A5050996107- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Microtubule and mitosis dynamics
- Pancreatic function and diabetes
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
Université de Bordeaux
2016-2024
Centre National de la Recherche Scientifique
2020-2024
Institut Interdisciplinaire de Neuroscience
2020-2024
Albert Einstein College of Medicine
2024
University of Catania
2023
Institut national de recherche en informatique et en automatique
2023
Neurocentre Magendie
2016-2023
Inserm
2016-2023
Institut de Mathématiques de Bordeaux
2023
Centre de Recherche Inria Bordeaux - Sud-Ouest
2023
Behavioral states such as sleep and wake are highly correlated with specific patterns of rhythmic activity in the cortex. During low arousal slow wave sleep, cortex is synchronized dominated by frequency rhythms coordinated across multiple regions. Although recent evidence suggests that GABAergic inhibitory neurons key players cortical state modulation,
Abstract Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated central neuronal circuits. In the cortex, desynchronized states associate with high signal-to-noise ratio stimulus-evoked responses heightened perception. Cannabinoid-type-1-receptors (CB1Rs) - which influence coordination in hippocampus are present anterior piriform cortex (aPC), a paleocortex supporting olfactory Yet, how CB1Rs shape...
Abstract Despite the central role of Rho GTPases in neuronal development, their functions adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach vivo, we show that atypical GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional maturation adult-born dentate granule neurons. Interestingly, most these are specific to neurons generated during adulthood since deletion neonatally-born only affects...
Abstract One of the most important functions GABAergic inhibition in cortical regions is tight control spatiotemporal activity principal neuronal ensembles. However, electrophysiological recordings do not provide sufficient spatial information to determine properties inhibitory plasticity. Using Voltage Sensitive Dye Imaging (VSDI) mouse hippocampal slices, we demonstrate that GABA A -mediated field postsynaptic potentials undergo layer-specific potentiation upon activation metabotropic...
SUMMARY The idea that the effects of drugs largely depend on subcellular target location is emerging as a novel predictive factor their beneficial or adverse outcomes. G protein-coupled type-1 cannabinoid receptors (CB 1 ) are regulators several brain functions well main targets cannabinoid-based medicines. Besides classical at plasma membranes, CB present different locations within cells, including in association to mitochondrial membranes (mtCB ). Here we report generation and...
Abstract Brain activity and breathing rate influence each other but it remains unclear how fine respiratory features vary across vigilance states. Using simultaneous nasal pressure hippocampal local field potential recordings in freely-moving mice, we show that the position of pauses within cycles distinguish Wake, Rapid Eye Movement (REM) non-REM (NREM) sleep Model-based predictions states based on perform well even animals outside training set, suggesting rules are generalized. Respiratory...
Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of a sufficient condition improve performance remains unclear. Here, we developed validated, using ex-vivo electrophysiology, chemogenetic approach that combines selective tagging activation discrete adult-born neuron populations. Then demonstrated that, rats, this can accuracy strength remote memory. These results show activity counteract...
ABSTRACT Despite the central role of Rho GTPases in neuronal development, their functions adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach vivo , we show that atypical GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis and functional maturation adult-born dentate granule neurons. Interestingly, most these are specific to neurons generated during adulthood since deletion neonatally-born only affects...
For many years, voltage sensitive dye imaging (VSDI) has enabled the fruitful analysis of neuronal transmission by monitoring spreading signals. Although useful, display diffusion depolarization provides insufficient information in quest for a greater understanding computation brain function. Here, we propose optimal mass transportation theory as model to describe dynamics activity. More precisely, use solution an L 2 -Monge–Kantorovich problem VSDI data, extract velocity and overall...
Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of a sufficient condition improve performance remains unclear. Here, we developed validated, using ex-vivo electrophysiology, chemogenetic approach that combines selective tagging activation discrete adult-born neuron populations. Then demonstrated that, rats, this can accuracy strength remote memory. These results show neurons counteract...
Abstract Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of can improve performance remains unclear. Here, using a chemogenetic approach that combines selective tagging specific activation distinct adult-born neuron populations, we demonstrate this remote accuracy strength. These results open up new avenues for remedying problems may arise over time.