A5049586043- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Lipid Membrane Structure and Behavior
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Adenosine and Purinergic Signaling
- Cellular transport and secretion
- Photoreceptor and optogenetics research
- Axon Guidance and Neuronal Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Pain Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Protein Kinase Regulation and GTPase Signaling
- Electrochemical Analysis and Applications
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Neurobiology and Insect Physiology Research
- Biochemical effects in animals
University of Castilla-La Mancha
2016-2025
Institut de Biomedicina de la Universitat de Barcelona
2024
University of the Basque Country
2019
Hokkaido University
2009
University of Geneva
2007
University Hospital of Geneva
2007
Japan Science and Technology Agency
2006
National Institute for Physiological Sciences
2003-2006
University of Oxford
1997-2003
University of Freiburg
2003
Abstract Ionotropic and metabotropic (mGluR1a) glutamate receptors were reported to be segregated from each other within the postsynaptic membrane at individual synapses. In order establish whether this pattern of distribution applies hippocampal principal cells receptors, mGluR1a/b/c mGluR5 subtypes localized by immunocytochemistry. Principal in all fields reactive for mGluR5, strata oriens radiatum CA1 area being most strongly immunolabelled. Labelling mGluR1b/c was strongest on some...
The functional role of heteromers G-protein-coupled receptors is a matter debate. In the present study, we demonstrate that heteromerization adenosine A 1 (A Rs) and 2A allows to exert fine-tuning modulation glutamatergic neurotransmission. By means coimmunoprecipitation, bioluminescence time-resolved fluorescence resonance energy transfer techniques, showed existence R–A R in cell surface cotransfected cells. Immunogold detection coimmunoprecipitation experiments indicated are colocalized...
Neuropathic pain results from damage to the peripheral sensory nervous system, which may have a number of causes. The calcium channel subunit alpha(2)delta-1 is upregulated in dorsal root ganglion (DRG) neurons several animal models neuropathic pain, and this causally related onset allodynia, non-noxious stimulus becomes painful. therapeutic drugs gabapentin pregabalin (PGB), are both alpha(2)delta ligands, antiallodynic effects, but their mechanism action has remained elusive. To...
The activation of metabotropic glutamate receptors (mGluRs) leads to long-term depression (mGluR-LTD) at many synapses the brain. induction mGluR-LTD is well characterized, whereas mechanisms underlying its expression remain largely elusive. in ventral tegmental area (VTA) efficiently reverses cocaine-induced strengthening excitatory inputs onto dopamine neurons. We show that expressed by an exchange GluR2-lacking AMPA for GluR2-containing with a lower single-channel conductance. synaptic...
Abstract G protein‐coupled receptors are known to form homo‐ and heteromers at the plasma membrane, but stoichiometry of these receptor oligomers relatively unknown. Here, by using bimolecular fluorescence complementation, we visualized for first time occurrence heterodimers metabotropic glutamate mGlu 5 (mGlu R) dopamine D 2 (D in living cells. Furthermore, combination complementation bioluminescence resonance energy transfer techniques, as well sequential technique, allowed us detect...
Metabotropic GABA B receptors mediate slow inhibitory effects presynaptically and postsynaptically. Using preembedding immunohistochemical methods combined with quantitative analysis of receptor subunit immunoreactivity, this study provides a detailed description the cellular subcellular localization B1a/b B2 in rat hippocampus. At light microscopic level, an overlapping distribution was revealed dendritic layers In addition, expression found somata CA1 pyramidal cells subset GABAergic...
Neuronal G-protein-gated potassium (GIRK) channels mediate the inhibitory effects of many neurotransmitters. Although overlapping distribution GIRK subunits suggests that channel composition varies in CNS, little direct evidence supports existence structural or functional diversity neuronal repertoire. Here we show linked to GABA B receptors differed two neuron populations. In substantia nigra, GIRK2 was principal subunit, and it found primarily dendrites neurons nigra pars compacta (SNc)....