A5081010075- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Biomedical and Engineering Education
- Health and Medical Research Impacts
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Advanced Memory and Neural Computing
- Memory and Neural Mechanisms
- Photochromic and Fluorescence Chemistry
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- CCD and CMOS Imaging Sensors
- Sleep and Wakefulness Research
University of North Carolina at Chapel Hill
2005-2014
University of Washington
2004-2009
NMDA receptor (NMDAR) activation is required for many forms of learning and memory as well sensory system receptive field plasticity, yet the relative contribution presynaptic postsynaptic NMDARs over cortical development remains unknown. Here we demonstrate a rapid developmental loss functional in neocortex. Presynaptic enhance neurotransmitter release at synapses onto visual cortex pyramidal cells young mice [before postnatal day 20 (P20)], but they have no apparent effect after onset...
Spontaneous [Ca2+]i transients were measured in the mouse neocortex from embryonic day 16 (E16) to postnatal 6 (P6). On of birth (P0), cortical neurones generated widespread, highly synchronous over large areas. average, 52% participated these transients, and 20% slices, an average 80% participated. These blocked by TTX nifedipine, indicating that they resulted Ca2+ influx during electrical activity, occurred at a mean frequency 0.91 min(-1). The occurrence this activity was centred P0: E16...
Use-dependent modifications of synapses have been well described in the developing visual cortex, but ability for experience to modify adult cortex is poorly understood. We found that 10 d late-onset deprivation modifies both presynaptic and postsynaptic elements at layer 4→2/3 connection mice, these changes differ from those observed juveniles. Although juvenile mice subunit composition increases current duration synaptic NMDA receptors (NMDARs), no such effect between 4 2/3 pyramidal...
Abstract The second messenger cyclic guanosine monophosphate (cGMP) plays many roles during nervous system development. Consequently, cGMP production shows complex patterns of regulation throughout early Elevated glutamate levels are known to increase in the mature system. A number clinical conditions including ischemia and perinatal asphyxia can result elevated developing brain. To investigate effects on cortex we exposed mouse brain slices or N ‐methyl D ‐aspartate (NMDA). We find that at...