A5021919091- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Pain Management and Placebo Effect
- Photoreceptor and optogenetics research
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Musculoskeletal pain and rehabilitation
- Acupuncture Treatment Research Studies
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
University of Buenos Aires
2001-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2020-2023
University of Bern
2020-2023
Neurocentre Magendie
2009-2015
Inserm
2009-2015
Université de Bordeaux
2010-2015
Chronic exposure to drugs of abuse induces countless modifications in brain physiology. However, the neurobiological adaptations specifically associated with transition addiction are unknown. Cocaine self-administration rapidly suppresses long-term depression (LTD), an important form synaptic plasticity nucleus accumbens. Using a rat model addiction, we found that animals progressively develop behavioral hallmarks have permanently impaired LTD, whereas LTD is recovered nonaddicted rats...
Counteracting Cannabis What is the role of steroid hormones in vulnerability to addiction? Working with rodents, Vallée et al. (p. 94 ) found that all major drugs abuse (morphine, cocaine, alcohol, nicotine) increase neurosteroid levels, active ingredient cannabis (THC) inducing a particularly large increase. THC and other increased levels pregnenolone, long thought be an inactive precursor downstream steroids. Pregnenolone antagonized most known behavioral somatic effects THC.
In vivo, cortical neurons and striatal medium spiny (MSN) display robust subthreshold depolarizations (Up states) during which they are enabled to fire action potentials. the cortex, Up states believed occur simultaneously in a neuronal ensemble be sustained by local network interactions. It is known that MSN impelled into state extra-striatal (primarily cortical) inputs, but mechanisms sustain determine end of still debated. Furthermore, it has not been established if brisk perturbations...
Neurons in the basal ganglia output nuclei display rhythmic burst firing after chronic nigrostriatal lesions. The thalamocortical network is a strong endogenous generator of oscillatory activity, and striatum receives massive projection from cerebral cortex. Actually, membrane potential striatal neurons displays periodic shifts between very negative resting (down state) depolarizing plateaus (up states) during which they can fire action potentials. We hypothesized that an increased...
Activation of glucocorticoid receptors (GR) by hormones (GC) enhances contextual fear memories through the activation Erk1/2(MAPK) signaling pathway. However, molecular mechanism mediating this effect GC remains unknown. Here we used complementary and behavioral approaches in mice rats genetically modified which GR was conditionally deleted (GR(NesCre)). We identified tPA-BDNF-TrkB pathway as upstream effectors GR-mediated phosphorylation responsible for enhancement memory. These findings...
In anaesthetised animals, the very negative resting membrane potential of striatal spiny neurones (down state) is interrupted periodically by depolarising plateaux (up states) which are probably driven excitatory input. absence active synaptic input, as occurs in vitro , potassium currents hold down state. Because fire action potentials only during up state, these plateau depolarisations have been perceived enabling events that allow information processing through cerebral cortex‐basal...
Adolescence is characterized by drastic behavioral adaptations and comprises a particularly vulnerable period for the emergence of various psychiatric disorders. Growing evidence reveals that pathophysiology these disorders might derive from aberrations normal neurodevelopmental changes in adolescent brain. Understanding molecular underpinnings behavior therefore critical understanding origin psychopathology, but mechanisms trigger are unknown. Here, we hypothesize cannabinoid type-1...
The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However, the involved regions are not specific for pain. Thus, how cortex distinguishes nociception other aversive salient stimuli remains elusive. Additionally, resulting consequences chronic neuropathic on processing have been characterized. Using in vivo miniscope calcium imaging with cellular resolution freely moving mice, we elucidated principles nociceptive...
Abstract A high proportion of neurons in the basal ganglia display rhythmic burst firing after chronic nigrostriatal lesions. For instance, periodic bursts exhibited by certain striatal and subthalamic nucleus 6‐hydroxydopamine‐lesioned rats seem to be driven ∼ 1 Hz high‐amplitude rhythm that is prevalent cerebral cortex anaesthetized animals. Because striatum are main afferent structures substantia nigra pars reticulata, we examined possibility low‐frequency modulations (periodic bursts)...
Precise control of synaptic strength is critical for maintaining accurate network activity and normal brain functions. Several major diseases are related to alterations in the adult brain. Detailed descriptions physiological properties synapses scarce, mainly because difficulties performing whole cell patch-clamp recording slices from animals. Here we present portrait excitatory intrinsic medium spiny neurons (MSNs) nucleus accumbens (NAc), a central structure mesocorticolimbic system, youth...
Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome such remains be identified. Here, we examined whether plateau depolarizations (UP states) relate better active epochs local field potentials recorded from closely related areas than...
Abstract Neuropathic pain induces changes in neuronal excitability and synaptic connectivity deep layers of the anterior cingulate cortex (ACC) that play a central role sensory, emotional affective consequences disease. However, how this impacts ACC vivo activity is not completely understood. Using mouse model, we found neuropathic caused an increase activity, as measured by indirect marker c-Fos juxtacellular electrophysiological recordings. The enhanced firing rate neurons lesioned animals...
Abstract The perception of pain arises from distributed brain activity triggered by noxious stimuli. However, which patterns make nociception distinct other salient sensory experiences is still unknown. Using in vivo chronic two-photon calcium imaging slightly anaesthetized mice, we identified a nociception-specific representation the anterior cingulate cortex (ACC), that attained core neurons code for generalized concept experience. overall ensemble allowed an efficient discrimination...
Maladaptive neuronal plasticity is a main mechanism for the development and maintenance of pathological pain. Affective, motivational cognitive deficits that are comorbid with pain involve cellular synaptic modifications in anterior cingulate cortex (ACC), major brain mediator perception. Here we use model neuropathic (NP) male mice ex-vivo electrophysiology to investigate whether layer 5 ACC neurons projecting dorsomedial striatum (DMS), critical region regulation behavior, involved...