A5055367429- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Alcohol Consumption and Health Effects
- Basque language and culture studies
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Epilepsy research and treatment
- stochastic dynamics and bifurcation
- Multiple Sclerosis Research Studies
- Sleep and related disorders
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Eicosanoids and Hypertension Pharmacology
- Neurobiology and Insect Physiology Research
- Media, Gender, and Advertising
- Cinema History and Criticism
- Aging and Gerontology Research
Achucarro Basque Center for Neuroscience
2018-2025
University of the Basque Country
2018-2025
Ikerbasque
2018-2025
Neurocentre Magendie
2012-2021
Inserm
2012-2021
Université de Bordeaux
2012-2021
Institut National de Recherche en Santé Publique
2017
Universidad Nacional Autónoma de México
2007-2010
Background and purpose: Evidence indicates that the endocannabinoid, 2‐arachidonoylglycerol (2‐AG), increases food intake when injected into nucleus accumbens shell (NAcS), thereby potentially activating hypothalamic nuclei involved in regulation. We aimed to evaluate potential orexigenic effects of endocannabinoid anandamide AA5HT, a fatty acid amide hydrolase (FAAH) inhibitor, OMDM‐1, an inhibitor uptake, NAcS, as well effect these treatments on activation nuclei. Experimental approach:...
Significance Cannabinoids and their endogenous counterparts, the so-called endocannabinoids, promote neuroprotection in laboratory animals by engaging CB 1 cannabinoid receptors, one of most abundant types receptors brain. However, assessment physiological relevance therapeutic potential receptor neurological diseases is hampered, at least part, lack knowledge neuron-population specificity action. This study shows that a unique well-defined population namely located on glutamatergic...
Complex interactions between periphery and the brain regulate food intake in mammals. Cannabinoid type-1 (CB 1 ) receptor antagonists are potent hypophagic agents, but sites where this acute action is exerted underlying mechanisms not fully elucidated. To dissect effect of CB blockade, we combined injection antagonist rimonabant with use conditional -knockout mice, as well pharmacological modulation different central peripheral circuits. Fasting/refeeding experiments revealed that signaling...
Abstract Astroglial type‐1 cannabinoid (CB 1 ) receptors are involved in synaptic transmission, plasticity and behavior by interfering with the so‐called tripartite synapse formed pre‐ post‐synaptic neuronal elements surrounding astrocyte processes. However, little is known concerning subcellular distribution of astroglial CB receptors. In particular, brain mostly localized at cells' plasmalemma, but recent evidence indicates their functional presence mitochondrial membranes. Whether present...
To maximize their chances of survival, animals need to rapidly and efficiently respond aversive situations. These responses can be classified as active or passive depend on the specific nature threats, but also individual fear coping styles. In this study, we show that control excitatory inhibitory brain neurons by type-1 cannabinoid (CB 1 ) receptors is a key determinant strategies in mice. classical conditioning, switch between initially predominant (freezing) behaviors (escape attempts...
Type-1 cannabinoid (CB1) and leptin (ObR) receptors regulate metabolic astroglial functions, but the potential links between two systems in astrocytes were not investigated so far. Genetic pharmacological manipulations of CB1 receptor expression activity cultured cortical hypothalamic demonstrated that signaling controls levels ObR expression. Lack also markedly impaired leptin-mediated activation signal transducers activators transcription 3 5 (STAT3 STAT5) astrocytes. In particular,...
<ns4:p>The endocannabinoid system (ECS) is abundantly expressed in the brain. This regulates a plethora of physiological functions and composed cannabinoid receptors, their endogenous ligands (endocannabinoids), enzymes involved metabolism endocannabinoids. In this review, we highlight new advances signaling, focusing on key component ECS, type-1 receptor (CB<ns4:sub>1</ns4:sub>). recent years, development imaging molecular tools has demonstrated that can be distributed many cell types...
Activation of type 1 cannabinoid receptors (CB1R) decreases GABA and glutamate release in cortical subcortical regions, with complex outcomes on network activity. To date there have been few attempts to disentangle the region- cell-specific mechanisms underlying effects cannabinoids activity vivo. Here we addressed this issue by combining vivo electrophysiological recordings local systemic pharmacological manipulations conditional mutant mice lacking CB1R expression different neuronal...
We present lateral habenula (LHb) neural data that display a variety of bursting patterns, with two dominant types and third one appears as mix the other two. analyse these patterns using elementary statistical tools characterise them from perspective average frequency during burst duration, which yields main categories. then propose an idealised multiple-timescale dynamical model captures observed in data, namely square-wave parabolic bursting, well intermediate mixed-type (also termed...
The lack of intrinsic motivation to engage in, and adhere to, physical exercise has major health consequences. However, the neurobiological bases are still unknown. This study aimed at examining whether endocannabinoid system (ECS) is involved in this process. To do so, we developed an operant conditioning paradigm wherein mice unlocked a running wheel with nose pokes. Using pharmacological tools conditional mutants for cannabinoid type-1 (CB1) receptors, provide evidence that CB1 receptors...