A5069137051- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Nonlinear Dynamics and Pattern Formation
- Face Recognition and Perception
- Multisensory perception and integration
- stochastic dynamics and bifurcation
- Stress Responses and Cortisol
- Visual perception and processing mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Handwritten Text Recognition Techniques
- Bioinformatics and Genomic Networks
- Treatment of Major Depression
- Conservation, Biodiversity, and Resource Management
- Natural Language Processing Techniques
The University of Texas Health Science Center at Houston
2024-2025
University of Maryland, Baltimore
2016-2024
University of Arkansas for Medical Sciences
2022
Georgia State University
2010-2019
Radboud University Nijmegen
2019
The University of Melbourne
2019
Efforts to remediate the multiple cognitive function impairments in schizophrenia should consider white matter as one of underlying neural mechanisms.To determine whether altered structural brain connectivity is responsible for 2 core deficits schizophrenia- reduced information processing speed and impaired working memory.This cross-sectional study design took place outpatient clinics from August 1, 2004, 31, 2015. Participants included 166 patients with 213 healthy control individuals....
Abstract Despite the known benefits of data‐driven approaches, lack approaches for identifying functional neuroimaging patterns that capture both individual variations and inter‐subject correspondence limits clinical utility rsfMRI its application to single‐subject analyses. Here, using data from over 100k individuals across private public datasets, we identify replicable multi‐spatial‐scale canonical intrinsic connectivity network (ICN) templates via use multi‐model‐order independent...
Amplitude death is the cessation of oscillations that occurs in coupled nonlinear systems when fixed points are stabilized as a consequence interaction. We show here this phenomenon very general: it nonlinearly absence parameter mismatch or time delay although time-delayed interactions can enhance effect. Application made to synaptically model neurons, Rössler oscillators, well networks oscillators with coupling. By suitably designing coupling, arbitrary steady states be stabilized.
Signal transmission time delays in a network of nonlinear oscillators are known to be responsible for variety interesting dynamic behaviors including phase-flip transitions leading synchrony or out synchrony. Here, we uncover that general phenomena and can occur coupled bursting neurons with coupling types. The marked by changes both temporal phase-space characteristics the system. We demonstrate these phase-transitions Hindmarsh-Rose Leech-Heart interneuron models discuss implications...
Abstract Cognitive deficits contribute to functional disability in patients with schizophrenia and may be related altered networks that serve cognition. We evaluated the integrity of major assessed their role supporting two cognitive functions affected schizophrenia: processing speed (PS) working memory (WM). Resting‐state magnetic resonance imaging (rsfMRI) data, N = 261 327 controls, were aggregated from three independent cohorts using Enhancing NeuroImaging Genetics through Meta Analysis...
Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes resistance are unknown, but it associated earlier age at onset and more severe cognitive deficits. authors tested the hypothesis white matter deficits involved both neurodevelopment severity higher risk resistance.The study sample (N=122; mean age, 38.2 years) included initiation (N=45), whose were responsive (N=40), resistant...
Resting-state functional magnetic resonance imaging is currently the mainstay of neuroimaging and has allowed researchers to identify intrinsic connectivity networks (aka networks) at different spatial scales. However, little known about temporal profiles these whether it best model them as continuous phenomena in both space time or, rather, a set temporally discrete events. Both categories have been supported by series studies with promising findings. critical question focusing only on...
Both, pharmacological and genome-wide association studies suggest N-methyl-D-aspartate receptor (NMDAR) dysfunction excitatory/inhibitory (E/I)-imbalance as a major pathophysiological mechanism of schizophrenia. The identification shared fMRI brain signatures genetically pharmacologically induced NMDAR may help to define biomarkers for patient stratification. NMDAR-related genetic effects on functional connectivity were investigated by integrating three different datasets: (A) resting state...
Abstract We measured and compared heritability estimates for measures of functional brain connectivity extracted using the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) rsfMRI analysis pipeline in two cohorts: genetics structure (GOBS) cohort HCP (the Human Connectome Project) cohort. These cohorts were assessed conventional advanced (HCP) protocols, offering a test case harmonization phenotypes, to determine that show consistent in‐depth genome‐wide analysis. The GOBS...
Abstract Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer’s disease (AD). Both SZ and AD have white matter abnormalities cognitive deficits as core features. We hypothesized that aging in patients may be the development of cerebral deficit patterns similar to those observed AD. identified replicated aging-related increases similarity between The “regional vulnerability index” (RVI) was significantly higher compared healthy controls...
This review summarizes the last decade of work by ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance over 1,400 scientists across 43 countries, studying human brain in health and disease. Building on large-scale genetic studies that discovered first robustly replicated loci associated with metrics, has diversified into 50 working groups (WGs), pooling worldwide data expertise to answer fundamental questions neuroscience, psychiatry, neurology,...
Summary Objective In recent decades intracranial EEG (iEEG) recordings using increasing numbers of electrodes, higher sampling rates, and a variety visual quantitative analyses have indicated the presence widespread, high frequency ictal preictal oscillations (HFOs) associated with regions seizure onset. Seizure freedom has been correlated removal brain generating pathologic HFOs. However, analysis HFOs seldom applied to clinical problem planning surgical resection. We performed Granger...
Granger causality (GC) and dynamic causal modeling (DCM) are the two key approaches used to determine directed interactions among brain areas. Recent discussions have provided a constructive account of merits demerits. GC, on one side, considers dependencies measured responses, whereas DCM, other, models how neuronal activity in area causes dynamics another. In this study, our objective was establish construct validity between GC DCM context resting state functional magnetic resonance...
Abstract Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white integrity. We proposed the regional vulnerability index (RVI) to translate results Enhancing Neuro Imaging Genetics Meta‐Analysis studies individual level. calculated RVIs for cortical, subcortical, measurements a multimodality RVI. evaluated RVI as measure sensitive schizophrenia‐specific neuroanatomical symptoms studied timeline...
Schizophrenia spectrum disorder (SSD) is a chronic neuropsychiatric illness accompanied by significant brain structural and functional abnormalities higher rate of cardio- cerebrovascular comorbidities. We hypothesized that genetic environmental risk factors led to SSD act throughout the body demonstrated association between lower integrity peripheral vascular endothelium white matter (WM) microstructure. Microvascular endothelial function was evaluated using brachial artery post-occlusive...
Major depressive disorder (MDD) is a severe mental illness characterized more by functional rather than structural brain abnormalities. The pattern of regional homogeneity (ReHo) deficits in MDD may relate to underlying hypoperfusion. Capturing this deficit provides pattern-based biomarker for that linked the pathophysiology. To examine whether cortical ReHo patterns provide replicable sensitive reduced thickness and evaluate reflects cerebral blood flow (RCBF) vulnerability index (RVI) thus...
Accurate localization of the epileptic seizure onset zones (SOZs) is crucial for successful surgery, which usually depends on information obtained from intracranial electroencephalography (IEEG) recordings. The visual criteria and univariate methods analyzing IEEG recordings have not always produced clarity SOZs resection ultimate freedom patients. Here, to contribute improving understanding mechanism propagation over brain, we applied spectral interdependency time series recorded patients...
Our perception of the temporal order everyday external events depends on integrated sensory information in brain. understanding brain mechanism for temporal-order judgment (TOJ) unisensory events, particularly visual domain, is advanced. In case multisensory however, there are unanswered questions. Here, by using physically synchronous and asynchronous auditory–visual functional magnetic resonance imaging (fMRI) experiments, we identified network that associated with events. The activation...