A5053388087- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Diet and metabolism studies
- Pancreatic function and diabetes
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Dietary Effects on Health
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Mitochondrial Function and Pathology
- Amino Acid Enzymes and Metabolism
- Neural dynamics and brain function
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Prenatal Substance Exposure Effects
Neurocentre Magendie
2016-2025
Inserm
2016-2025
Université de Bordeaux
2016-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2025
University of Catania
2023
Institut de Mathématiques de Bordeaux
2023
Institut national de recherche en informatique et en automatique
2023
Institut Interdisciplinaire de Neuroscience
2020-2023
Centre National de la Recherche Scientifique
2021-2023
Centre de Recherche Inria Bordeaux - Sud-Ouest
2023
Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge have been postulated. We generated conditional mutant mice that lack expression cannabinoid receptor type 1 in principal forebrain but not adjacent inhibitory interneurons. In mice,the excitotoxin kainic acid (KA) induced excessive seizures vivo. The threshold KA-induced neuronal excitation vitro was severely reduced hippocampal pyramidal mutants. KA...
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in regulation of food intake. Here we show that lack CB1 mice with a disrupted gene causes hypophagia leanness. As compared WT (CB1+/+) littermates, lacking (CB1-/-) exhibited reduced spontaneous caloric intake and, as consequence total fat mass, decreased body weight. In young CB1-/- mice, lean phenotype is predominantly caused by intake, whereas adult metabolic factors appear to contribute...
Cannabinoids can modulate motor behaviour, learning and memory, cognition pain perception. These effects correlate with the expression of cannabinoid receptor 1 (CB1) presence endogenous cannabinoids in brain. In trying to obtain further insights into mechanisms underlying modulatory cannabinoids, CB1-positive neurons were determined murine forebrain at a single cell resolution. We performed double situ hybridization study detect mRNA CB1 combination glutamic acid decarboxylase 65k,...
The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB 1 cannabinoid receptors (CB Rs) enriched in the axonal growth cones γ-aminobutyric acid–containing (GABAergic) interneurons rodent cortex late gestation. Endocannabinoids trigger R internalization and elimination from filopodia induce chemorepulsion collapse these GABAergic by activating RhoA. Similarly, endocannabinoids diminish galvanotropism Xenopus laevis spinal neurons. These...
Diet-induced obesity is associated with fatty liver, insulin resistance, leptin and changes in plasma lipid profile. Endocannabinoids have been implicated the development of these phenotypes, because mice deficient for cannabinoid receptor CB1 (CB1–/–) do not display association diet-induced obesity. The target tissues that mediate effects, however, remain unknown. We therefore investigated relative role hepatic versus extrahepatic receptors metabolic consequences a high-fat diet, using...
Excessive inflammatory responses can emerge as a potential danger for organisms' health. Physiological balance between pro- and anti-inflammatory processes constitutes an important feature of against harmful events. Here, we show that cannabinoid receptors type 1 (CB1) mediate intrinsic protective signals counteract proinflammatory responses. Both intrarectal infusion 2,4-dinitrobenzene sulfonic acid (DNBS) oral administration dextrane sulfate sodium induced stronger inflammation in...
Excessive inflammatory responses can emerge as a potential danger for organisms' health.Physiological balance between pro-and anti-inflammatory processes constitutes an important feature of against harmful events.Here, we show that cannabinoid receptors type 1 (CB1) mediate intrinsic protective signals counteract proinflammatory responses.Both intrarectal infusion 2,4-dinitrobenzene sulfonic acid (DNBS) and oral administration dextrane sulfate sodium induced stronger inflammation in...
Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in developing cerebrum. However, eCB functions during pyramidal cell specification and establishment long-range axonal connections are unknown. Here, we show that signaling is operational subcortical proliferative zones from embryonic day 12 mouse telencephalon controls proliferation progenitors radial migration immature cells. When layer patterning...
Counteracting Cannabis What is the role of steroid hormones in vulnerability to addiction? Working with rodents, Vallée et al. (p. 94 ) found that all major drugs abuse (morphine, cocaine, alcohol, nicotine) increase neurosteroid levels, active ingredient cannabis (THC) inducing a particularly large increase. THC and other increased levels pregnenolone, long thought be an inactive precursor downstream steroids. Pregnenolone antagonized most known behavioral somatic effects THC.