A5101797292- Congenital heart defects research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Coronary Artery Anomalies
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Functional Brain Connectivity Studies
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Genomics, phytochemicals, and oxidative stress
- Microbial Natural Products and Biosynthesis
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Tracheal and airway disorders
- Molecular Biology Techniques and Applications
- Health, Environment, Cognitive Aging
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
Tianjin Chest Hospital
2015-2025
Tianjin University
2024-2025
Tianjin Medical University
2024
University of California, Los Angeles
2010-2021
Oslo University Hospital
2021
University of Oslo
2021
VA Greater Los Angeles Healthcare System
2021
Maastricht University
2021
University Health Network
2021
Toronto General Hospital
2021
Several theories have been proposed to conceptualize the pathological processes inherent schizophrenia. The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids prostaglandins lead diminished levels of prostaglandins, which in turn affect synaptic transmission. Here we sought determine lipidomic profiles associated with schizophrenia twin pairs discordant for as well unaffected pairs. study included serum samples from 19 (mean age 51...
This review summarizes the last decade of work by ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance over 1,400 scientists across 43 countries, studying human brain in health and disease. Building on large-scale genetic studies that discovered first robustly replicated loci associated with metrics, has diversified into 50 working groups (WGs), pooling worldwide data expertise to answer fundamental questions neuroscience, psychiatry, neurology,...
Macrophages play a dual role in the tumor microenvironment(TME), capable of secreting pro-inflammatory factors to combat tumors while also promoting growth through angiogenesis and immune suppression. This study aims explore characteristics macrophages lung adenocarcinoma (LUAD) establish prognostic model based on macrophage-related genes. We performed scRNA-seq analysis investigate macrophage heterogeneity their potential pseudotime evolutionary processes. Specifically, we used data...
The nuclear receptor REV-ERBα (nuclear subfamily 1, Group D member NR1D1) is one of the essential components circadian clock which modulates cell proliferation, glucose metabolism, inflammation, and many other biological processes. Modulation these processes are also relevant to cancer development. Previous studies have suggested that activation correlates with senescence death, but how play roles in tumor progression require further elucidation.We investigated expression clinical samples by...
Histone methyltransferases are crucial regulators in non-small cell lung cancer (NSCLC) development. This study explored the mechanism of histone methyltransferase SET domain containing 1A (SETD1A)-mediated H3K4me2 methylation NSCLC ferroptosis and provides novel targets for treatment.Upon downregulation SETD1A lines, proliferation potential, malondialdehyde (MDA), superoxide dismutase (SOD) glutathione (GSH) activities, iron content, SETD1A, long noncoding RNA HOXC cluster antisense 3...
Esophageal carcinoma is one of the most common malignancies in China. Previous studies reported that matrix metalloproteinases (MMPs) have important roles progression and invasion numerous types solid tumors. Among MMPs, MMP‑2 has been closely associated with tumor growth invasion. In present study, a short hairpin RNA (shRNA) lentiviral expression vector targeting gene was constructed order to observe inhibitory effect silencing on KYSE150 esophageal cell line vivo. Three small sequences...
<title>Abstract</title> <bold>Background:</bold> Lung adenocarcinoma (LUAD), as a major subtype of lung cancer, continues to have high incidence and mortality rates worldwide. Macrophages play complex role in the LUAD tumor microenvironment (TME), promoting growth metastasis while also participating resistance mechanisms. Given this, our study aims delve into heterogeneity macrophages within their impact on disease prognosis, further explore validate expression function macrophage marker...
Abstract Objective To develop a multimodal predictive model, Radiomics Integrated TLSs System (RAITS), based on preoperative CT radiomic features for the identification of in stage I lung adenocarcinoma patients and to evaluate its potential prognosis stratification guiding personalized treatment. Methods The most recent chest thin-slice scans postoperative hematoxylin eosin-stained pathology sections diagnosed with LUAD were retrospectively collected. Tumor segmentation was achieved using...
The Enhancing Neuroimaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development related cognitive, psychiatric behavioral manifestations. To that end, ENIGMA-CNV WG has collated CNV magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one largest studies date on effects CNVs...
Abstract BACKGROUND Human xenograft tumor models established by transplantation of human cell lines into immunodifficient mice have been routinely used for preclinical test anticancer agents. But a relatively low transplantability and resulted in limited number available selection right testing novel agents based on their antitumor mechanism. Recently, we developed large patient primary non-small lung cancer (NSCLC) transplanting patients’ fresh tissues nude mice, which employed METHODS The...
Objective To investigate the suppressive effect of miR-206 on malignant pleural mesothelioma (MPM) cell lines and mechanism. Methods A mimic was introduced into MPM H513, H2052 H2373 to overexpress this microRNA. (1) miRNA-induced changes in growth were evaluated by crystal violet staining. (2) Genes associated with cycle homeostasis apoptosis examined real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). (3) By gene knockdown experiment RT-qPCR, potential...