A5101547797- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Signaling Pathways in Disease
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- Connective Tissue Growth Factor Research
- Galectins and Cancer Biology
- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- RNA modifications and cancer
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Oral and Maxillofacial Pathology
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Inflammasome and immune disorders
- Fibroblast Growth Factor Research
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
Sun Yat-sen Memorial Hospital
2012-2024
Sun Yat-sen University
2012-2024
Weifang People's Hospital
2022
Guangzhou Medical University
2022
China University of Mining and Technology
2008-2020
Institute of Microbiology
2015
The First Affiliated Hospital, Sun Yat-sen University
2014
The human genome encodes many long non-coding RNAs (lncRNAs). However, their biological functions, molecular mechanisms, and the prognostic value associated with pancreatic ductal adenocarcinoma (PDAC) remain to be elucidated. Here, we identify a fundamental role for lncRNA HOXA transcript at distal tip (HOTTIP) in progression chemoresistance of PDAC.High-throughput microarrays were performed detect expression profiles lncRNAs messenger eight PDAC tissues four tissues. Quantitative real-time...
Abstract Chemoresistance is a major cause of cancer progression and the mortality patients. Developing safe strategy for enhancing chemosensitivity challenge biomedical science. Recent studies have suggested that vitamin D supplementation may decrease risk many cancers. However, role in chemotherapy remains unknown. We found sensitised oral cells to cisplatin partially reversed resistance. Using RNA-seq, we discovered lipocalin 2 (LCN2) an important mediator. Cisplatin enhanced expression...
Background: Surgery and postoperative adjuvant therapy is the standard treatment for locally advanced resectable oral squamous cell carcinoma (OSCC), while neoadjuvant chemoimmunotherapy (NACI) believed to lead better outcomes. This study aims investigate effectiveness of NACI regimens in treating OSCC. Materials methods: Patients diagnosed with OSCC who received non-NACI were reviewed between December 2020 June 2022 our single center. The pathologic response was evaluated efficacy...
The aim of the present study was to investigate expression and function metastasis-associated in colon cancer 1 (MACC1) tongue squamous cell carcinoma (TSCC) its relationship with extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147). Levels MACC1 EMMPRIN were analyzed 65 paraffin‑embedded tissue specimens TSCC adjacent non-cancerous tissues using immunohistochemistry (IHC). highly associated lymphatic metastasis expression. Overexpression significantly correlated poor overall...
Resistance to cisplatin-based chemotherapy is responsible for the majority of deaths from head and neck squamous cell carcinoma (HNSCC). In this study, using genome-wide gene expression analysis investigate potential molecular mediators HNSCC chemoresistance, we identified SERPINB2, a known inhibitor extracellular serine proteinase urokinase-type plasminogen activator (uPA), as an important candidate. Whereas SERPINB2 function suppressor uPA cascades, many which play roles in tumor invasion...
Head and neck cancer is the sixth most common in world of them are squamous cell carcinomas. High frequency cisplatin resistance head carcinoma ( HNSCC ) leads to tumor relapse irresponsiveness cisplatin‐based chemotherapy. However, mechanisms underlying still largely unrevealed. In this study, we found that CD 147 was overexpressed cisplatin‐resistant lines. Based on result, expression down‐regulated line observed sensitivity increased, as showed results MTT assay PI ‐staining apoptotic...
GSDMD is the key effector of pyroptosis, but its non-pyroptosis-related functions have seldom been reported. Here, we report that overexpressed in different types tumours, including head and neck squamous-cell carcinoma, it promotes sensitivity tumour cells to cisplatin. Unexpectedly, enhanced cisplatin mediated by apoptosis not well-known function GSDMD. Furthermore, found can activate unfolded protein response promoting phosphorylation eIF2α. Mechanistically, demonstrated directly bind...
Background: Extracellular matrix metalloproteinase inducer (EMMPRIN) is identified as a tumor‐cell membrane protein that stimulates metalloproteinases (MMPs) production. Several studies have shown higher EMMPRIN expression associated with shorter survival time and correlated significantly more advanced clinico‐parameters of cancer. The aim this study was to investigate the relationship between clinico‐pathologic characteristics EMMPRIN, prognostic significance in human tongue squamous cell...
Insulinlike growth factor II mRNA-binding protein 3 (IMP3) is a newly identified that involved in embryogenesis and carcinogenesis of some malignant tumors. The aim this study was to investigate the clinicopathologic significance tongue squamous cell carcinoma (SCC). expression IMP3 65 samples SCC 27 cases oral leukoplakia (OL) evaluated by immunohistochemistry. These levels were correlated with clinical pathologic features as well death from SCC. Weak immunohistochemical stain for all 19 OL...
The neurofilament light polypeptide ( NEFL ) gene located on chromosome 8q21 is associated with the cancer of several organs and regarded as a potential tumor suppressor gene. However, role protein has not yet been studied in cells. Although evidence suggests that there correlation between expression cancer, studies regarding have mostly limited to neurological diseases, such Charcot–Marie–Tooth's disease CMT ). Most these explored cell apoptosis and/or invasion. In this study, was...
Extracellular matrix metalloproteinase inducer (EMMPRIN), a plasma membrane protein of the immunoglobulin (Ig) superfamily, has been reported to promote cancer cell invasion and metastasis in several human malignancies. However, roles different EMMPRIN isoforms their associated mechanisms head neck progression remain unknown. Using quantitative real-time PCR, we found that isoform 2 (EMMPRIN-2) was only overexpressed both tissues lines it with metastasis. To determine effects EMMPRIN-2 on...
It has been well established that the aberrant activation of Wnt/β-catenin signal correlates to endometrial endometrioid adenocarcinoma (EEC). As an effector mediated antiapoptotic signal, role Wnt-induced secreted protein-1 (WISP-1) in EEC still remains unclear.We used immunohistochemistry and quantitative real-time RT-PCR examine expression WISP-1, estrogen receptor (ER) progesterone (PR) 86 cases EEC, with 20 hyperplasia, proliferative endometrium secretory as control group. We also...
To investigate the expression of CD44v3 and vascular endothelial growth factor C (VEGF-C) in gastric adenocarcinoma correlation with erythropoietin (EPO) clinicopathological features.The CD44v3, VEGF-C EPO was evaluated by immunohistochemical staining 169 adenocarcinomas. The correlations between these parameters patients' features were analyzed statistically.CD44v3 positive 50 (29.6%) 82 (48.5%) patients, respectively. High associated poor cellular differentiation, extensive lymph node...