Christine Fraser
A5105407362- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetics and Neurodevelopmental Disorders
- Respiratory Support and Mechanisms
- Schizophrenia research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Genomic variations and chromosomal abnormalities
- Adolescent and Pediatric Healthcare
- Neuroscience of respiration and sleep
- Electroconvulsive Therapy Studies
- Pregnancy and Medication Impact
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Child and Adolescent Psychosocial and Emotional Development
- Heat shock proteins research
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
Cardiff University
2010-2020
Lakewood Regional Medical Center
2010-2020
Centre for Mental Health
2019-2020
St. Paul's Hospital
2020
University of British Columbia
2020
University of California, Los Angeles
2020
Pulmonary Associates
2020
KU Leuven
2020
Cardiovascular Medical Group
2020
University of California, San Francisco
2020
Molecular genetic analysis offers opportunities to advance our understanding of the nosological relationship between psychiatric diagnostic categories in general, and mood psychotic disorders particular. Strong evidence (P=7.0 × 10−7) association at polymorphism rs1006737 (within CACNA1C, gene encoding α-1C subunit L-type voltage-gated calcium channel) with risk bipolar disorder (BD) has recently been reported a meta-analysis three genome-wide studies BD, including BD sample (N=1868) studied...
Abstract Borderline personality disorder (BOR) is determined by environmental and genetic factors, characterized affective instability impulsivity, diagnostic symptoms also observed in manic phases of bipolar (BIP). Up to 20% BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) BOR, performed one largest BOR patient samples worldwide. The focus our analysis was (i) detect genes gene sets involved (ii) investigate overlap...
Background Individuals with a mental health disorder appear to be at increased risk of medical illness. Aims To examine rates illnesses in patients bipolar ( n = 1720) and the clinical course illness according lifetime burden. Method Participants recruited within UK were asked about occurrence 20 illnesses, interviewed using Schedules for Clinical Assessment Neuropsychiatry (SCAN) diagnosed DSM-IV criteria. Results We found significantly several our sample. A high burden was associated...
ABSTRACT Bipolar disorder is a highly heritable psychiatric that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases 31,358 controls European descent, with follow-up analysis 822 sentinel variants at loci P<1×10 -4 in an independent sample 9,412 137,760 controls. In combined analysis, 30 reached significant evidence for association, which 20 were novel. These contain genes encoding ion channels neurotransmitter...
It is commonly -- but wrongly assumed that there are no important differences between the clinical presentations of major depressive disorder and bipolar depression. Here we compare course variables symptom profiles in a large sample individuals with (n=593) (n=443). Clinical characteristics associated included presence psychosis, diurnal mood variation hypersomnia during episodes, greater number shorter episodes. Such features should alert clinician to possible course. This because optimal...
Background Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many these heritable, it would be useful know whether any the various diagnostic categories in current use identify cases that particularly helpful for biological–genetic research. Aims To genome-wide genetic association data explore relative utility seven different operational relevant bipolar illness within a large UK case–control disorder sample. Method We analysed our previously...
Background Pregnancy and childbirth are a period of high risk for women with bipolar disorder involve difficult decisions particularly about continuing or stopping medications. Aims To explore what clinical predictors may help to individualise the perinatal recurrence in disorder. Method Information was gathered retrospectively by semi-structured interview, questionnaires case-note review from 887 who have had children. Clinical were selected using backwards stepwise logistic regression,...
Objectives: Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects lifetime clinical characteristics. We here examine this possibility a large, well‐characterized sample patients with I disorder. Methods: assessed (N = 553) recruited as part our ongoing studies affective disorders. Lifetime characteristics were compared who had depressive first (n 343) and manic 210). Results: Several features differed between according to the...
Abstract Multiplex families with a high prevalence of psychiatric disorder are often examined to identify rare genetic variants large effect sizes. In the present study, we analysed whether risk for bipolar (BD) in BD multiplex is influenced by common variants. Furthermore, investigated this conferred mainly BD-specific or also associated susceptibility schizophrenia major depression. total, 395 individuals from 33 Andalusian (166 BD, 78 depressive disorder, 151 unaffected) as well 438...
Central airway nitric oxide flux (J'(awNO)) and peripheral airway/alveolar concentration (C(ANO)) during asthma exacerbation has not been investigated after correction for axial NO back-diffusion.After measuring exhaled (fraction of (F(E)NO); ppb) at 50, 100, 150 200 ml/s, J'(awNO) (nl/s) C(ANO) (ppb) were calculated using the two-compartment model corrected back-diffusion. Fifteen (8 males), non-smoking, patients with moderate-to-severe treated (inhaled corticosteroid (ICS) inhaled...