A5034027677- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Marine animal studies overview
- Underwater Acoustics Research
- Axon Guidance and Neuronal Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Developmental Biology and Gene Regulation
- HER2/EGFR in Cancer Research
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Underwater Vehicles and Communication Systems
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Animal Vocal Communication and Behavior
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Protein Tyrosine Phosphatases
University of Basel
2015-2025
Scripps Institution of Oceanography
2011-2023
University of California, San Diego
2011-2023
Scripps (United States)
2011
Czech Academy of Sciences, Institute of Physiology
2009
University of Balochistan
2006
Novartis (Switzerland)
2004
Novartis Institutes for BioMedical Research
2004
Yale University
2003
University Hospital of Zurich
2002
Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development. To examine later phenotypes, we rescued mutant mice expressing under a cardiac-specific myosin promoter. Rescued reach adulthood and are fertile. However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly lactation is defective. also display aberrant nerve architecture increased...
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled (GPCR) that nonselectively activated by endogenous metabolites of amino acids. TAAR1 considered promising drug target for the treatment psychiatric and neurodegenerative disorders. However, no selective ligand to identify TAAR1-specific signaling mechanisms available yet. Here we report antagonist, EPPTB, characterize its physiological effects at dopamine (DA) neurons ventral tegmental area (VTA). We show EPPTB prevents...
GABA B receptors mediate slow synaptic inhibition in the nervous system. In transfected cells, functional are usually only observed after coexpression of B(1) and B(2) subunits, which established concept heteromerization for G-protein-coupled receptors. heteromeric receptor, is responsible binding GABA, whereas necessary surface trafficking G-protein coupling. Consistent with these vitro observations, subunit also essential all signaling vivo . Mice lacking do not exhibit detectable...
Abstract Triggering of the T cell antigen receptor/CD3 (TcR/CD3) complex leads to rapid tyrosine phosphorylation regulatory proteins that participate in initiating activation and proliferation. This signal transduction event requires presence TcR/CD3‐associated protein kinase p59 fyn . There is also evidence CD45 phosphotyrosine phosphatase involved TcR/CD3 signalling. We show here by capping experiments using double indirect immunofluorescence techniques receptor intracellular specifically...
GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain GBRs. Of three interacting proteins, selectively genetic loss APP impaired GBR-mediated inhibition axonal GBR expression. Proteomic functional analyses revealed associates JIP calsyntenin proteins link APP/GBR complex...
Src family protein tyrosine kinases (PTKs) play an essential role in antigen receptor-initiated lymphocyte activation. Their activity is largely regulated by a negative regulatory which substrate for the activating action of CD45 phosphotyrosine phosphatase (PTPase) or, conversely, suppressing cytosolic p50csk PTK. Here we report that was phosphorylated on two residues, one them identified as Tyr-1193. This residue not T-cell PTKs p56lck and p59fyn. Tyr-1193 intact T cells, phosphorylation...
Metabotropic GABAB receptors predominantly function as heterodimers of GABAB(1) and GABAB(2) subunits, but can also form functional in the absence GABAB(2). Mice lacking subunit have altered behavioural responses tests for anxiety depression. In these studies, we investigated depression GABAB(2)-deficient mice. We compared effects directly with that genetic deletion receptor subunit. Both mice were found to be more anxious than wild type light–dark box paradigm. contrast, exhibited an...
GABAB receptors are the G-protein-coupled for GABA, main inhibitory neurotransmitter in brain. abundant on dendritic spines, where they dampen postsynaptic excitability and inhibit Ca2+ influx through NMDA when activated by spillover of GABA from neighboring GABAergic terminals. Here, we show that an excitatory signaling cascade enables spines to counteract this GABAB-mediated inhibition. We found application cultured hippocampal neurons promotes dynamin-dependent endocytosis receptors....
Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and progeny express metabotropic GABAB receptors. Pharmacological inhibition receptors stimulated NSC proliferation genetic deletion GABAB1 subunits increased differentiation neuroblasts in vivo. Cell-specific conditional supports...
Significance Stress can increase susceptibility to developing psychiatric disorders, including depression. Understanding the neurobiological mechanisms underlying stress resilience and is key identifying novel targets for development of more effective treatments stress-related disorders. Here we show that specific isoforms GABA B receptor subunits differentially regulate resilience. Specifically, B(1a) −/− mice are susceptible whereas B(1b) resilient stress-induced anhedonia psychosocial...