A5031987801- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Metabolism, Diabetes, and Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- Calpain Protease Function and Regulation
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Cancer therapeutics and mechanisms
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Chongqing Medical University
2008-2025
Sino Biological (China)
2025
Guangzhou University of Chinese Medicine
2025
Nanjing Medical University
2025
Shenyang Pharmaceutical University
2025
Children's Hospital of Chongqing Medical University
2023-2025
Guangdong Medical College
2024
Capital Medical University
2024
Ferroptosis is a reactive oxygen species (ROS)- and iron-dependent form of regulated cell death (RCD), playing critical roles in organ injury targeting therapy cancers. Previous studies have demonstrated that ferroptosis participates the development cardiomyopathy including cardiac hypertrophy, diabetic doxorubicin-induced cardiotoxicity. However, role sepsis-induced remains unclear. This study aimed to explore underlying mechanism on lipopolysaccharide (LPS)-induced injury. Mice were...
Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis are involved in the development of sepsis sepsis-induced cardiomyopathy (SIC). Stimulator interferon genes (STING) is an indispensable molecule could regulate inflammation immune response multiple diseases. However, role STING cardiovascular disease, especially SIC remains unclear. This study was designed to investigate potential molecular mechanisms lipopolysaccharide (LPS)-induced cardiac injury using...
The use of tyrosine kinase inhibitors (TKI) with activity against ALK, ROS1, or TRKA-C can result in significant clinical benefit patients diverse tumors harboring NTRK1-3 rearrangements; however, resistance invariably develops. emergence on-target domain mutations represents a major mechanism acquired resistance. Solvent-front substitutions such as ALKG1202R, ROS1G2032R ROS1D2033N, TRKAG595R, and TRKCG623R are among the most recalcitrant these mechanisms. Repotrectinib (TPX-0005) is...
OBJECTIVE Traditional blood glucose–lowering agents do not sustain adequate glycemic control in most type 2 diabetic patients. Preclinical studies with exenatide have suggested sustained improvements β-cell function. We investigated the effects of 52 weeks treatment or insulin glargine followed by an off-drug period on hyperglycemic clamp–derived measures function, control, and body weight. RESEARCH DESIGN AND METHODS Sixty-nine metformin-treated patients diabetes were randomly assigned to...
Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing 5 (FNDC5) its cleaved form, irisin, could preserve mitochondrial function attenuate oxidative damage as well cell apoptosis, however, role DOX-induced cardiotoxicity remains unknown. Our present study aimed to investigate the underlying mechanism of FNDC5 on Cardiomyocyte-specific overexpression was achieved using...
Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant anti-apoptotic capacities. Our present study aimed to investigate effect matrine on DOX-induced cardiotoxicity try unearth underlying mechanisms. Mice were exposed with DOX generate or normal saline as control. H9C2 cells used verify vitro. injection triggered increased generation reactive oxygen species (ROS) excessive...
BACKGROUND: The majority of people with diabetes are susceptible to cardiac dysfunction and heart failure, conventional drug therapy cannot correct diabetic cardiomyopathy progression. Herein, we assessed the potential role therapeutic value USP28 (ubiquitin-specific protease 28) on metabolic vulnerability cardiomyopathy. METHODS: type 2 mouse model was established using db/db leptin receptor–deficient mice high-fat diet/streptozotocin–induced mice. Cardiac-specific knockout in background...
Obesity and related metabolic diseases associated with chronic low-grade inflammation greatly compromise human health. Previous observations on the roles of interferon regulatory factors (IRFs) in regulation metabolism prompted investigation involvement a key family member, IRF3, disorders. IRF3 expression liver is decreased animals diet-induced genetic obesity. The global knockout (KO) significantly promotes high-fat diet (HFD)-induced hepatic insulin resistance steatosis; contrast,...
Agonists of peroxisome proliferator-activated receptor gamma (PPAR-γ) can activate 5' AMP-activated protein kinase alpha (AMPKα) and exert cardioprotective effects. A previous study has demonstrated that rosmarinic acid (RA) PPAR-γ, but its effect on cardiac remodeling remains largely unknown. Our aimed to investigate the RA clarify underlying mechanism. Mice were subjected aortic banding generate pressure overload induced then orally administered (100 mg/kg/day) for 7 weeks beginning 1 week...
Cardiomyocyte apoptosis is a key event in the process of doxorubicin (DOX)-induced cardiotoxicity.Our previous study found that rosmarinic acid (RA) could attenuate pressure overload-induced cardiac dysfunction via fibroblasts (CFs), however its effect DOX-induced cardiotoxicity remains unknown.In present study, mice were subjected to single intraperitoneal injection DOX (15mg/kg) generate cardiotoxicity.Histological examination, echocardiography, and molecular markers used evaluate effects...
Andrographolide (Andr) is a major component isolated from the plant Andrographis paniculata. Inflammation, apoptosis, and impaired angiogenesis are implicated in pathogenesis of high glucose (HG)-induced injury vascular endotheliocytes. Our study aimed at evaluating effect Andr on HG-induced HUVEC underlying mechanism. HUVECs were exposed to HG levels (33 mM) treated with (0, 12.5, 25, 50 μM). Western blot analysis, real-time PCR, immunofluorescence staining, scratch test, tube formation...
Adverse cardiac remodeling after myocardial infarction (MI) is associated with extremely high mortality rates worldwide. Although optimized medical therapy, Preservation of lusitropic and inotropic function protection against adverse in ventricular structure remain relatively frequent. This study demonstrated that Andrographolide (Andr) significantly ameliorated induced by improves contractile mice LAD ligation compared the control group. Briefly, Andr markedly attenuated fibrosis relieved...
Abstract Since 2011, with the approval of crizotinib and subsequent four additional targeted therapies, anaplastic lymphoma kinase (ALK) inhibitors have become important treatments for a subset patients lung cancer. Each generation ALK inhibitor showed improvements in terms central nervous system (CNS) penetration potency against wild-type (WT) ALK, yet key continued limitation is their susceptibility to resistance from active-site mutations. The solvent front mutation (G1202R) gatekeeper...
Cathepsin B (CTSB), a member of the lysosomal cathepsin family that is expressed in both murine and human hearts, was previously shown to participate apoptosis, autophagy, progression certain types cancers. Recently, CTSB has been linked myocardial infarction. Given L, another family, ameliorates pathological cardiac hypertrophy, we hypothesized plays role pressure overload-induced remodeling. Here report upregulated cardiomyocytes response hypertrophic stimuli vivo vitro. Moreover, knockout...
Obesity is a calorie-excessive state associated with high risk of diabetes, atherosclerosis, and certain types tumors. may induce inflammation insulin resistance (IR). We found that the expression interferon (IFN) regulatory factor 9 (IRF9), major transcription mediating IFN responses, was lower in livers obese mice than those their lean counterparts. Furthermore, whole-body IRF9 knockout (KO) were more had aggravated IR, hepatic steatosis, after chronic high-fat diet feeding. In contrast,...
Diabetic cardiomyopathy (DCM) is associated with a greater risk of mortality in patients diabetes mellitus. Currently, no specific treatment has been suggested for DCM treatment. This study demonstrated that myricetin (M) attenuated DCM‐associated cardiac injury mice subjected to streptozotocin (SZT) and neonatal rat cardiomyocytes (NRCM) challenged high glucose. In vivo investigation 6 months M (200 mg/kg/d) significantly alleviated hypertrophy, apoptosis, interstitial fibrosis....