A5020421797- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Human-Animal Interaction Studies
- Animal Behavior and Welfare Studies
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Cannabis and Cannabinoid Research
- Fatty Acid Research and Health
- Eating Disorders and Behaviors
- Animal Nutrition and Physiology
- Advanced Chemical Sensor Technologies
- Spectroscopy and Quantum Chemical Studies
- Molecular spectroscopy and chirality
NutriNeuro
2016-2025
Université de Bordeaux
2016-2025
Institut Polytechnique de Bordeaux
2019-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2025
Universidade Federal da Fronteira Sul
2024
Institut National de la Recherche Agronomique
2008-2015
Physiologie de la Reproduction et des Comportements
2001-2010
Centre National de la Recherche Scientifique
2001-2010
Université de Tours
2001-2010
Institute of Neuroimmunology of the Slovak Academy of Sciences
2007-2010
Abstract Increased consumption of high‐fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood adolescence are important periods brain maturation shaping cognitive function. These could consequently be particularly sensitive the detrimental effects HFD intake. In mice, juvenile adulthood induce similar morphometric metabolic changes. However, only exposure abolishes relational memory flexibility, assessed after initial radial‐maze concurrent spatial discrimination...
Converging clinical data suggest that peripheral inflammation is likely involved in the pathogenesis of neuropsychiatric symptoms associated with metabolic syndrome (MetS). However, question arises as to whether increased prevalence behavioral alterations MetS also central inflammation, i.e. cytokine activation, brain areas particularly controlling behavior. To answer this question, we measured a mouse model MetS, namely diabetic and obese db/db mice, their healthy db/+ littermates emotional...
The medial prefrontal cortex (mPFC) has long been considered a critical site in action control. However, recent evidence indicates that the contribution of cortical areas to goal-directed behavior likely extends beyond mPFC. Here, we examine function both insular (IC) and ventrolateral orbitofrontal (vlOFC) cortices action-dependent learning. We used chemogenetics study consequences IC or vlOFC inhibition on acquisition performance instrumental actions using outcome devaluation task. Rats...
Abstract Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution ED symptomatic dimensions remains unclear. Using chemogenetic manipulations male mice, we found that activity dopamine D1 receptor-expressing neurons NAc core subregion facilitated effort for a food reward as well voluntary exercise, but decreased intake, while D2-expressing have opposite effects. These effects are congruent with D2-neurons being...
Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes. We have previously shown IL-1beta synthesis hippocampus dependent on P2X(7) receptor (P2X(7)R), an ionotropic of ATP. To substantiate role P2X(7)R both expression and processes, we examined induction mRNA wild-type (WT) homozygous knockout mice (P2X(7)R(-/-)) following spatial task. The recognition task induced c-Fos...
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive emotional outcomes. Its growing prevalence during adolescence particularly alarming since recent evidence indicates that can affect hippocampal function this developmental period. Adolescence a decisive period for maturation of the amygdala hypothalamic-pituitary-adrenal (HPA) stress axis, both required lifelong processing. However, little data are available on impact function. Herein, we...
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive emotional outcomes. Its growing prevalence in adolescents particularly alarming since this a period of ongoing maturation for brain structures (including the hippocampus amygdala) hypothalamic-pituitary-adrenal (HPA) stress axis, which required processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads impaired hippocampal function enhanced amygdala...
Abstract The limbic circuit is still undergoing maturation during juvenility and adolescence, explaining why environmental metabolic challenges these developmental periods can have specific adverse effects on cognitive functions. We previously shown that long-term exposure (8–12 weeks) to high-fat diet (HFD) adolescence (from weaning adulthood), but not at adulthood, was associated with altered amygdala hippocampal Moreover, HFD were normalized by treatment glucocorticoid receptor (GR)...
Obesity is associated with neurocognitive dysfunction, including memory deficits. This particularly worrisome when obesity occurs during adolescence, a maturational period for brain structures critical cognition. In rodent models, we recently reported that impairments induced by obesogenic high-fat diet (HFD) intake the periadolescent can be reversed chemogenetic manipulation of ventral hippocampus (vHPC). Here, used an intersectional viral approach in HFD-fed male mice to chemogenetically...
Astrocytes control brain activity via both metabolic processes and gliotransmission, but the physiological links between these functions are scantly known. Here we show that endogenous activation of astrocyte type-1 cannabinoid (CB1) receptors determines a shift glycolysis towards lactate-dependent production D-serine, thereby gating synaptic cognitive in male mice. Mutant mice lacking CB1 receptor gene astrocytes (GFAP-CB1-KO) impaired novel object recognition (NOR) memory. This phenotype...
Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In present study, we used sensitization to amphetamine investigate effect periadolescent HFD exposure (pHFD) in rats on functionality dopamine (DA) system, a central actor food reward processing. pHFD does not affect responding an acute injection, however, single is sufficient induce...
Abstract Memory reconsolidation, the process by which memories are again stabilized after being reactivated, has strengthened idea that memory stabilization is a highly plastic process. To date, molecular and cellular bases of reconsolidation have been extensively investigated particularly within hippocampus. However, role adult neurogenesis in unclear. Here, we combined functional imaging, retroviral chemogenetic approaches rats to tag manipulate different populations rat adult-born...
Abstract Background Highly caloric food consumed around the clock perturbs metabolism and cognitive functioning. We hypothesized that obesogenic could alter neuronal representations of memory depending on feeding-fasting cycle. Methods tracked performance, dendritic spine dynamics in C57Bl6J mice fed ad libitum from peri-adolescence. aimed to correct energy rich diet-induced plasticity deficits impairment with time-restricted feeding males females. further used chemogenetics, pharmacology...