A5003117406- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Psychosomatic Disorders and Their Treatments
- Musculoskeletal pain and rehabilitation
- Neonatal and fetal brain pathology
- Facial Nerve Paralysis Treatment and Research
- Cardiac, Anesthesia and Surgical Outcomes
- EEG and Brain-Computer Interfaces
- Mindfulness and Compassion Interventions
- Urban Green Space and Health
- Anesthesia and Sedative Agents
- Neurofibromatosis and Schwannoma Cases
Royal College of Surgeons in Ireland
2020-2025
Universitätsklinikum Aachen
2023
St. Vincent's University Hospital
2021-2023
RWTH Aachen University
2023
Beaumont Hospital
2023
University College Dublin
2018-2022
Trinity College Dublin
2018-2022
Trinity College
2021
St Richard's Hospital
2020
St. James's Hospital
1998
Abstract Adults with attention‐deficit/hyperactivity disorder (ADHD) have been described as having altered resting‐state electroencephalographic (EEG) spectral power and theta/beta ratio (TBR). However, a recent review (Pulini et al. 2018) identified methodological errors in neuroimaging, including EEG, ADHD classification studies. Therefore, the specific EEG neuromarkers of adult remain to be identified, do characteristics that mediate between genes behaviour (mediational endophenotypes)....
The role of the amygdala in experience emotional states and stress is well established. Connections from to hypothalamus activate hypothalamic–pituitaryadrenal (HPA) axis cortisol response. Previous studies have failed find consistent whole volume changes Major Depressive Disorder (MDD), but differences may exist at smaller substructural level nuclei. High-resolution T1 T2-weighted-fluid-attenuated inversion recovery MRIs were compared between 80 patients with MDD 83 healthy controls (HC)...
This study investigated the effects of group walking in forests for people with significant mental ill-health including depression, bipolar and anxiety disorders based on a pilot program Ireland. The consisted activities forest setting approximately 2 hr duration weekly, 13 weeks, which included roughly 10 min gentle warming-up exercises, 1–1.5 walks, followed by 30 refreshments/socializing sites. Fifteen participants were assessed. results indicated improvements mood, measured Positive...
Abstract Early life adversity, defined as exposure to stressful events during childhood, is a significant risk factor for the development of psychiatric disorders. Diffusion tensor imaging studies employing tract-based spatial statistics have shown microstructural abnormalities in white matter among individuals exposed early adversity; however, robust conclusions are yet be drawn. This systematic review synthesizes findings previous identify alterations adult brains papers with...
Commentary on: Roddy DW, Farrell C, Doolin K, Roman E, Tozzi L, Frodl T, O'Keane V, O'Hanlon E. The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation Depression. Biol Psychiatry. 2019 Mar 15;85(6):487-497. doi: 10.1016/j.biopsych.2018.08.021. Epub 2018 Sep 6. PubMed PMID: 30528746. hippocampus is a key cognitive hub implicated major depressive disorder. However, disorder neuroimaging studies have used inconsistent anatomical hippocampal...
Aims Smaller hippocampal volumes are among the most consistently reported neuroimaging findings in schizophrenia. However, little is known about people who report psychotic experiences. This study investigated differences volume between young without formal diagnoses experiences (PEs) and those do not such also if any persisted over two years. Methods A nested case-control of 25 adolescents (mean age 13.5 years) with PEs matched controls 13.36 were drawn from a sample 100 local...
The Stria Medullaris Thalami is a discrete white matter tract that directly connects frontolimbic areas to the habenula, allowing forebrain influence midbrain monoaminergic output. Habenular dysfunction has been shown in various neuropsychiatric conditions. However, there exists paucity of research into habenula's principal afferent tract, stria medullaris. Diffusion-weighted tractography may provide insights properties medullaris vivo, opening up investigation this conditions monoamine...
Introduction Chronic pain is defined as lasting longer than 3 months. This often causes persistent emotional distress and functional disability that refractory to conventional treatments. Emerging evidence suggests oral Ketamine therapy may have a specific role in managing treatment-resistant chronic pain. study aimed assess the effectiveness of ketamine within tertiary management clinic. Methods was clinic-based retrospective descriptive 79 patients with broad range diagnoses treated over...
Magnetic resonance spectroscopy (MRS) is a non-invasive analytical technique that investigates the presence and concentrations of brain metabolites. In context major depressive disorder (MDD), MRS has revealed regional biochemical changes in GABA, glutamate, choline across different compartments. Technical methodological advances data acquisition, particular proton-based 1H-MRS, have resulted significant increase incidence reports utilizing for psychiatric research diagnosis. The most recent...
Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses associated with connectivity white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) adolescents reported PEs matched controls, we examined cingulum tract along its length rather than usually single indivisible structure. Complex regional differences metrics were found bundle at key loci following Bonferroni...
Abstract A berrant connectivity in the cerebellum has been found psychotic conditions such as schizophrenia corresponding with cognitive and motor deficits these conditions. Diffusion differences superior cerebellar peduncles, white matter connecting circuitry to rest of brain, have also high-risk states. However, diffusivity peduncles individuals sub-threshold experiences (PEs) but not reaching threshold for a definitive diagnosis remains unstudied. This study investigates adolescents PEs...