A5065697207- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Electroconvulsive Therapy Studies
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Photoreceptor and optogenetics research
University of Maryland, Baltimore
2015-2025
National Institute of Mental Health
2024
National Institutes of Health
2024
University of Arkansas for Medical Sciences
2022
Sheppard and Enoch Pratt Hospital
2021
University of Maryland Medical Center
2021
Czech Academy of Sciences, Institute of Physiology
2013
Cornell University
2010-2012
Chronic stress promotes depression, but how it disrupts cognition and mood remains unknown. causes atrophy of pyramidal cell dendrites in the hippocampus cortex human animal models, a depressive-like behavioral state. We now test hypothesis that excitatory temporoammonic (TA) synapses distal CA1 cells rats are altered by chronic unpredictable (CUS) restored antidepressant treatment, conjunction with consequences CUS. observed decrease AMPAR-mediated excitation at TA-CA1 synapses, not...
Chronic stress is thought to impart risk for depression via alterations in brain structure and function, but contributions of specific mediators generating these changes remain unclear. We test the hypothesis that stress-induced increases corticosterone (CORT), primary rodent glucocorticoid, are key mediator depressive-like behavioral synaptic dysfunction rat hippocampus. In rats, we correlated cognitive affective tasks (spatial memory consolidation, anhedonia, neohypophagia) with impaired...
Significance Animal models of human diseases provide important tools for mechanistic and preclinical investigations. Mutations in several genes cause ALS. One such gene is ubiquilin 2 ( UBQLN2 ), mutations which dominant inheritance ALS with frontotemporal dementia (ALS–FTD). Several rodent carrying have been described, but none develop motor neuron disease. We describe two transgenic (Tg) mouse ALS–FTD different mutations. Both cognitive deficits, classic TAR-DNA binding protein 43 (TDP-43)...
Abstract Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer’s disease (AD). Both SZ and AD have white matter abnormalities cognitive deficits as core features. We hypothesized that aging in patients may be the development of cerebral deficit patterns similar to those observed AD. identified replicated aging-related increases similarity between The “regional vulnerability index” (RVI) was significantly higher compared healthy controls...
Stressful life events are known as risk factors for depression, though there is considerable heterogeneity in how people respond to stress. Previous studies have found an association between experience of stressful and the personality trait openness experience, which itself has been associated with intelligence, creativity, risk-taking, other clinically relevant behaviors. In this study we explore a potential developmental pathway depression Amish Mennonites, rural populations high degree...
Schizophrenia spectrum disorder (SSD) is a chronic neuropsychiatric illness accompanied by significant brain structural and functional abnormalities higher rate of cardio- cerebrovascular comorbidities. We hypothesized that genetic environmental risk factors led to SSD act throughout the body demonstrated association between lower integrity peripheral vascular endothelium white matter (WM) microstructure. Microvascular endothelial function was evaluated using brachial artery post-occlusive...
Primary central nervous system lymphoma (PCNSL) may rarely be preceded by "sentinel demyelination," a pathologic entity characterized histologically confirmed demyelinating inflammatory brain lesions that mimic multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM). Interpreting the overlapping radiologic and clinical characteristics associated with each of these conditions—contrast-enhancing demyelination white matter relapsing remitting steroid-responsive symptoms...
Abstract Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white integrity. We proposed the regional vulnerability index (RVI) to translate results Enhancing Neuro Imaging Genetics Meta‐Analysis studies individual level. calculated RVIs for cortical, subcortical, measurements a multimodality RVI. evaluated RVI as measure sensitive schizophrenia‐specific neuroanatomical symptoms studied timeline...
Decreased cerebral blood flow (CBF) may be an important mechanism associated with depression. In this study we aimed to determine if the association of CBF and depression is dependent on current level or tendency experience over time (trait depression), influenced by depression-related factors such as stressful life experiences antidepressant medication use. was measured in 254 participants from Amish Connectome Project (age 18–76, 99 men 154 women) using arterial spin labeling. All...
Neuromodulators modify network output by altering neuronal firing properties and synaptic strength at multiple sites; however, the functional importance of each site is often unclear. We determined monoamine modulation a single synapse for regulation cycle frequency in oscillatory pyloric lobster. The pacemaker kernel receives only one chemical feedback, an inhibitory from lateral (LP) neuron to dilator (PD) neurons, which can limit frequency. measured effects dopamine (DA), octopamine...
Abstract Insufficient or lack of response to antipsychotic medications in some patients with schizophrenia is a major challenge psychiatry, but the underlying mechanisms remain unclear. Two seemingly unrelated observations, cerebral white matter and N-methyl-D-aspartate receptor (NMDAR) hypofunction, have been linked treatment-resistant (TRS). As NMDARs are critical axonal myelination signal transduction, we hypothesized that NMDAR antibody (Ab), when present schizophrenia, may impair...
Abstract Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar (BD), and schizophrenia spectrum (SSD) elevate accelerated brain aging risks. Cardio‐metabolic disorders (CMD) are common comorbidities in SMI negatively impact health. We validated a linear quantile regression index (QRI) approach against the machine learning “BrainAge” an independent SSD cohort ( N = 206). tested direct additive effects of CMD on 1,618 (604 M/1,014 F, average age 63.53 ± 7.38)...
Abstract Background and Hypothesis Mounting evidence supports cerebrovascular contributions to schizophrenia spectrum disorder (SSD) but with unknown mechanisms. The blood–brain barrier (BBB) is at the nexus of neural-vascular exchanges, tasked regulating cerebral homeostasis. BBB abnormalities in SSD, if any, are likely more subtle compared typical neurological insults imaging measures that assess large molecule leakage major events may not be sensitive enough directly examine SSD. Study...
Reduced cortical gray matter integrity and cognitive abilities are among core deficits in schizophrenia. We hypothesized that higher allostatic load (AL) accounts for exposure to chronic stress is a contributor structural One hundred sixty-seven schizophrenia patients who were on average with normal weight, systolic, diastolic blood pressure 72 healthy controls enrolled the study. Group differences subclinical cardiovascular, metabolic, immune, neuroendocrine biological markers as indexed by...
Summary An important measure of brain health is the integrity white matter connectivity structures that link regions. Studies have found an association between poorer sleep quality and decreased integrity. Stress among strongest predictors quality. This study aimed to evaluate test if relationship persisted after accounting for stress. White microstructures were measured by diffusion tensor imaging in a population Old Order Amish/Mennonite ( N = 240). Sleep was determined Pittsburgh Quality...
Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in wide range neuropsychiatric disorders. Computed from resting-state MRI time series, ReHo also sensitive fluctuations cerebral blood flow (CBF) turn may influenced by cerebrovascular health. We accessed health with Framingham cardiovascular risk score (FCVRS). hypothesize signal regional CBF; and these associations can summarized as FCVRS→CBF→ReHo. used three independent...