A5080158470- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Reconstructive Facial Surgery Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Topic Modeling
- Composite Structure Analysis and Optimization
- Cancer Research and Treatments
- Inflammasome and immune disorders
- Vibrio bacteria research studies
- Ear and Head Tumors
- Bacteriophages and microbial interactions
- Enterobacteriaceae and Cronobacter Research
- Numerical methods in engineering
- Cancer, Lipids, and Metabolism
- Advanced Text Analysis Techniques
- Mechanical Behavior of Composites
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
South China Sea Institute Of Oceanology
2023-2024
Institute of Oceanology
2023-2024
Chinese Academy of Sciences
2023-2024
University of Chinese Academy of Sciences
2023-2024
Cornell University
2022-2024
Jiangxi University of Science and Technology
2024
Stomatology Hospital
2013-2023
New York State College of Agriculture & Life Sciences
2022-2023
Abstract Chemoresistance is a major cause of cancer progression and the mortality patients. Developing safe strategy for enhancing chemosensitivity challenge biomedical science. Recent studies have suggested that vitamin D supplementation may decrease risk many cancers. However, role in chemotherapy remains unknown. We found sensitised oral cells to cisplatin partially reversed resistance. Using RNA-seq, we discovered lipocalin 2 (LCN2) an important mediator. Cisplatin enhanced expression...
The mobile colistin resistance gene mcr-3 is globally disseminated in both Enterobacteriaceae and Aeromonas species, with the latter potentially serving as a reservoir for this gene. Here, we investigated prevalence of rectal swabs from humans, food-producing animals their products, aquatic environment, genetic relationships between -positive isolates.
A correction to this paper has been published and can be accessed via a link at the top of paper.
The aim of this study was to investigate the prevalence polymyxin resistance gene mcr-1 in Enterobacteriaceae from environmental water sources Hangzhou, China. Colistin-resistant bacteria were isolated samples using an enrichment broth culture method, screened for mcr-1, and then analyzed location transferability Isolates positive further examined determine their susceptibility profiles presence additional genes. Twenty-three mcr-1-positive isolates (16 Escherichia coli, two Citrobacter...
Genetically encoded photoswitches have enabled spatial and temporal control of cellular events to achieve tailored functions in living cells, but their applications probe the structure-function relations signaling proteins are still underexplored. We illustrate herein incorporation various blue light-responsive photoreceptors into modular domains stromal interaction molecule 1 (STIM1) manipulate protein activity faithfully recapitulate STIM1-mediated events. Capitalizing on these optogenetic...
Abstract Background EGFR is an important signal involved in tumor growth that can induce metastasis and drug resistance. Exploring targets for effective regulation topic current research development. Inhibiting effectively inhibit the progression lymph node of oral squamous cell carcinoma (OSCC) because OSCC a type cancer with high expression. However, problem resistance particularly prominent, identifying new target could reveal strategy. Methods We sequenced wild or EGFR-resistant cells...
Abstract The filamentous ‘Pf’ bacteriophages of Pseudomonas aeruginosa play roles in biofilm formation and virulence, but mechanisms governing Pf prophage activation biofilms are unclear. Here, we identify a regulatory module, KKP (kinase-kinase-phosphatase), that controls virion production co-resident prophages mediates host defense against diverse lytic phages. consists Ser/Thr kinases PfkA PfkB, phosphatase PfpC. have multiple targets, one which is MvaU, nucleoid-binding protein known...
Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP allow reconstruction the key molecular steps involved these two non-apoptotic cell death pathways by harnessing power light. Further, use LiPOPs coupled upconversion nanoparticles or bioluminescence demonstrated to achieve wireless chemo-optogenetic killing cancer multiple mouse tumor models. can trigger necroptotic...
Abstract In the context of cancer therapy, a recently identified therapeutic target is represented by essential subtype RNA transcripts ‐ long noncoding RNAs (lncRNA). While this case, it especially difficult to successfully regulate expression in vivo, particularly due protection granted nuclear envelope lncRNAs. This study documents development nucleus‐specific interference (RNAi) nanoparticle (NP) platform for targeted regulation lncRNA function, order effectuate successful therapy. An...
Abstract Objective To analyze the abundance of infiltrating tumor immune cells in patients with oral squamous cell carcinoma (OSCC) and to search for potential targets that can predict patient prognosis. Methods A total 400 samples from 210 OSCC were collected using The Cancer Genome Atlas (TCGA) database. CIBERSORTx was used evaluate infiltration cells. Potential target genes searched prognosis through case grouping, differential analysis, enrichment analysis. Surgical excisional tissue...
Abstract Extracellular vesicles (EVs) are emerging as promising carriers for the delivery of therapeutic biologics. Genetic engineering represents a robust strategy loading proteins interest into EVs. Identification EV‐enriched facilitates protein cargo efficiency. Many sorted EVs via an endosomal sorting complex required transport (ESCRT)‐dependent pathway. In parallel, viruses hijack this EV biosynthesis machinery conserved late domain motifs to promote egress from host cells. Inspired by...
1,25-Dihydroxyvitamin D3 (1,25D3) is the active form of vitamin D with antineoplastic effects. The glutathione peroxidase-1 (GPX1) gene associated tumour progression. present study aimed to explore role GPX1 in 1,25D3-mediated progression salivary adenoid cystic carcinoma (SACC). Downregulating expression inhibited SACC cell proliferation, chemoresistance, motility, and uPA secretion, but promoted apoptosis via NF-κB pathway. Pre-processing 1,25D3 NF-κB/GPX1/uPA, which subsequently...