Louise Frisén
A5103009328- Bipolar Disorder and Treatment
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Hormonal and reproductive studies
- Adolescent and Pediatric Healthcare
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Urinary and Genital Oncology Studies
- Metabolism and Genetic Disorders
- LGBTQ Health, Identity, and Policy
- Growth Hormone and Insulin-like Growth Factors
- Congenital Anomalies and Fetal Surgery
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Gender, Feminism, and Media
- Adrenal Hormones and Disorders
- Gender Roles and Identity Studies
- Congenital Diaphragmatic Hernia Studies
- Hormonal Regulation and Hypertension
- Obsessive-Compulsive Spectrum Disorders
- Urologic and reproductive health conditions
- Reproductive Health and Technologies
- Sexuality, Behavior, and Technology
Karolinska Institutet
2015-2024
Karolinska University Hospital
2012-2024
Stockholm Health Care Services
2019-2023
Genomics (United Kingdom)
2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2020
The Centers
2019
Stockholm County Council
2014-2019
RELX Group (Netherlands)
2017
American Academy of Child and Adolescent Psychiatry
2017
BioArctic Neuroscience (Sweden)
2014-2017
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
Gender-atypical behavior has been described in young girls as well women with congenital adrenal hyperplasia (CAH) due to a CYP21A2 deficiency.The aim of the study was assess health-related, psychosexual, and psychosocial parameters correlate results genotype.Sixty-two Swedish CAH age-matched controls completed 120-item questionnaire validated quality life instrument [psychological general well-being (PGWB) formula] identify psychosexual parameters. The patients were divided into four...
To assess the risk of psychiatric disorders and suicide attempts in children with type 1 diabetes their healthy siblings.We performed a population-based case-cohort study individuals born Sweden between 1973 2009. Children (n = 17,122) siblings 18,847) were identified followed until 18th birthday. Their was compared that matched control subjects.The morbidity general population tripled within 6 months after onset (hazard ratio [HR] 3.0 [95% CI 2.7-3.4]) doubled total observation period (HR...
Context:Congenital adrenal hyperplasia (CAH) is lethal in its most severe forms if not treated with glucocorticoids. However, glucocorticoids may increase the risk of cardiovascular and metabolic morbidity.
Context: In congenital adrenal hyperplasia (CAH) caused by different mutations, feminizing surgery is mostly performed in childhood, and many patients are lost to follow-up.
Low pregnancy rate has been reported in women with congenital adrenal hyperplasia (CAH) and little information on children is known.In a Swedish study, 62 adult CAH, aged 18-63 years, age-matched controls were followed-up. Medical records, including those concerning pregnancies deliveries, examined the 21-hydroxylase genotype of patients was noted. All answered questionnaire sexual reproductive health children.Pregnancy delivery rates significantly lower CAH (P < 0.001, P 0.0056,...
Context: Reports on mortality in patients with congenital adrenal hyperplasia (CAH) are lacking. Objective: This study sought to and causes of death CAH. Design, Setting, Participants: We studied CAH (21-hydroxylase deficiency, n = 588; CYP21A2 mutations known, &gt;80%), compared them controls (n 58 800). Data were derived through linkage national population-based registers. Main Outcome Measures: Mortality death. Results: Mean age was 41.2 ± 26.9 years 47.7 27.7 (P &lt; .001). Among...
Females with congenital adrenal hyperplasia (CAH) due to a CYP21A2 deficiency are exposed androgens during fetal development, resulting in virilization of the external genitalia. Little is known about how these women feel that disease has affected their lives regarding surgery and psychosexual adaptation.Our objective was investigate correlation between surgical results, self-perceived severity disease, satisfaction sexual life relate results genotype.Sixty-two Swedish CAH age-matched...
We studied the incidence of hypospadias in Sweden during a 40-year period to determine if changes were associated with known risk factors.We analyzed prospective data from nationwide health care and demographic registers collected for all males (1,948,591 total) born between 1973 2009. The per 1,000 live-born boys was calculated as number cases divided by total births yearly. association factors estimated using logistic regression, expressed odds ratios.The diagnosed approximately 4.5 until...
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed ASD during 1973-2009, their 96,557 non-ASD relatives. ASD, without comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related a doubled risk problems. The the highest ADHD. Further, risks were increased full...
Congenital adrenal hyperplasia (CAH), CYP21A2 deficiency, results in cortisol and aldosterone deficiency increased production of androgens, with a good genotype phenotype correlation.The objective the investigation was to study psychosocial outcomes relation clinical severity, genotype, men women.This an epidemiological matched case control design.The setting all known CAH patients Sweden.Five hundred eighty-eight patients, more than 80% severity CAH, 100 controls per patient for sex, year,...
Purpose: To explore whether the increase observed in referrals to child and adolescent gender identity services (GIDSs) has been similar four Nordic countries UK.Materials methods: Numbers of per year 2011–2017 were obtained from all GIDS Denmark, Finland, Norway, Sweden UK related population aged <18.Results: A pattern referral rates was across countries, resulting comparable adjusted 2017. In children, male:female birth sex ratio even; adolescents, a preponderance females (birth sex)...
ABSTRACT Bipolar disorder is a highly heritable psychiatric that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases 31,358 controls European descent, with follow-up analysis 822 sentinel variants at loci P<1×10 -4 in an independent sample 9,412 137,760 controls. In combined analysis, 30 reached significant evidence for association, which 20 were novel. These contain genes encoding ion channels neurotransmitter...
Inflammatory bowel disease (IBD) has been associated with psychiatric morbidity in adults, although previous studies have not accounted for familial confounding. In children, IBD an even more severe course, but the association between childhood-onset and remains unclear.To examine risk of individuals IBD, controlling potential confounding shared siblings.A population-based cohort study was conducted using data from Swedish national health care population registers all children younger than...
ABSTRACT Objective The aim of the study was to evaluate psychiatric symptoms among 1022 persons with various disorders sex development (DSDs). Methods a European multicenter cross-sectional clinical evaluation in six countries. mean (SD) age participants 32.1 (13.4) years. cohort consisted 325 individuals Turner syndrome, 219 Klinefelter syndrome (KS), female XY-DSD conditions (107 and 67 without androgenization), 87 male conditions, 221 congenital adrenal hyperplasia. Hospital Anxiety...