A5073613092- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital heart defects research
- Suicide and Self-Harm Studies
- RNA modifications and cancer
- Family and Disability Support Research
- Bipolar Disorder and Treatment
- LGBTQ Health, Identity, and Policy
- Ubiquitin and proteasome pathways
- Genetic Syndromes and Imprinting
- Genetic Associations and Epidemiology
- Child Nutrition and Feeding Issues
- Sexuality, Behavior, and Technology
- Genomic variations and chromosomal abnormalities
- Attachment and Relationship Dynamics
- Adolescent and Pediatric Healthcare
- Gender, Feminism, and Media
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Health and Lifestyle Studies
- Cannabis and Cannabinoid Research
- Child Development and Digital Technology
- Mental Health Treatment and Access
Instituto de Investigación Biomédica de Málaga
2014-2024
University of Córdoba
2024
Universidad de Málaga
2001-2023
Hospital Regional Universitario de Málaga
2014-2020
Laboratoire des Matériaux Avancés
2017
Fundación INTRAS
2011
Hospital Doctor José Molina Orosa
2011
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
2006
Universidad de Sevilla
1995-2002
Medicines Evaluation Board
2002
Lack of fragile X mental retardation protein (FMRP) causes syndrome, a common form inherited retardation. FMRP is an RNA binding thought to be involved in translation efficiency and/or trafficking certain mRNAs. Recently, subset mRNAs which binds with high affinity has been identified. These FMRP-associated contain intramolecular G-quartet structure. In neurons, dendritic are local synthesis proteins response synaptic activity, and this represents mechanism for plasticity. To determine the...
Polymorphic variations in the serotonin transporter gene (5-HTT) moderate depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction brain availability, thus polymorphic 5-HTT may play similar role post-partum period.To study mood changes after delivery.One thousand, eight hundred and four depression-free Spanish women were studied post-partum. We evaluated depressive symptoms at 2-3 days, 8 weeks 32 used diagnostic interview to confirm major depression for...
Abstract A fundamental difficulty in human genetics research is the identification of spectrum genetic variants that contribute to susceptibility common/complex disorders. We tested here hypothesis functional may confer several related common analyzed five main psychiatric diagnostic categories (substance‐abuse, anxiety, eating, psychotic, and mood disorders) two different control groups, representing a total 3,214 samples, for 748 promoter non‐synonymous single nucleotide polymorphisms...
Abstract Previous reports and meta‐analyses have yielded inconclusive results as to whether the s/s genotype at 5‐HTTLPR serotonin transporter polymorphism confers increased risk for depression. We tested association between depression in a large cohort (n = 737) of Spanish primary care consecutive attendees participating European study on predictors (PREDICT study). Participants were administered Composite International Diagnostic Interview (CIDI) subscale allowing diagnoses using ICD‐10...
Abstract Fragile X syndrome is the most common form of inherited mental retardation in humans. It originates from loss expression 1 (FMR1) gene, which results absence protein. However, biochemical mechanisms involved pathological phenotype are mostly unknown. The availability FMR1‐knockout mouse model offers an excellent system to study alterations related brain abnormalities syndrome. We show for first time that brains Fmr1‐knockout mice, a validated syndrome, display higher levels reactive...
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations the Forkhead Box P2 (FOXP2) gene lead to severe spoken disorder. Recently, several studies have pinpointed involvement variants Contactin-Associated Protein-Like 2 (CNTNAP2) gene, whose transcription regulated by product FOXP2, disorders characterized impairments such as autism, specific impairment (SLI), and selective mutism (SM). In present study, FOXP2 CNTNAP2 genes were analyzed through...
Abstract Background Variables such as the mother's personality, social support, coping strategies and stressful events have been described risk factors for postpartum depression. Structural Equation Modelling (SEM) analysis was used to examine whether neuroticism, perceived life events, are associated with depressive symptoms at 8th 32nd weeks. Methods A total of 1626 pregnant women participated in a longitudinal study. Different evaluations were performed 8 32 weeks after delivery. Several...
Abstract Multiplex families with a high prevalence of psychiatric disorder are often examined to identify rare genetic variants large effect sizes. In the present study, we analysed whether risk for bipolar (BD) in BD multiplex is influenced by common variants. Furthermore, investigated this conferred mainly BD-specific or also associated susceptibility schizophrenia major depression. total, 395 individuals from 33 Andalusian (166 BD, 78 depressive disorder, 151 unaffected) as well 438...
The two major subtypes of bipolar disorder (BD), BD-I and BD-II, are distinguished based on the presence manic or hypomanic episodes. Historically, BD-II was perceived as a less severe form BD-I. Recent research has challenged this concept severity continuum. Studies in large samples unrelated patients have described clinical genetic differences between subtypes. Besides an increased schizophrenia polygenic risk load BD-I, these studies also observed depression patients. present study...
Objectives. Neurotransmitter systems and neurotrophic factors can be considered strong candidates for autism spectrum disorder (ASD). The serotoninergic dopaminergic are involved in neurotransmission, brain maturation cortical organization, while (NTFs) participate neurodevelopment, neuronal survival synapses formation. We aimed to test the contribution of these candidate pathways through a case–control association study genes selected both their role central nervous system functions...
Fragile X syndrome is the most common form of inherited mental retardation. It typically caused by a mutation mental-retardation 1 (Fmr1) gene. To better understand role Fmr1 gene and its product, fragile protein in central nervous system functions, an fmr1 knockout mouse that deficient was bred. In present study, retardation 1-knockout wild-type mice are used to determine behaviour oxidative stress alterations, including reduced glutathione, oxidized glutathione thiobarbituric acid-reactive...
Background. Fragile X syndrome is the most common genetic cause of mental disability. Although many research has been performed, mechanism underlying pathogenesis unclear and needs further investigation. Oxidative stress played major roles in syndrome. The aim was to investigate nitric oxide metabolism, protein nitration level, expression NOS isoforms, furthermore activation nuclear factor NF‐ κ B‐p65 subunit different brain areas on fragile mouse model. Methods. This study involved adult...