A5037093632- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Regulation of Appetite and Obesity
- Pelvic floor disorders treatments
- Memory and Neural Mechanisms
- Colorectal and Anal Carcinomas
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Inflammatory Bowel Disease
- Stoma care and complications
- Gastric Cancer Management and Outcomes
- Neuroendocrine regulation and behavior
- Enhanced Recovery After Surgery
- Congenital heart defects research
- Down syndrome and intellectual disability research
- Gastrointestinal motility and disorders
Inserm
2015-2022
Neurocentre Magendie
2015-2022
Université de Bordeaux
2015-2022
Bioscience (China)
2022
Instituto de Neurociencias
2019
Michigan State University
1978-1997
Grand Rapids Community College
1990-1991
Ferguson Library
1971-1989
Anastomotic stenosis is a poorly understood and underexamined complication of gastrointestinal surgery, reportedly most frequent in the coloproctostomy. In order to better define this problem, questionnaire was sent members American Society Colon Rectal Surgeons regarding patients with anastomotic stenosis. A total 123 intestinal were analyzed. Eighty-two anastomoses stapled 41 handsewn. Nearly all stenoses occurred distal bowel (70 rectal, 23 sigmoid colon). Preoperative risk factors...
Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones human ecosystem and prevent adipogenesis. The objectives present study were demonstrate antiobesity potential new strain Christensenella minuta in preclinical models explore related mechanisms action. C. DSM33407 was assessed diet-induced obesity mouse model. Changes hepatic lipid metabolism...
aActive Staff 1Ferguson Clinic, Grand Rapids, Michigan Read at the meeting of American Proctologic Society, Hollywood, Florida, April 12 to 16, 1970.
Abstract Background There is a growing interest in using gut commensal bacteria as “next generation” probiotics. However, this approach still hampered by the fact that there are few or no strains available for specific species difficult to cultivate. Our objective was adapt flow cytometry and cell sorting be able detect, separate, isolate, cultivate new of from fecal material. We focused on extremely oxygen sensitive (EOS) Faecalibacterium prausnitzii under-represented, health-associated...
Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions poorly defined. Using conditional mutagenesis and chemogenetics, we show blockade of the energy sensor mechanistic target rapamycin complex 1 (mTORC1) in POMC causes hyperphagia by mimicking a cellular negative state. This is associated with decreased...
Abstract Memory reconsolidation, the process by which memories are again stabilized after being reactivated, has strengthened idea that memory stabilization is a highly plastic process. To date, molecular and cellular bases of reconsolidation have been extensively investigated particularly within hippocampus. However, role adult neurogenesis in unclear. Here, we combined functional imaging, retroviral chemogenetic approaches rats to tag manipulate different populations rat adult-born...
Microbiome-based therapies for inflammatory bowel diseases offer a novel and promising therapeutic approach. The human commensal bacteria of the species Christensenella minuta (C. minuta) have been reported consistently missing in patients affected by Crohn's disease (CD) documented to induce anti-inflammatory effects epithelial cells, supporting their potential as biotherapy. This work aimed at selecting most strain C. future development clinical candidate CD therapy. Here, we describe...
During the last decade, a plethora of novel therapies containing live microorganisms as active substance(s) has emerged with aim to treat, prevent, or cure diseases in human beings. Both Food and Drug Administration (FDA) European Directorate for Quality Medicines Health Care (EDQM) codified these biotherapies Live Biotherapeutic Products (LBPs). While innovative products offer healthcare opportunities, they also represent challenge developers who need set most suitable designs non-clinical...
Abstract Overinhibition is assumed one of the main causes cognitive deficits (e.g. memory impairment) in mouse models Down syndrome (DS). Yet mechanisms that drive such exaggerated synaptic inhibition and their behavioral effects remain unclear. Here we report existence bidirectional alterations to on CA1 pyramidal cells Ts2Cje model DS which are associated impaired spatial memory. Furthermore, identify triplication kainate receptor (KAR) encoding gene Grik1 as cause these phenotypes....
Abstract The dentate gyrus is one of the only brain regions that continues its development after birth in rodents. Adolescence a very sensitive period during which cognitive competences are programmed. We investigated role granule neurons (DGNs) born adolescence spatial memory and compared them with those generated earlier life (in embryos or neonates) adulthood by combining functional imaging, retroviral optogenetic tools to tag silence DGNs. By imaging DGNs expressing Zif268, proxy for...
Approximately 30 percent of patients undergoing anorectal surgery will develop acute urinary retention. The cause this complication is poorly understood. Anxiety, anal distention, bladder distention as a result vigorous hydration during surgery, and reflex inhibition the detrusor muscle secondary to pain have been postulated contributing factors. A four-armed prospective, double-blind, randomized trial was carried out determine whether an anxiolytic agent (midazolam, 5 mg intramuscularly)...
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The hypothalamic paraventricular nucleus (PVN) is a key target of the melanocortin system, which orchestrates behavioral and metabolic responses depending on energy availability. mechanistic rapamycin complex 1 (mTORC1) endocannabinoid type receptor (CB1R) pathways are two signaling systems involved in regulation balance whose activity closely depends upon Here we tested hypothesis that modulation mTORC1 CB1R regulates excitatory glutamatergic inputs onto PVN.Patch-clamp recordings C57BL/6J...
One hundred patients with permanent sigmoid colostomies were surveyed to determine their satisfaction and success the “irrigation” technique of colostomy management. Most who irrigate achieve continence. Odors skin irritations are minimized. The irrigation method is economical, time efficient, allows a reasonably liberal diet. It avoids bulky appliances safe. In appropriately selected patients, choice for management an end-sigmoid colostomy.