A5100339143- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- stochastic dynamics and bifurcation
- Neurotransmitter Receptor Influence on Behavior
- Nonlinear Dynamics and Pattern Formation
- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Chaos control and synchronization
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Neural Networks and Applications
- Inflammasome and immune disorders
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Language, Metaphor, and Cognition
- Adipose Tissue and Metabolism
Shaanxi Normal University
2016-2025
Southwest Medical University
2022-2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2024
Chongqing Medical University
2017-2024
Betta Pharmaceuticals (China)
2020-2024
Southern Medical University Shenzhen Hospital
2023-2024
Capital Medical University
2023-2024
Beijing Tian Tan Hospital
2022-2024
Ca2+ influx via GluR2-lacking Ca2+-permeable AMPA glutamate receptors (CP-AMPARs) can trigger changes in synaptic efficacy both interneurons and principle neurons, but the underlying mechanisms remain unknown. We took advantage of genetically altered mice with no or reduced GluR2, thus allowing expression CP-AMPARs, to investigate molecular signaling process during CP-AMPAR-induced plasticity at CA1 synapses hippocampus. Utilizing electrophysiological techniques, we demonstrated that these...
Abstract Neuroadaptations in the nucleus accumbens (NAc) are associated with development of drug addiction. Plasticity synaptic strength and intrinsic excitability NAc medium spiny neurons (MSNs) play critical roles addiction induced by different classes abused drugs. However, it is unknown whether morphine exposure influences strength, or both NAc. Here we show that chronic withdrawal (10 days after last injection) from repeated elicited potentiation glutamatergic MSNs shell (NAcSh). The...
Scope A high salt (HS) diet is detrimental to cognitive function, in addition having a role cardiovascular disorders. However, the method by which an HS impairs functions such as learning and memory remains open. Methods results In this study, we found that mice on 7 week demonstrated disturbed short‐term object‐place recognition task, both 4 treatments impaired long‐term memory, evidenced fear conditioning test. Mechanistically, inhibited memory‐related potentiation (LTP) hippocampus, while...
Stressful life events induce abnormalities in emotional and cognitive behaviour. The endogenous opioid system plays an essential role stress adaptation coping strategies. In particular, the µ-opioid receptor (μR), one of major receptors, strongly influences memory processing that alterations μR signalling are associated with various neuropsychiatric disorders. However, it remains unclear whether contributes to impairments induced by acute stress. Here, we utilized pharmacological methods...
The dynamics of the generation various spike trains in neural pacemakers is fundamental importance to understanding coding. Recent studies have demonstrated, theoretically and experimentally, that produce chaotic oscillations. Deeper analyses several neuronal models revealed many nonlinear phenomena including period-adding bifurcations whose existence has not been experimentally confirmed. In this letter, we reported bifurcation with chaos was observed interspike interval (ISI) series...
Some chaotic and a series of stochastic neural firings are multimodal. Stochastic multimodal firing patterns special importance because they indicate possible utility noise. A number previous studies confused the dynamics patterns. The confusion resulted partly from inappropriate interpretations estimations nonlinear time measures. With deliberately chosen examples present paper introduces strategies methods identification ones. Aided by theoretical simulation we show that result effects...
Anxiety is a very common negative emotional status induced by stress. However, its underlying neural mechanism still largely unknown. Here, we found hypothalamic section named the supramammillary nucleus (SuM), which taking control of anxiety. We then characterized small ensemble stress-activated neurons and recruited encoding These specifically respond to stress, activation robustly increases anxiety-like behavior mice without significantly influencing fear memory. that ventral subiculum...
Sequestrated thoracic disc herniation following a minor traumatic event without an apparent spinal fracture or dislocation is extremely rare condition. Evaluation of young morbid obese male with acute paraparesis secondary to accidently sitting down the floor revealed right-sided extruded at level T7-8 and T8-9. At 12-month follow-up, he made dramatic recovery appropriate surgical intervention. As soon as occurrence event, Magnetic Resonance Imaging (MRI) spine necessary, even in absence...
Coherence resonance at a saddle-node bifurcation point and the corresponding stochastic firing patterns are simulated in theoretical neuronal model. The characteristics of noise-induced neural pattern, such as exponential decay histogram interspike interval (ISI) series, independence stochasticity within ISI series identified. Firing pattern similar to results was discovered biological experiment on pacemaker. difference between this integer multiple generated Hopf is also given. not only...
<title>Abstract</title> Background Mu-opioid receptors (MORs) are critical regulators mediating the modulation of several behavioral reactions, including analgesia, addiction, and sedation. Recent studies have reported that MORs closely associated with mood disorders or anxiety behaviors; however, underlying neural mechanisms remain unclear. The periaqueductal gray (PAG), a key brain area, participates in aversive emotional behaviors. show high expression ventrolateral PAG (vlPAG) region....
The inter-burst intervals (IBIs) of the stochastic bursting caused by effect coherence resonance (CR) in Hindmarsh-Rose model exhibited multiple mode and were approximately integer multiples a basic IBI. A similar pattern was found experiment on an experimental neural pacemaker perfused with solution whose extracellular calcium concentration ([Ca2+]o) lower than normal level which firing period 1 spiking. results verified existence implied its CR mechanism. In addition, distinction between...