A5048007911- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Zebrafish Biomedical Research Applications
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Blood properties and coagulation
- Photoreceptor and optogenetics research
- Autism Spectrum Disorder Research
- High Altitude and Hypoxia
- Advanced Memory and Neural Computing
- Physiological and biochemical adaptations
- Electron Spin Resonance Studies
- Phonetics and Phonology Research
- Spaceflight effects on biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Ion channel regulation and function
- Retinal Development and Disorders
- Molecular Sensors and Ion Detection
- Coral and Marine Ecosystems Studies
- Syntax, Semantics, Linguistic Variation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neurogenesis and neuroplasticity mechanisms
California State University, Fullerton
2019-2022
University of California, Los Angeles
2003-2017
University of North Carolina at Chapel Hill
2008-2011
Emporia State University
2000
SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of excitatory synapses. Small microdeletions and point mutations have been identified small subgroup individuals with autism spectrum disorder (ASD) intellectual disability. also plays key role chromosome 22q13.3 microdeletion syndrome (Phelan–McDermid syndrome), which includes ASD cognitive dysfunction as major clinical features. To evaluate Shank3 vivo , we disrupted isoforms gene mice by deleting exons...
Long-term memory (LTM) is believed to be stored in the brain as changes synaptic connections. Here, we show that LTM storage and change can dissociated. Cocultures of Aplysia sensory motor neurons were trained with spaced pulses serotonin, which induces long-term facilitation. Serotonin (5HT) triggered growth new presynaptic varicosities, a mechanism sensitization. Following 5HT training, two antimnemonic treatments—reconsolidation blockade inhibition PKM—caused number varicosities revert...
Subunit composition of N-methyl-D-aspartate–type glutamate receptors (NMDARs) dictates their function, yet the ontogenic profiles human NMDAR subunits from gestation to adulthood have not been determined. We examined mRNA and protein development in dorsolateral prefrontal cortex (DLPFC), an area which NMDARs are critical for higher cognitive processing hypofunction is hypothesized schizophrenia. Using quantitative reverse transcriptase–polymerase chain reaction western blotting, we found NR1...
The zebrafish larva has been a valuable model system for genetic and molecular studies of development. More recently, biologists have begun to exploit the surprisingly rich behavioral repertoire larvae investigate behavior. One prominent behavior exhibited by early in development is rapid escape reflex (the C-start). This mediated relatively simple neural circuit, therefore an attractive neurobiological investigations forms learning memory. Here, we describe two short-lived habituation...
Previously, we reported that long-term memory (LTM) in Aplysia can be reinstated by truncated (partial) training following its disruption reconsolidation blockade and inhibition of PKM (Chen et al., 2014). Here, report LTM induced partial after original consolidation protein synthesis (PSI) begun shortly training. But when PSI occurs during training, cannot subsequently establish LTM. Furthermore, find DNA methyltransferase (DNMT), whether or afterwards, blocks prevents subsequent induction...
NMDA receptors (NMDARs) are required for experience-driven plasticity during formative periods of brain development and critical neurotransmission throughout postnatal life. Most NMDAR functions have been ascribed to postsynaptic sites action, but there is now an appreciation that presynaptic NMDARs (preNMDARs) can modulate neurotransmitter release in many regions, including the neocortex. Despite these advances, cellular mechanisms by which preNMDARs affect largely unknown. Here we...
The suggestion that NMDA receptor (NMDAR)-dependent plasticity is subunit specific, with NR2B-types required for long-term depression (LTD) and NR2A-types critical the induction of potentiation (LTP), has generated much attention considerable debate. By investigating suggested subunit-specific roles NMDARs in mouse primary visual cortex over development, we report several important findings clarify NMDAR subtypes synaptic plasticity. We observed LTD was not attenuated by application...
Zebrafish larvae have several biological features that make them useful for cellular investigations of the mechanisms underlying learning and memory. Of particular interest in this regard is a rapid escape, or startle, reflex possessed by zebrafish larvae; reflex, C-start, mediated relatively simple neuronal circuit exhibits habituation, non-associative form learning. Here we demonstrate habituation C-start to touch resembles previously reported induced auditory vibrational stimuli. We also...
Abstract Because of their ex utero development, relatively simple nervous system, translucency, and availability tools to investigate neural function, larval zebrafish are an exceptional model for understanding neurodevelopmental disorders the consequences environmental toxins. Furthermore, early in larvae easily absorb chemicals from water, a significant advantage over methods required expose developing organisms chemical agents . Bisphenol A (BPA) BPA analogs ubiquitous toxins with known...
Musk turtles (Sternotherus odoratus) can survive at least 150 days of submergence in normoxic water 3°C, during which time there are large increases packed cell volume (PCV). We investigated the effects 3°C on blood viscosity musk from northern (Massachusetts) and southern (Alabama) locales. Blood was collected air-breathing after 20, 50, 100, 3°C. Hematological responses to were similar two groups, therefore results combined. Packed increased steadily above that controls submergence....
Larval zebrafish possess a number of molecular and genetic advantages for rigorous biological analyses learning memory. These have motivated the search novel forms memory in these animals that can be exploited understanding cellular bases vertebrate formation consolidation. Here, we report new form behavioral sensitization larvae is elicited by an aversive chemical stimulus [allyl isothiocyanate (AITC)] persists ≥30 min. This expressed as enhanced locomotion thigmotaxis, well elevated heart...