A5050722237- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Autism Spectrum Disorder Research
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Advanced Malware Detection Techniques
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Data Visualization and Analytics
- Cell Image Analysis Techniques
- Nerve injury and regeneration
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Photochromic and Fluorescence Chemistry
- Transcranial Magnetic Stimulation Studies
University of California, Berkeley
2016-2025
Berkeley College
2019-2025
Neuroscience Institute
2024
University of Haifa
2020
Google (United States)
2017
University of California, San Francisco
1998-2014
University of Minnesota System
2014
University at Albany, State University of New York
2014
Salk Institute for Biological Studies
2013
State University of New York
2013
Many cortical synapses exhibit spike timing-dependent plasticity (STDP) in which the precise timing of presynaptic and postsynaptic spikes induces synaptic strengthening [long-term potentiation (LTP)] or weakening depression (LTD)]. Standard models posit a single, postsynaptic, NMDA receptor-based coincidence detector for LTP LTD components STDP. We show instead that STDP at layer 4 to 2/3 somatosensory (S1) cortex involves separate calcium sources detection mechanisms LTD. showed classical...
We summarize here the results presented and subsequent discussion from meeting on Integrating Hebbian Homeostatic Plasticity at Royal Society in April 2016. first outline major themes meeting. next provide a synopsis of outstanding questions that emerged end finally suggest potential directions research we believe are most promising to develop an understanding how these two forms plasticity interact facilitate functional changes brain.This article is part themed issue 'Integrating...
Thalamocortical synaptic transmission in the rat's primary somatosensory (S1) cortex is modified by sensory experience during a critical period early life. Despite importance of such plasticity for maturation thalamocortical circuits, basis this unknown. Here, we review evidence suggesting that long-term potentiation and depression (LTP LTD) may be involved plasticity. In an vitro slice preparation, responses exhibit N-methyl-D-aspartate (NMDA) receptor-dependent LTP LTD developmental...
Rats discriminate surface textures using their whiskers (vibrissae), but how extract texture information, and this information is encoded by the brain, are not known. In resonance model, whisker motion across different excites mechanical in distinct subsets of whiskers, due to variation frequency, which varies with length. Texture therefore spatial pattern activated whiskers. competing kinetic signature excite equally instead, characteristic, nonuniform temporal patterns motion. We tested...
Presynaptic NMDA receptors (NMDARs) modulate release and plasticity at many glutamatergic synapses, but the specificity of their expression across synapse classes has not been examined. We found that non-postsynaptic, likely presynaptic NR2B-containing NMDARs enhanced AMPA receptor-mediated synaptic transmission layer 4 (L4) to L2/3 (L4–L2/3) synapses in juvenile rat barrel cortex. This modulation was apparent room temperature when were activated by elevation extracellular glutamate or...
Long-term expression of optogenetic proteins including channelrhodopsin-2 (ChR2) is widely used to study neural circuit function, but whether ChR2 itself perturbs circuits not known. We expressed a common construct, CAG::ChR2(H134R)-EYFP-WPRE, in L2/3 pyramidal cells rat somatosensory cortex via utero DNA electroporation. ChR2-EYFP, histology revealed abnormal morphology and targeting ChR2-EYFP expressing axons, beginning at postnatal day (P) 33 increasing with age. Axonal abnormalities...
Layer (L)2 is a major output of primary sensory cortex that exhibits very sparse spiking, but the structure representation in L2 not well understood. We combined two-photon calcium imaging with deflection many whiskers to map whisker receptive fields, characterize coding, and quantitatively define point mouse somatosensory cortex. Neurons within column-sized field showed surprisingly heterogeneous, salt-and-pepper tuning different whiskers. Single elicited low-probability spikes highly...
Whisker deprivation weakens excitatory layer 4 (L4) inputs to L2/3 pyramidal cells in rat primary somatosensory (S1) cortex, which is likely contribute whisker map plasticity. This weakening has been proposed represent long-term depression (LTD) induced by sensory vivo . Here, we studied the synaptic expression mechanisms for deprivation-induced of L4-L2/3 and assessed its similarity LTD, known be expressed presynaptically at synapses. increased paired pulse ratio synapses slowed...
Significance Neurons exhibit distinct homeostatic and Hebbian forms of plasticity that stabilize firing rate adaptively alter synaptic input patterns, respectively. How these mechanisms are recruited in response to sensory experience vivo is unclear. We studied rodent somatosensory cortex, where the neural map whiskers changes reflect statistics but only after a prominent initial delay. By recording excitation inhibition vivo, we found delay reflects not lack rapid homeostasis, which...