A5070354996- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- BRCA gene mutations in cancer
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Biochemical effects in animals
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Ion Channels and Receptors
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Neurological disorders and treatments
- Pancreatic function and diabetes
- Genetic Neurodegenerative Diseases
- Genomic variations and chromosomal abnormalities
- Autophagy in Disease and Therapy
- Prenatal Substance Exposure Effects
- Nicotinic Acetylcholine Receptors Study
- Nerve injury and regeneration
- Functional Brain Connectivity Studies
University of the Basque Country
2010-2021
Achucarro Basque Center for Neuroscience
2015-2021
Euskadiko Parke Teknologikoa
2015-2016
Hospital Txagorritxu
2006-2007
The cannabinoid type 1 (CB1) receptor is widely distributed in the brain and peripheral organs where it regulates cellular functions metabolism. In brain, CB1 mainly localized on presynaptic axon terminals but also found mitochondria (mtCB1), respiration energy production. Likewise, muscle mitochondria, very little known about it. aim of this study was to further investigate detail distribution functional role mtCB1 three different striated muscles. Immunoelectron microscopy for used...
Abstract Astroglial type‐1 cannabinoid (CB 1 ) receptors are involved in synaptic transmission, plasticity and behavior by interfering with the so‐called tripartite synapse formed pre‐ post‐synaptic neuronal elements surrounding astrocyte processes. However, little is known concerning subcellular distribution of astroglial CB receptors. In particular, brain mostly localized at cells' plasmalemma, but recent evidence indicates their functional presence mitochondrial membranes. Whether present...
Astrocytes can directly influence neuronal activity through the release of various transmitters acting on membrane receptors expressed by neurons. However, in contrast to glutamate and ATP for instance, GABA (γ-amino-butyric acid) astrocytes is still poorly documented. Here, we used whole-cell recordings rat acute brain slices electron microscopy test whether hippocampal inhibitory transmitter GABA. We observed that slow transient currents due activation GABA(A) occur spontaneously principal...
Type-1 cannabinoid (CB1) and leptin (ObR) receptors regulate metabolic astroglial functions, but the potential links between two systems in astrocytes were not investigated so far. Genetic pharmacological manipulations of CB1 receptor expression activity cultured cortical hypothalamic demonstrated that signaling controls levels ObR expression. Lack also markedly impaired leptin-mediated activation signal transducers activators transcription 3 5 (STAT3 STAT5) astrocytes. In particular,...
The impact of pannexin-1 (Panx1) channels on synaptic transmission is poorly understood. Here, we show that selective block Panx1 in single postsynaptic hippocampal CA1 neurons from male rat or mouse brain slices causes intermittent, seconds long increases the frequency sEPSC following Schaffer collateral stimulation. increase occurred without an effect evoked neurotransmission. Consistent with a presynaptic origin augmented glutamate release, increased was prevented by bath-applied EGTA-AM...
Background Type-1 cannabinoid receptors (CB1R) are enriched in the hypothalamus, particularly ventromedial hypothalamic nucleus (VMH) that participates homeostatic and behavioral functions including food intake. Although CB1R activation modulates excitatory inhibitory synaptic transmission brain, contribution to molecular architecture of terminals VMH is not known. Therefore, aim this study was investigate precise subcellular distribution better understand modulation exerted by...
Abstract Binge drinking (BD) is a common pattern of ethanol (EtOH) consumption by adolescents. The brain effects the acute EtOH exposure are well‐studied; however, long‐lasting cognitive and neurobehavioral consequences BD during adolescence only beginning to be elucidated. Environmental enrichment (EE) has long been known for its benefits on may serve as potential supportive therapy following exposure. In this study, we hypothesized that EE have deficits associated with consumption....
We have recently shown that the transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel in peripheral and central nervous system, is localized at postsynaptic sites of excitatory perforant path synapses hippocampal dentate molecular layer (ML). In present work, we studied distribution TRPV1 inhibitory ML. With this aim, preembedding immunogold method for high resolution electron microscopy was applied to mouse hippocampus. About 30% ML are immunopositive, which...
Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later life. Remarkably, an enriched environment (EE) adulthood significantly recovers memory mice after adolescent BD, and the endocannabinoid, 2-arachydonoyl-glycerol (2-AG), rescues synaptic plasticity impaired adult rodents upon EtOH intake. However, mechanisms by which EE improves are unknown. We investigated this male C57BL/6J exposed to dark (DID) procedure four...
THE co-localization of GABA with AMPA receptor subunits GluR1 or GluR2/3 was analysed in the striate cortex adult rats by post-embedding immunocyto-chemistry semithin sections. Adjacent 1 μm sections four brains were alternately incubated specific antibodies against and subunits. The showed that 38% GABAergic neurons contained subunit 10% Previous work has shown immunoreactivity non-pyramidal pyramidal neurons. However, this study is first to demonstrate there are co-localized Additionally,...
Endokannabinoide-sistema (EKS) zelulen arteko komunikazio-sistema fisiologiko neuromodulatzaile garrantzitsuenetako bat da, eta helduaroan beraren funtzio ezagunena neurotransmisoreen doikuntza da. Azken urteotako ikerketek, aldiz, garrantzitsu horrez gain, garapen-prozesuetan ere parte-hartze handia duela erakutsi dute. Izan ere, zenbait artikuluk burmuinaren arauzko enbrioi-garapenerako EKSren beharra agerian utzi Enbrioi-aroko ikerketek muga metodologiko handiak dituzte, orain ikerketa...