A5013589294- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Prenatal Substance Exposure Effects
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Zebrafish Biomedical Research Applications
- Autism Spectrum Disorder Research
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Health and Development
- Neonatal and fetal brain pathology
- Child Nutrition and Feeding Issues
- Tryptophan and brain disorders
- Environmental Toxicology and Ecotoxicology
- Infant Development and Preterm Care
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Down syndrome and intellectual disability research
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Receptor Mechanisms and Signaling
Harvard University
2023-2025
Massachusetts General Hospital
2023-2025
University of Maryland, Baltimore
2017-2024
Harvard Stem Cell Institute
2023-2024
Broad Institute
2023-2024
University of California, Los Angeles
2022
California State University, San Bernardino
2016-2020
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined behavioral, morphological, and biochemical effects of defeat stress model depression on hippocampal dendritic spines within CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to episodes 10 consecutive days....
Abstract Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise incidence of neonatal withdrawal syndrome (NOWS) and lifelong neurobehavioral deficits that result from perinatal exposure. There are few preclinical models accurately recapitulate human drug exposure focus on fentanyl, potent synthetic leading driver epidemic. To investigate consequences exposure, we administered fentanyl to mouse dams their drinking water throughout...
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae afflicting adolescents exposed to opioids in womb. A translationally relevant and developmentally accurate preclinical model is needed understand behavioral, circuit, network, molecular abnormalities resulting from this exposure. By employing a novel perinatal fentanyl exposure, our data reveal that has several dose-dependent, developmental consequences somatosensory function behavior. Newborn male female mice...
<title>Abstract</title> The hippocampus forms memories of our experiences by registering processed sensory information in coactive populations excitatory principal cells or ensembles. Fast-spiking parvalbumin-expressing inhibitory neurons (PV INs) the dentate gyrus (DG)-CA3/CA2 circuit contribute to memory encoding exerting precise temporal control cell activity through mossy fiber-dependent feed-forward inhibition. PV INs respond input-specific coordinating changes their intrinsic...
Adult-born dentate granule cells (abDGCs) contribute to hippocampal gyrus (DG)-CA3/CA2 circuit functions in memory encoding, retrieval and consolidation. Heightened synaptic structural plasticity of immature abDGCs is thought govern their distinct contributions network mechanisms hippocampal-dependent operations. Protracted maturation or neoteny higher mammals hypothesized offset decline adult neurogenesis by expanding the capacity for underlying different Here, we provide evidence this...
<title>Abstract</title> Adult-born dentate granule cells (abDGCs) contribute to hippocampal gyrus (DG)-CA3/CA2 circuit functions in memory encoding, retrieval and consolidation. Heightened synaptic structural plasticity of immature abDGCs is thought govern their distinct contributions network mechanisms hippocampal-dependent operations. Protracted maturation or neoteny higher mammals hypothesized offset decline adult neurogenesis by expanding the capacity for underlying different Here, we...
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae afflicting adolescents exposed to opioids in womb. A translationally relevant and developmentally accurate preclinical model is needed understand behavioral, circuit, network, molecular abnormalities resulting from this exposure. By employing a novel perinatal fentanyl exposure, our data reveal that has several dose-dependent, developmental consequences somatosensory function behavior. Newborn male female mice...
Heterozygous mutations in the dual-specificity tyrosine phosphorylation-regulated kinase 1a (Dyrk1a) gene define a syndromic form of autism spectrum disorder. The synaptic and circuit mechanisms mediating DYRK1A functions social cognition are unclear. Here, we identify experience-sensitive mechanism hippocampal mossy fiber-parvalbumin interneuron (PV IN) synapses by which recruits feedforward inhibition CA3 CA2 to promote recognition. We employ genetic epistasis logic cytoskeletal protein,...
The opioid epidemic is a rapidly evolving societal issue driven, in part, by surge synthetic use. A rise fentanyl use among pregnant women has led to 40-fold increase the number of perinatally-exposed infants past decade. These children are more likely develop mood-related and somatosensory-related conditions later life, suggesting that may permanently alter neural development. Here, we examined behavioral synaptic consequences perinatal exposure adolescent male female C57BL/6J mice assessed...
The potency of the synthetic opioid fentanyl and its increased clinical availability has led to rapid escalation use in general population, recreational exposure, subsequently opioid-related overdoses. wide-spread has, consequently, incidence utero exposure drug, but long-term effects this type developmental are not yet understood. Opioid also been linked reduced mitochondrial copy number blood populations, link between peripheral biomarker genetic or functional changes reward-related brain...
SUMMARY Adaptive regulation of feeding depends on linkage internal states and food outcomes with contextual cues. Human brain imaging has identified dysregulation a hippocampal-lateral hypothalamic area (LHA) network in binge eating, but mechanistic instantiation underlying cell-types circuitry is lacking. Here, we identify an evolutionary conserved discrete Prodynorphin ( Pdyn )-expressing subpopulation Somatostatin Sst inhibitory neurons the dorsolateral septum (DLS) that receives...
Opioid use by pregnant women results in neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobehavioral deficits including language impairments. Animal models of NOWS show impaired performance a two-tone auditory discrimination task, suggesting abnormalities sensory processing the cortex. To investigate consequences perinatal exposure on cortex circuits, we administered fentanyl to mouse dams their drinking water throughout gestation until litters were weaned at postnatal day (P)21....
Larval zebrafish possess a number of molecular and genetic advantages for rigorous biological analyses learning memory. These have motivated the search novel forms memory in these animals that can be exploited understanding cellular bases vertebrate formation consolidation. Here, we report new form behavioral sensitization larvae is elicited by an aversive chemical stimulus [allyl isothiocyanate (AITC)] persists ≥30 min. This expressed as enhanced locomotion thigmotaxis, well elevated heart...
Abstract Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise incidence of neonatal withdrawal syndrome (NOWS), and lifelong neurobehavioral deficits that result from perinatal exposure. There are few preclinical models accurately recapitulate human drug exposure, focus on fentanyl, potent synthetic leading driver epidemic. To investigate consequences we administered fentanyl to mouse dams their drinking water throughout...
Abstract Women are disproportionately affected by chronic pain compared to men. While societal and environmental factors contribute this disparity, sex-based biological differences in the processing of also believed play significant roles. The central lateral nucleus amygdala (CeLC) is a key region for emotional-affective dimension pain, prime target exploring sex since recent study demonstrated CGRP actions region. Inputs CeLC from parabrachial (PB) causal role aversive processing, release...
Women are disproportionately affected by chronic pain compared with men. While societal and environmental factors contribute to this disparity, sex-based biological differences in the processing of also believed play significant roles. The central lateral nucleus amygdala (CeLC) is a key region for emotional-affective dimension pain, prime target exploring sex since recent study demonstrated CGRP actions region. Inputs CeLC from parabrachial (PB) causal role aversive release both glutamate...
ABSTRACT Use of the synthetic opioid fentanyl increased ∼300% in last decade, including among women reproductive ages. Adverse neonatal outcomes and long-term behavioral disruptions are associated with perinatal exposure. Our previous work demonstrated that exposed mice displayed enhanced negative affect somatosensory circuit during adolescence. However, little is known about molecular adaptations across brain regions underlie these outcomes. We performed RNA-sequencing three reward two...
Heterozygous mutations in the Dual specificity tyrosine-phosphorylation-regulated kinase 1a Dyrk1a gene define a syndromic form of Autism Spectrum Disorder. The synaptic and circuit mechanisms mediating functions social cognition are unclear. Here, we identify experience-sensitive mechanism hippocampal mossy fiber-parvalbumin interneuron (PV IN) synapses by which recruits feedforward inhibition CA3 CA2 to promote recognition. We employ genetic epistasis logic cytoskeletal protein, Ablim3, as...
Heterozygous mutations in the Dual specificity tyrosine-phosphorylation-regulated kinase 1a Dyrk1a gene define a syndromic form of Autism Spectrum Disorder. The synaptic and circuit mechanisms mediating functions social cognition are unclear. Here, we identify experience-sensitive mechanism hippocampal mossy fiber-parvalbumin interneuron (PV IN) synapses by which recruits feed-forward inhibition CA3 CA2 to promote recognition. We employ genetic epistasis logic cytoskeletal protein, Ablim3,...
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae afflicting adolescents exposed to opioids in womb. A translationally relevant and developmentally accurate preclinical model is needed understand behavioral, circuit, network, molecular abnormalities resulting from this exposure. By employing a novel perinatal fentanyl exposure, our data reveal that has several dose-dependent, developmental consequences somatosensory function behavior. Newborn male female mice...