A5086067811- Tryptophan and brain disorders
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Estrogen and related hormone effects
- Nicotinic Acetylcholine Receptors Study
- Menopause: Health Impacts and Treatments
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- X-ray Diffraction in Crystallography
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Crystallization and Solubility Studies
- Infant Health and Development
- Axon Guidance and Neuronal Signaling
- Amyotrophic Lateral Sclerosis Research
- Sex and Gender in Healthcare
- Memory and Neural Mechanisms
- Pharmacological Effects and Assays
- Genetics, Aging, and Longevity in Model Organisms
University of Wisconsin–Milwaukee
2023-2025
University of Maryland, Baltimore
2016-2024
University of Cyprus
2022-2024
VA Maryland Health Care System
2022
National Institute on Aging
2018-2021
National Institutes of Health
2018-2021
National Institute of Mental Health
2018-2021
Institute on Aging
2018-2021
National Center for Advancing Translational Sciences
2018-2021
University of Surrey
2013-2018
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the relevance of this pharmacology to its rapid (within hours administration) antidepressant actions, which depend on mechanisms convergent with strengthening excitatory synapses, unclear. Activation synaptic NMDARs necessary for induction canonical long-term potentiation (LTP) leading sustained expression increased strength. We tested hypothesis that effects requires NMDAR activation, by using behavioral...
Estradiol, the most potent and prevalent member of estrogen class steroid hormones is expressed in both sexes. Functioning as a neuroactive steroid, it plays crucial role modulating neurotransmitter systems affecting neuronal circuits brain functions including learning memory, reward sexual behaviors. These encompass serotonergic, dopaminergic, glutamatergic signaling pathways. Consequently, this review examines pivotal estradiol its receptors regulation these brain. Through comprehensive...
Significance Despite available medications for depression, currently approved antidepressants take months to exert therapeutic effects, and ∼30% of patients remain treatment resistant. In contrast, a single subanesthetic dose ketamine exerts rapid (within hours) sustained antidepressant actions. Preclinical studies indicate that the metabolite ( 2R , 6R )-hydroxynorketamine [( )-HNK] is rapid-acting candidate with limited adverse effects compared ketamine. Using behavioral, genetic,...
New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts actions in depressed patients but also side effects complicate its clinical utility. Ketamine promotes excitatory synaptic strength, likely by producing high-frequency correlated activity mood-relevant regions the forebrain. Negative allosteric modulators GABA-A receptors containing α5 subunits (α5 GABA-NAMs) should promote electroencephalogram (EEG)...
Significance Animal models of human diseases provide important tools for mechanistic and preclinical investigations. Mutations in several genes cause ALS. One such gene is ubiquilin 2 ( UBQLN2 ), mutations which dominant inheritance ALS with frontotemporal dementia (ALS–FTD). Several rodent carrying have been described, but none develop motor neuron disease. We describe two transgenic (Tg) mouse ALS–FTD different mutations. Both cognitive deficits, classic TAR-DNA binding protein 43 (TDP-43)...
Background and Purpose ( R )‐Ketamine (arketamine) may have utility as a rapidly acting antidepressant. While )‐ketamine has lower potency than R,S to inhibit NMDA receptors in vitro, the extent which shares receptor‐mediated adverse effects of vivo not been fully characterised. Furthermore, is metabolised 2R,6R )‐hydroxynorketamine (HNK), contribute its antidepressant‐relevant actions. Experimental Approach Using mice, we compared with deuterated form drug (6,6‐dideutero‐( )‐ketamine, )‐d 2...
Abstract Histone modifications commonly integrate environmental cues with cellular metabolic outputs by affecting gene expression. However, chromatin such as acetylation do not always correlate transcription, pointing towards an alternative role of histone in metabolism. Using approach that integrates mass spectrometry-based modification mapping and metabolomics stable isotope tracers, we demonstrate elevated lipids acetyltransferase-depleted hepatocytes result from carbon atoms derived...
Background The hippocampus, vital for memory and learning, is among the first brain regions affected in Alzheimer’s Disease (AD) exhibits adult neurogenesis. Women face twice risk of developing AD compare to men, making it crucial understand sex differences hippocampal function comprehending susceptibility. Methods We conducted a comprehensive analysis bulk mRNA postmortem samples from whole hippocampus (GSE48350, GSE5281) its CA1 CA3 subfields (GSE29378). Our aim was perform comparative...
Opioid use disorder (OUD) is a pressing public health concern marked by frequent relapse during periods of abstinence, perpetuated negative affective states. Classical antidepressants or the currently prescribed opioid pharmacotherapies have limited efficacy to reverse affect prevent relapse. Using mouse models, we investigated effects ketamine's metabolite (2R,6R)-hydroxynorketamine (HNK) on reversing conditioning sub-effective doses morphine in stress-susceptible mice, preventing...
Abstract The key problem for the treatment of drug addiction is relapse to use after abstinence that can be triggered by drug‐associated cues, re‐exposure itself and stress. Understanding neurobiological mechanisms underlying essential in order develop effective pharmacotherapies its prevention. Given evidence implicating metabotropic glutamate receptor 5 ( mGlu R ), μ‐opioid MOPr κ‐opioid ΚOPr ) oxytocin OTR systems cocaine relapse, our aim was assess modulation these receptors using a...