vitamins in depression, with some previous studies suggesting that vitamin status patients depression can impact on antidepressant response. Here we aimed to investigate plasma concentrations medicated ( n = 94) compared age- and sex-matched healthy controls 57), after electroconvulsive therapy (ECT) real-world clinical setting. Our results show nicotinamide (vitamin B3), N1-methylnicotinamide B3 metabolite), pyridoxal 5′-phosphate...
Abstract The cumulative load of genetic predisposition, early life adversity (ELA) and lifestyle shapes the prevalence psychiatric disorders. Single nucleotide polymorphisms (SNPs) in human FKBP5 gene were shown to modulate disease risk. To enable investigation disease-related SNPs behaviourally relevant context, we generated humanised mouse lines carrying either risk (AT) or resiliency (CG) allele rs1360780 locus exposed litters these mice maternal separation. Behavioural physiological...
Clinical and preclinical data indicate that the subthalamic nucleus (STN) plays a critical role in mediating hyper- hypoactive behavioral states associated with increases decreases dopamine receptor stimulation basal ganglia. The present study investigates effects of on slow multisecond oscillations firing rates STN neurons. Extracellular, single-unit recordings were performed locally anesthetized immobilized rats which either intact or had received unilateral 6-OHDA lesions medial forebrain...