A5100631067- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Metabolism and Genetic Disorders
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Schizophrenia research and treatment
- Adolescent and Pediatric Healthcare
- Receptor Mechanisms and Signaling
- RNA regulation and disease
- Diet and metabolism studies
- Ion channel regulation and function
- Electroconvulsive Therapy Studies
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Treatments and Studies
- RNA and protein synthesis mechanisms
- Neuropeptides and Animal Physiology
- Advanced Neuroimaging Techniques and Applications
RIKEN Center for Brain Science
2016-2025
Juntendo University
1998-2025
Juntendo University Hospital
2021-2024
Kanazawa University
2021-2024
Kumamoto University
2023
Murata (United States)
2023
RIKEN
2004-2023
Hokkaido University Hospital
2023
Kubota (Japan)
2023
Fujita Health University
2004-2022
The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence lacking, expert consensus can guide treatment decisions. International Society for Bipolar Disorders (ISBD) convened a task force to seek recommendations on the use antidepressants disorders.An iteratively developed through serial consensus-based revisions using Delphi method. Initial survey items were based systematic review literature. Subsequent surveys included new or...
The legume Lotus japonicus has been widely used as a model system to investigate the genetic background of legume-specific phenomena such symbiotic nitrogen fixation.Here, we report structural features L. genome.The 315.1-Mb sequences determined in this and previous studies correspond 67% genome (472 Mb), are likely cover 91.3% gene space.Linkage mapping anchored 130-Mb onto six linkage groups.A total 10 951 complete 19 848 partial structures protein-encoding genes were assigned...
Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ). We performed large-scale DNA microarray analysis postmortem brains patients with BD or SZ, examined expression patterns mitochondria-related genes. found a global down-regulation genes, such as those encoding respiratory chain components, in SZ samples, even after effect sample pH was controlled. However, this likely due to effects medication....
Substantial evidence suggests that chromosomal abnormalities contribute to the risk of autism. The duplication human chromosome 15q11-13 is known be most frequent cytogenetic abnormality in We have modeled this genetic change mice by using engineering generate a 6.3 Mb conserved linkage group on mouse 7. Mice with paternal display poor social interaction, behavioral inflexibility, abnormal ultrasonic vocalizations, and correlates anxiety. An increased MBII52 snoRNA within duplicated region,...
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In present GWAS (Phase I/II), which included 2964 61 887 control subjects from Japanese population, we detected a novel locus at 11q12.2 (rs28456, P=6.4 × 10−9), region known contain regulatory genes plasma lipid levels (FADS1/2/3). A subsequent meta-analysis...
Abstract Detailed analyses of transcriptome have revealed complexity in regulation alternative splicing (AS). These AS events often undergo modulation by genetic variants. Here we analyse RNA-sequencing data prefrontal cortex from 206 individuals combination with their genotypes and identify cis -acting quantitative trait loci (sQTLs) throughout the genome. sQTLs are enriched among exonic H3K4me3-marked regions. Moreover, observe significant enrichment disease-associated identified GWAS,...
Highlights•Exome sequencing of Japanese ASD trios supports "de novo paradigm"•Integrative analyses were conducted by combining with published DNM data•Integrative confirm and extend ASD-related molecular brain networks•Integrative identify 61 significant genes as well drug candidatesSummaryRecent studies have established important roles de mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs 262 probands origin the paradigm" ASDs across ethnicities. Based on this...
Downregulation of oligodendrocyte-related genes, referred to as oligodendrocyte dysfunction, in schizophrenia has been revealed by DNA microarray studies. Because oligodendrocyte-specific transcription factors regulate the differentiation oligodendrocytes, genes encoding them are prime candidates for dysfunction schizophrenia. We found that cytosine-guanine dinucleotide (CpG) island sex-determining region Y-box containing gene 10 (SOX10), an factor, tended be highly methylated brains...
Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences function as well susceptibility various diseases such Parkinson disease, Alzheimer bipolar disorder, cancer. However, it unclear whether how mtDNA polymorphisms affect intracellular function, calcium signaling or pH regulation. Here we searched for that have functional significance using transmitochondrial hybrid cells (cybrids) carrying ratiometric Pericam (RP), a...