A5089506479- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Helicobacter pylori-related gastroenterology studies
- Hypothalamic control of reproductive hormones
- Gastrointestinal motility and disorders
- Pancreatic function and diabetes
- Nerve injury and regeneration
- Biochemical Analysis and Sensing Techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Gastroesophageal reflux and treatments
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Peptidase Inhibition and Analysis
- Circadian rhythm and melatonin
- S100 Proteins and Annexins
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Diabetes and associated disorders
University of Cagliari
2015-2024
University of Bologna
1981-2015
Medica (Italy)
2015
Oasi Maria SS
1994-2000
Istituti di Ricovero e Cura a Carattere Scientifico
1994-2000
University of Rome Tor Vergata
1984-1990
Hammersmith Hospital
1982-1988
Montreal Clinical Research Institute
1988
London Postgraduate Medical and Dental Education
1985-1986
Musashigaoka College
1986
Excessive inflammatory responses can emerge as a potential danger for organisms' health. Physiological balance between pro- and anti-inflammatory processes constitutes an important feature of against harmful events. Here, we show that cannabinoid receptors type 1 (CB1) mediate intrinsic protective signals counteract proinflammatory responses. Both intrarectal infusion 2,4-dinitrobenzene sulfonic acid (DNBS) oral administration dextrane sulfate sodium induced stronger inflammation in...
Excessive inflammatory responses can emerge as a potential danger for organisms' health.Physiological balance between pro-and anti-inflammatory processes constitutes an important feature of against harmful events.Here, we show that cannabinoid receptors type 1 (CB1) mediate intrinsic protective signals counteract proinflammatory responses.Both intrarectal infusion 2,4-dinitrobenzene sulfonic acid (DNBS) and oral administration dextrane sulfate sodium induced stronger inflammation in...
Abstract The neuropeptide oxytocin (20–100 ng), induces penile erection when injected unilaterally into the caudal but not rostral mesencephalic ventral tegmental area (VTA) of male Sprague–Dawley rats. Such pro‐erectile effect started 30 min after treatment and was abolished by prior injection d(CH 2 ) 5 Tyr(Me) ‐Orn 8 ‐vasotocin (1 µg), an receptor antagonist same or haloperidol a dopamine antagonist, either nucleus accumbens shell (NAs) paraventricular hypothalamus (PVN) ipsilateral to...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield incompletely characterized panel of neuropeptides. Until now, it was unproved assumption VGF-derived peptides could regulate metabolism. Here, VGF peptide designated TLQP-21 in rat brain extracts by means immunoprecipitation, microcapillary liquid chromatography-tandem MS, and database searching algorithms. Chronic intracerebroventricular (i.c.v.) injection...
Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it generally believed that its expression function are limited to bone marrow-derived cells. Here, we report the identification characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell lines tumour tissue samples. p65BTK protein expressed, through heterogeneous nuclear ribonucleoprotein K (hnRNPK)-dependent internal ribosome entry site-driven translation, from transcript...
Diagnosis of dementia with Lewy bodies (DLB) is challenging, largely due to a lack diagnostic tools. Cerebrospinal fluid (CSF) biomarkers have been proven useful in Alzheimer's disease (AD) diagnosis. Here, we aimed identify novel CSF for DLB using high-throughput proteomic approach.We applied liquid chromatography/tandem mass spectrometry label-free quantification biomarker candidates individual samples from well-characterized cohort comprising patients (n = 20) and controls 20). Validation...
The pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) is widely unknown, and the role autoantibodies still undetermined.
Abstract VGF mRNA and its precursor‐derived products are selectively expressed in certain neurons promptly respond to neurotrophins neural/electrical activity. Proteomic studies have previously revealed a reduction some peptides the cerebrospinal fluid of patients affected by Alzheimer’s disease other conditions, suggesting their potential diagnostic clinical significance. As presence within human cortex has been somewhat elucidated, they were studied postmortem frontal, parietal, temporal...
Abstract Oxytocin (80 ng) injected into the caudal mesencephalic ventral tegmental area (VTA) of male rats induces penile erection. Such an effect occurs together with increase in nitric oxide (NO) production, as measured by augmented concentration NO 2 − and 3 found dialysate obtained from this brain means intracerebral microdialysis. Both effects are abolished d(CH ) 5 Tyr(Me) ‐Orn 8 ‐vasotocin (1 μg), oxytocin receptor antagonist, S‐methyl‐ l ‐thiocitrulline acetate (20 a neuronal...
Aim: To assess the role of lithium treatment in relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL 131 patients with BD, or without a history treatment, 336 controls. tested association genetically determined BD two large genome-wide datasets. Results: Patients showed longer never-treated (p = 0.015), similar never treated shorter controls 0.029). Mendelian randomization analysis no LTL. Conclusion: Our data support previous...
During migration and for about 2 days after their arrival in the gonadal ridges, primordial germ cells (the embryonic precursors of gametes adult animal) proliferate actively. Certain growth factors, such as stem cell factor leukemia inhibitory factor, seem to be essential survival, proliferation possibly differentiation mouse vivo and/or vitro. Similarly, increase intracellular cAMP is followed by a marked enhancement proliferation, at least culture. In present study, we show that pituitary...
Abstract: VGF is a neuroendocrine‐specific gene product that up‐regulated by nerve growth factor in the PC12 cell line. In rat neuroendocrine tissues two polypeptides of 90 and 80 kDa were detected an antiserum to N‐terminal domain (from residues 4 240). parallel, directed against C‐terminal nonapeptide 609 617) revealed several additional posttranslational products. Peptides apparent molecular sizes 20, 18, 10 prominent hypophysis but absent adrenal medulla, their relative abundance varied...