A5030595614- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine regulation and behavior
- Peroxisome Proliferator-Activated Receptors
- Nuclear Receptors and Signaling
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- RNA regulation and disease
IVI Sevilla Clinic
2024
Instituto de Investigación Biomédica de Málaga
2024
Universidad de Sevilla
2012-2022
Real Academia Española
2020-2022
Hospital Regional Universitario de Málaga
2022
International Center of Neurologic Restoration
2015
Instituto Cajal
2013
Hospital Universitario Virgen de las Nieves
1997-2012
Universidad de Granada
2012
The University of Texas Health Science Center at San Antonio
2002
The periaqueductal grey (PAG) area is involved in pain modulation as well opiate-induced anti-nociceptive effects. PAG possess dopamine neurons, and it likely that this dopaminergic network participates anti-nociception. objective was to further study the morphology of network, along with its role nociception analgesia rats, following either depletion toxin 6-hydroxydopamine or local injection antagonists. Nociceptive responses were studied through tail-immersion (spinal reflex) hot-plate...
It has been suggested that an increase firing rate of noradrenergic neurons the locus ceruleus is responsible for opiate withdrawal syndrome. However, lesion studies have indicated are not essential either expression or suppression by clonidine withdrawal. The present study was designed to determine effect almost complete 6-hydroxydopamine (94%) on various components syndrome and its protection clonidine. Morphine dependence induced s.c. implantation morphine pellets (2 x 75 mg base)....
Nitrosative stress, where nitrosylation of tyrosine (Tyr) leading to 3-nitrotyrosine proteins or free is the most prominent change, has been proposed as a pathogenic mechanism in Parkinson's disease (PD). Levels serum and cerebrospinal fluid (CSF) patients with PD have not studied. stress-induced protein changes CSF were analyzed (n=54) controls (n=40). Herein, we demonstrate presence nitrosative stress early selective increase other than nitroalbumin, without (Hoehn-Yahr stage 1, p<0.05; 2,...
Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models several neurological disorder models, including stroke Parkinson's disease. However, there little information regarding effectiveness systemic administration OEA on In present study, OEA-mediated neuroprotection tested vivo vitro 6-hydroxydopamine (6-OH-DA)-induced degeneration. The model was...
OBJECTIVE: To generate normative data on the Rey-Osterrieth Complex Figure Test (ROCF) across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate. METHOD: The sample consisted of 3,977 he
The maximum rates of lactate oxidation and lipogenesis from by early-neonatal brain slices were considerably greater than those for utilization glucose 3-hydroxybutyrate at physiological concentrations. Lactate inhibited utilization, but enhanced utilization. 3-Hydroxybutyrate Glucose slightly 3-hydroxybutyrate, scarcely these substrates.
Abstract MDMA (3,4‐Methylenedioxymethamphetamine) is an amphetamine derivative widely used for recreational purposes. We have recently shown that repeated treatment with high doses of MDMA‐induced impairments in the acquisition and recall active avoidance task mice. In this study, we examined whether endogenous peroxisome proliferator‐activated receptor‐α (PPAR‐α) agonist, oleoylethanolamide (OEA) protects against these deficits. Mice were pretreated twice a day OEA (0, 5, 25 mg/kg) 30 min...
Abstract Oleoylethanolamide ( OEA ) is an acylethanolamide that acts as agonist of nuclear peroxisome proliferator‐activated receptor alpha PPARα to exert their biological functions, which include the regulation appetite and metabolism. Increasing evidence also suggests may participate in control reward‐related behaviours. However, direct experimental for role ‐ interaction drug‐mediated behaviours, such cocaine‐induced behavioural phenotypes, lacking. The present study explored its on...