A5100423345- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Advanced Biosensing Techniques and Applications
- Lung Cancer Treatments and Mutations
- vaccines and immunoinformatics approaches
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Vitamin D Research Studies
Zhengzhou University
2016-2025
Southern Medical University
2024-2025
Peking University
2006-2025
Peking University People's Hospital
2017-2025
Zunyi Medical University
2024
Shaanxi University of Technology
2024
Southwest University
2021-2024
Chongqing Emergency Medical Center
2023-2024
Chongqing University
2023-2024
Gannan Medical University
2022-2023
Long non-coding RNAs (lncRNAs) are known to play important roles in different cell contexts, including cancers. However, little is about lncRNAs cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis, associated chronic inflammation and damage the biliary epithelium. The aim of study identify if any lncRNA might associate or oxidative stress CCA regulate disease progression. In this study, RNA-seqs datasets were used aberrantly expressed lncRNAs. Small interfering RNA...
Abstract Background Recent reports indicate that microRNAs (miRNAs) play a critical role in malignancies. However, the miRNAs pancreatic cancer remains to be determined. The purpose of this study was investigate aberrantly expressed tissues and demonstrate their roles disease progression. Results We detected expression patterns 10 adjacent benign by quantitative real time-PCR (qRT-PCR) found miR-15a miR-214 were dysregulated tumor samples. This is first time has been identified as cancer. In...
Long noncoding RNAs (lncRNAs) are aberrantly expressed in various cancers. Although lncRNA GAS5 (growth arrest-specific transcript 5) has been characterized as a tumor suppressor some kinds of cancer, its role and function hepatocellular carcinoma (HCC) remain unknown. The present report demonstrates that there lower levels GAS5, PDCD4, PTEN higher microRNA-21 (miR-21) HCC tissues than adjacent normal tissues. Moreover, the miR-21 were correlated with clinicopathological characteristics HCC....
// Wenzhi Guo 1 , Jiakai Zhang Dongyu 2 Shengli Cao Gongquan Li Shuijun Zhihui Wang Peihao Wen Han Yang Xiaoyi Shi Jie Pan and Hua Ye 3 Department of Hepatic Biliary Pancreatic Surgery, Henan Key Laboratory Digestive Organ Transplantation, The First Affiliated Hospital Zhengzhou University, Zhengzhou, Henan, P.R. China Infectious Disease, College Public Health, Correspondence to: Guo, email: guoweizhi@aliyun.com Ye, yehuazz@aliyun.com Keywords: circ-ITCH, hepatocellular carcinoma,...
Abstract Circulating tumor DNA (ctDNA) isolated from peripheral blood has recently been shown to be an alternative source detect gene mutations in primary tumors; however, most previous studies have focused on advanced stage cancers and few evaluated ctDNA detection early-stage lung cancer. In the present study, samples were collected prospectively 58 non-small cancer (NSCLC) patients (stages IA, IB IIA) a targeted sequencing approach was used somatic driver matched (tDNA) plasma ctDNA. We...
Abstract Circulating tumor DNA (ctDNA) in peripheral blood is a “liquid biopsy” that contains representative information including gene mutations. Additionally, repeated ctDNA samples can be easily obtained to monitor response treatment and disease progression, which may especially valuable lung cancer patients with tumors cannot biopsied or removed. To investigate the changes after surgical resection, before surgery were collected prospectively from 41 non-small (NSCLC) patients. Somatic...
Purpose: To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between neuronal damage. Methods: This is prospective, observational study including 49 eyes from 38 PD their early stages 34 28 healthy controls comparable age range. Macula microvasculature was evaluated spectral-domain (SD-OCT) intraretinal layer thickness SD-OCT. A custom algorithm used for segmentation of...
Abstract N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and the therapeutic functions antibody-based drugs; however, low-abundance species are difficult to detect. Here we show a glycomic approach detect these human IgGs using specialized microfluidic chip. We discover 20 sulfated 4 acetylated N-glycans IgGs. Using multiple reaction monitoring method, precisely quantify previously undetected low-abundance, trace even ultra-trace N-glycans. From...
Current diagnosis and treatment of rheumatoid arthritis (RA) is still challenging. More than one-third patients with RA could not be accurately diagnosed because lacking biomarkers. Our recent study reported that scavenger receptor-A (SR-A) a biomarker for RA, especially anticyclic citrullinated peptide antibody (anti-CCP)–negative RA. Here, we further identified the B cell autoantigenic epitopes SR-A. By large-scale multicenter including one training three validation cohorts 1954...
Camptothecin (CPT) is an effective chemotherapeutic agent for treatment of patients with cancer. The mechanisms underlying CPT-mediated responses in cancer cells are not fully understood. MicroRNA (miRNA) play important roles tumorigenesis and drug sensitivity. However, the interaction between camptothecin miRNA has been previously explored. In this study, we verified that miR-125b was down-regulated CPT-induced apoptosis ectopic expression partially restored cell viability inhibited induced...
The optimization of the pharmacokinetic performance various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors following oral administration to either beagle dogs or CM-monkeys is described. molecules described in this work are composed a peptidomimetic binding determinant and an alpha,beta-unsaturated ester Michael acceptor moiety which forms irreversible covalent adduct with active site cysteine residue enzyme. Modification contained within these compounds detailed...
Pancreatic cancer (PC) is a highly lethal human cancer. We previously found that Serine protease 3 (PRSS3), as an oncogene, significantly upregulated in PC. In this study, we aimed to investigate the potential mechanism of PRSS3 dysregulation research, low miR-217 and high circ-ADAM9 expression were PC tissues cell lines, which was closely associated with advanced clinical stage lymph node metastasis. Patients or had shorter survival time than those expression. Functionally, manipulation...
Hepatocellular carcinoma (HCC) is one of the most fatal cancers worldwide. In this article, we show that expression abnormal spindle‐like microcephaly‐associated protein (ASPM) up‐regulated in liver cancer samples, and up‐regulation significantly associated with tumor aggressiveness reduced survival times patients. Down‐regulation ASPM inhibits proliferation, invasion, migration epithelial‐to‐mesenchymal transition HCC cells vitro formation nude mice. interacts disheveled‐2 (Dvl2)...
Breast cancer is the most common malignancy and leading cause of deaths in women worldwide. While specific genetic mutations have been linked to 5–10% breast cases, other environmental epigenetic factors influence development progression cancer. Since unique patterns observed individual samples, identification characterization distinctive molecular profile needed develop more effective target therapies. Until recently, identifying via personalized DNA sequencing was impractical expensive....
Lung cancer is the most common malignancy and leading cause of deaths worldwide. While smoking by far lung cancer, other environmental genetic factors influence development progression cancer. Since unique mutations patterns have been observed in individual samples, identification characterization distinctive molecular profile essential for developing more effective, tailored therapies. Until recently, personalized DNA sequencing to identify was impractical expensive. The recent...
Abstract The aim of this study was to develop a noninvasive serological diagnostic approach in identifying and evaluating panel candidate autoantibodies tumor‐associated antigens (TAAs) based on protein microarray technology for early detection ovarian cancer (OC). Protein 154 proteins encoded by 138 driver genes used screen anti‐TAA discovery cohort containing 17 OC 27 normal controls (NC). Indirect enzyme‐linked immunosorbent assay (ELISA) detect the content sera from 140 subjects training...